Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Amanda Luu"'
Autor:
Rajappa S. Kenchappa, Panagiotis Mistriotis, Emily Wisniewski, Santanu Bhattacharya, Tanmay Kulkarni, Rita West, Amanda Luu, Meghan Conlon, Ernest Heimsath, James F. Crish, Hannah S. Picariello, Athanassios Dovas, Natanael Zarco, Montserrat Lara-Velazquez, Alfredo Quiñones-Hinojosa, John A. Hammer, Debrabrata Mukhopadhyay, Richard E. Cheney, Konstantinos Konstantopoulos, Peter Canoll, Steven S. Rosenfeld
Publikováno v:
iScience, Vol 23, Iss 12, Pp 101802- (2020)
Summary: Invasion and proliferation are defining phenotypes of cancer, and in glioblastoma blocking one stimulates the other, implying that effective therapy must inhibit both, ideally through a single target that is also dispensable for normal tissu
Externí odkaz:
https://doaj.org/article/f2e6aa1145ad433d8b3c718e8b0b6bf0
Autor:
Rita West, Karen E. Parrish, William F. Elmquist, Alfredo Quinones Hinojosa, Jann N. Sarkaria, Steven S. Rosenfeld, Gautham Gampa, James F. Crish, Rajappa S. Kenchappa, Afroz S. Mohammad, Amanda Luu, Minjee Kim
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
Scientific Reports
Scientific Reports
Glioblastoma, the most lethal primary brain cancer, is extremely proliferative and invasive. Tumor cells at tumor/brain-interface often exist behind a functionally intact blood-brain barrier (BBB), and so are shielded from exposure to therapeutic dru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd6a43e2c17460eebb1980045d988941
http://link.springer.com/article/10.1038/s41598-020-63494-7
http://link.springer.com/article/10.1038/s41598-020-63494-7
Autor:
Amanda Luu, David J. Odde, Vandana Rai, Rita West, Katarzyna Pogoda, Rajappa S. Kenchappa, Athanassios Dovas, Steven S. Rosenfeld, Paul A. Janmey, Thomas T. Egelhoff, Peter Canoll, Unnikrishnan M. Chandrasekharan, James F. Crish, Jan Lammerding, Hannah S. Picariello, Emily Bell, Mariah McMahon
Publikováno v:
Proceedings of the National Academy of Sciences. 116:15550-15559
The ability of glioblastoma to disperse through the brain contributes to its lethality, and blocking this behavior has been an appealing therapeutic approach. Although a number of proinvasive signaling pathways are active in glioblastoma, many are re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c35f9d710596cc5a599663008b36c53
https://doi.org/10.1073/pnas.1902847116
https://doi.org/10.1073/pnas.1902847116
Autor:
Rajappa S, Kenchappa, Yi, Liu, Michael G, Argenziano, Matei A, Banu, Ann C, Mladek, Rita, West, Amanda, Luu, Alfredo, Quiñones-Hinojosa, Dolores, Hambardzumyan, Verline, Justilien, Michael, Leitges, Jann N, Sarkaria, Peter A, Sims, Peter, Canoll, Nicole R, Murray, Alan P, Fields, Steven S, Rosenfeld
Publikováno v:
Cell reports. 37(8)
We report that atypical protein kinase Cι (PKCι) is an oncogenic driver of glioblastoma (GBM). Deletion or inhibition of PKCι significantly impairs tumor growth and prolongs survival in murine GBM models. GBM cells expressing elevated PKCι signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a8f2f5ade78b1b9106e9ac5310a1a6aa
https://pubmed.ncbi.nlm.nih.gov/34818553
https://pubmed.ncbi.nlm.nih.gov/34818553
Autor:
Rita West, Amanda Luu, Michael G. Argenziano, Matei A. Banu, Verline Justilien, Peter A. Sims, Alfredo Quinones-Hinojosa, Ann C. Mladek, Dolores Hambardzumyan, Yi Liu, Nicole R. Murray, Alan P. Fields, Steven S. Rosenfeld, Michael Leitges, Rajappa S. Kenchappa, Jann N. Sarkaria, Peter Canoll
Publikováno v:
Cell Reports. 37:110054
Summary We report that atypical protein kinase Cι (PKCι) is an oncogenic driver of glioblastoma (GBM). Deletion or inhibition of PKCι significantly impairs tumor growth and prolongs survival in murine GBM models. GBM cells expressing elevated PKC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::93848b683e586e459808964638ce4fd3
https://doi.org/10.1016/j.celrep.2021.110054
https://doi.org/10.1016/j.celrep.2021.110054
Autor:
Amanda Luu, Ivanka Matsuba
Named a Best Interior Design Book of 2020 by Food52'A modern take on a centuries-old art that's breathtakingly simple.”—Booklist, starred review At its heart, the Japanese art of ikebana is about celebrating an intimate connection with nature. To
Comparison of two commercial enzyme-linked immunosorbent assays for detection of complement factor D
Autor:
Dharaben Patel, Amanda Luu, Manuel Galvan, Guangwei Yang, Yongsen Zhao, Jane A. Thanassi, Mingjun Huang, Wengang Yang, Steven D. Podos
Publikováno v:
Molecular Immunology. 102:199-200
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de0571ef57b5affd3ee3bf6f6dd68900
https://doi.org/10.1016/j.molimm.2018.06.181
https://doi.org/10.1016/j.molimm.2018.06.181
Autor:
Jane A. Thanassi, Dharaben Patel, Guangwei Yang, Steven D. Podos, Manuel Galvan, Yongsen Zhao, Mingjun Huang, Wengang Yang, Amanda Luu
Publikováno v:
Molecular Immunology. 102:219-220
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48ce313fda4e231b49daada2b06b3204
https://doi.org/10.1016/j.molimm.2018.06.226
https://doi.org/10.1016/j.molimm.2018.06.226
Autor:
Yi Liu, Ann C. Mladek, Alan P. Fields, Rita West, Nicole R. Murray, Rajappa S. Kenchappa, Amanda Luu, Steven S. Rosenfeld, Jann N. Sarkaria
Publikováno v:
Neuro Oncol
In glioblastoma (GBM), invasion and proliferation are reciprocally related—e.g., targeting one stimulates the other. Thus, effective therapy for GBM requires finding targets that drive both invasion and proliferation and which are druggable, ideall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17183d8b17a143f80de26929f423f25d
https://doi.org/10.1093/neuonc/noz175.1189
https://doi.org/10.1093/neuonc/noz175.1189
Autor:
Jason Allan Wiles, Wengang Yang, John Lahey, Dharaben Patel, Joanne Fabrycki, Xuan Yuan, Jane A. Thanassi, Steven D. Podos, Joel Charles Barrish, Hetal Kocinsky, Michael Geffner, Avinash Phadke, Mingjun Huang, Ifode Ajari, Manuel Galvan, Robert A. Brodsky, Yongsen Zhao, Amanda Luu, Guangwei Yang
Publikováno v:
Molecular Immunology. 89:200-201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3f0dae4efe56c43e857dcd969e195aae
https://doi.org/10.1016/j.molimm.2017.06.226
https://doi.org/10.1016/j.molimm.2017.06.226