Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Amanda L. Wright"'
Autor:
Maxinne Watchon, Amanda L. Wright, Holly I. Ahel, Katherine J. Robinson, Stuart K. Plenderleith, Andrea Kuriakose, Kristy C. Yuan, Angela S. Laird
Publikováno v:
Molecular Brain, Vol 17, Iss 1, Pp 1-15 (2024)
Abstract Machado-Joseph disease (MJD), also known as spinocerebellar ataxia type 3, is a fatal neurodegenerative disease that causes loss of balance and motor co-ordination, eventually leading to paralysis. It is caused by the autosomal dominant inhe
Externí odkaz:
https://doaj.org/article/6f50372d2c4746069222f52115dcf314
Autor:
Rebecca San Gil, Dana Pascovici, Juliana Venturato, Heledd Brown-Wright, Prachi Mehta, Lidia Madrid San Martin, Jemma Wu, Wei Luan, Yi Kit Chui, Adekunle T. Bademosi, Shilpa Swaminathan, Serey Naidoo, Britt A. Berning, Amanda L. Wright, Sean S. Keating, Maurice A. Curtis, Richard L. M. Faull, John D. Lee, Shyuan T. Ngo, Albert Lee, Marco Morsch, Roger S. Chung, Emma Scotter, Leszek Lisowski, Mehdi Mirzaei, Adam K. Walker
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-23 (2024)
Abstract Understanding the mechanisms that drive TDP-43 pathology is integral to combating amyotrophic lateral sclerosis (ALS), frontotemporal lobar degeneration (FTLD) and other neurodegenerative diseases. Here we generated a longitudinal quantitati
Externí odkaz:
https://doaj.org/article/4c4d2aa5f2d24e1cbc0429058653faa3
Autor:
Amanda L. Wright, Lyndsey M. Konen, Bruce G. Mockett, Gary P. Morris, Anurag Singh, Lisseth Estefania Burbano, Luke Milham, Monica Hoang, Raphael Zinn, Rose Chesworth, Richard P. Tan, Gordon A. Royle, Ian Clark, Steven Petrou, Wickliffe C. Abraham, Bryce Vissel
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-25 (2023)
Abstract Background RNA editing at the Q/R site of GluA2 occurs with ~99% efficiency in the healthy brain, so that the majority of AMPARs contain GluA2(R) instead of the exonically encoded GluA2(Q). Reduced Q/R site editing increases AMPA receptor ca
Externí odkaz:
https://doaj.org/article/b9e4dab9637d4341b888d7fc34854075
Autor:
Lyndsey M. Konen, Amanda L. Wright, Gordon A. Royle, Gary P. Morris, Benjamin K. Lau, Patrick W. Seow, Raphael Zinn, Luke T. Milham, Christopher W. Vaughan, Bryce Vissel
Publikováno v:
Molecular Brain, Vol 13, Iss 1, Pp 1-19 (2020)
Abstract Calcium (Ca2+)-permeable AMPA receptors may, in certain circumstances, contribute to normal synaptic plasticity or to neurodegeneration. AMPA receptors are Ca2+-permeable if they lack the GluA2 subunit or if GluA2 is unedited at a single nuc
Externí odkaz:
https://doaj.org/article/b5bc7dc91fc245ddbc739f87f12ef95c
Autor:
Wei Luan, Amanda L. Wright, Heledd Brown-Wright, Sheng Le, Rebecca San Gil, Lidia Madrid San Martin, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Adam K. Walker
Publikováno v:
Molecular Psychiatry.
TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% of amyotrophic lateral sclerosis (ALS) and nearly half of frontotemporal dementia (FTD) cases. The pathogenic mechanisms of TDP-43 dysfunction are poorly understood, however,
Publikováno v:
Oncology Issues. 36:32-39
Autor:
Wei Luan, Amanda L. Wright, Heledd Brown-Wright, Sheng Le, Rebecca San Gil, Lidia Madrid San Martin, Karen Ling, Paymaan Jafar-Nejad, Frank Rigo, Adam K. Walker
TAR DNA binding protein 43 (TDP-43) pathology is a key feature of over 95% of amyotrophic lateral sclerosis (ALS) and nearly half of frontotemporal dementia (FTD) cases. The pathogenic mechanisms of TDP-43 dysfunction are poorly understood, however a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7aba232ca5f0e0161e63549a7f2c677
https://doi.org/10.1101/2022.08.08.503119
https://doi.org/10.1101/2022.08.08.503119
Autor:
Zhipeng Yang, Haigang Wu, Jeng-Wei Lu, Xing-Jie Liang, Amanda L. Wright, Albert Lee, Xue Xia, Meng Zheng, Yingze Wang, Shizhu Chen, Yang Liu, Jinchao Zhang, Huijun Yin, Weimin Ruan
Publikováno v:
ACS applied bio materials. 2(1)
RNA interference (RNAi) is an emerging therapeutic modality for tumors. However, lack of a safe and efficient small interfering RNA (siRNA) delivery system limits its clinical application. Here, we report a bioreducible and less-cationic siRNA delive
Autor:
Sarah J, Baracz, Katherine J, Robinson, Amanda L, Wright, Anita J, Turner, Iain S, McGregor, Jennifer L, Cornish, Nicholas A, Everett
Publikováno v:
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 47(8)
Early life stress (ELS) is associated with perturbed neural development and augmented vulnerability to mental health disorders, including addiction. How ELS changes the brain to increase addiction risk is poorly understood, and there are no therapies
Autor:
Hossai Gul, Roger S. Chung, Owen Watson, Thomas J. Hedl, Paul A. Della Gatta, Sean S. Keating, Britt A. Berning, Adam K. Walker, Winonah R. Riddell, Julie D. Atkin, Catherine A. Blizzard, Kelly R. Jacobs, Bingyang Shi, Marco Morsch, Amanda L. Wright, Rebecca San Gil, Albert Lee, Sheng Le, Prachi Mehta, Juliana Venturato
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::94e45cf72ad3d3e91e813216eaafa789
https://doi.org/10.1111/ejn.15422/v2/response1
https://doi.org/10.1111/ejn.15422/v2/response1