Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amanda M Travis"'
Autor:
Amanda M Travis, Samiya Manocha, Jason R Willer, Timothy S Wessler, Nikolai P Skiba, Jillian N Pearring
Publikováno v:
eLife, Vol 12 (2023)
The small GTPase Arl3 is important for the enrichment of lipidated proteins to primary cilia, including the outer segment of photoreceptors. Human mutations in the small GTPase Arl3 cause both autosomal recessive and dominant inherited retinal dystro
Externí odkaz:
https://doaj.org/article/ecaf601b5a6b45ae80fe434e2c14158f
Autor:
Ekaterina S. Lobanova, Stella Finkelstein, Jing Li, Amanda M. Travis, Ying Hao, Mikael Klingeborn, Nikolai P. Skiba, Raymond J. Deshaies, Vadim Y. Arshavsky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Proteasomal overload can be found in a broad spectrum of mouse models of retinal degeneration. Here the authors find that overexpressing the PA28α subunit of the 11S proteasome cap increased the number of surviving functional photoreceptor cells in
Externí odkaz:
https://doaj.org/article/f205dd40283c431b8415d04bab375e77
Autor:
Amanda M. Travis, Samiya Manocha, Jason R. Willer, Timothy S. Wessler, Nikolai P. Skiba, Jillian N. Pearring
Publikováno v:
eLife. 12
The small GTPase Arl3 is important for the enrichment of lipidated proteins to primary cilia, including the outer segment of photoreceptors. Human mutations in the small GTPase Arl3 cause both autosomal recessive and dominant inherited retinal dystro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22b0a23484521b5456b21c0238e178f1
https://pubmed.ncbi.nlm.nih.gov/36598133
https://pubmed.ncbi.nlm.nih.gov/36598133
Autor:
Mikael Klingeborn, Amanda M. Travis, Vadim Y. Arshavsky, Alexander V. Kolesnikov, Luyu Wang, Sidney M. Gospe, Vladimir J. Kefalov
Publikováno v:
J Biol Chem
Mitochondrial dysfunction is an important cause of heritable vision loss. Mutations affecting mitochondrial bioenergetics may lead to isolated vision loss or life-threatening systemic disease, depending on a mutation's severity. Primary optic nerve a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2d4edac6952e354d175c59fd2c7d59f
https://doi.org/10.1074/jbc.ra119.007945
https://doi.org/10.1074/jbc.ra119.007945
Autor:
Luyu Wang, Sidney M. Gospe, Vadim Y. Arshavsky, Mikael Klingeborn, Amanda M. Travis, Ying Hao
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Optic atrophy resulting from retinal ganglion cell (RGC) degeneration is a prominent ocular manifestation of mitochondrial dysfunction. Although transgenic mice lacking the mitochondrial complex I accessory subunit NDUFS4 develop early-onset optic at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c136a2200d0a98c2c6976b1a59576fe
https://doi.org/10.1038/s41598-020-73353-0
https://doi.org/10.1038/s41598-020-73353-0
Autor:
Vadim Y. Arshavsky, Arlene A. Hirano, Stephanie J. Heflin, Nicholas C. Brecha, Amanda M. Travis
Publikováno v:
The Journal of Neuroscience. 38:723-732
The vertebrate retina has the remarkable ability to support visual function under conditions of limited illumination, including the processing of signals evoked by single photons. Dim-light vision is regulated by several adaptive mechanisms. The mech
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e04f0849924fcf19db025fe8d8a79557
https://doi.org/10.1523/jneurosci.1994-17.2017
https://doi.org/10.1523/jneurosci.1994-17.2017
Autor:
Keunyoung Kim, Ying Hao, Rose Mathew, Jindong Ding, Andrea Thor, Daniel R. Saban, Jillian N. Pearring, Joseph C. Besharse, Marie E. Burns, Woo-Kuen Lo, Chen Yu, Joan Kalnitsky, Tylor R. Lewis, Sondip K. Biswas, William J. Spencer, Sebastien Phan, Amanda M. Travis, Vadim Y. Arshavsky, Mark H. Ellisman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 116, iss 26
Progressive rod-cone degeneration (PRCD) is a small protein residing in the light-sensitive disc membranes of the photoreceptor outer segment. Until now, the function of PRCD has remained enigmatic despite multiple demonstrations that its mutations c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e76d985fe8670b0318ffab7b90e8746
https://pubmed.ncbi.nlm.nih.gov/31189593
https://pubmed.ncbi.nlm.nih.gov/31189593
Autor:
Ying Hao, Stella Finkelstein, Ekaterina S. Lobanova, Nikolai P. Skiba, Mikael Klingeborn, Amanda M. Travis, Jing Li, Raymond J. Deshaies, Vadim Y. Arshavsky
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Nature Communications
Nature Communications
Inherited retinal degenerations, affecting more than 2 million people worldwide, are caused by mutations in over 200 genes. This suggests that the most efficient therapeutic strategies would be mutation independent, i.e., targeting common pathologica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e696193168c35362191efb4c72740c3
https://doi.org/10.1038/s41467-018-04117-8
https://doi.org/10.1038/s41467-018-04117-8
Publikováno v:
Nature structural & molecular biology
The diverse RGS protein family is responsible for the precise timing of G-protein signaling. To understand how RGS protein structure encodes their common ability to inactivate G-proteins and their selective G-protein recognition, we integrated struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0c2f7ac6cd20a7ca12b065efed5ab1c
https://doi.org/10.1038/nsmb.2068
https://doi.org/10.1038/nsmb.2068