Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Amanda L. Whiting"'
Autor:
Hiroaki Fujita, Akira Tokunaga, Satoshi Shimizu, Amanda L. Whiting, Francisco Aguilar-Alonso, Kenji Takagi, Erik Walinda, Yoshiteru Sasaki, Taketo Shimokawa, Tsunehiro Mizushima, Izuru Ohki, Mariko Ariyoshi, Hidehito Tochio, Federico Bernal, Masahiro Shirakawa, Kazuhiro Iwai
Publikováno v:
Cell Reports, Vol 23, Iss 4, Pp 1192-1204 (2018)
Summary: The linear ubiquitin chain assembly complex (LUBAC) participates in inflammatory and oncogenic signaling by conjugating linear ubiquitin chains to target proteins. LUBAC consists of the catalytic HOIP subunit and two accessory subunits, HOIL
Externí odkaz:
https://doaj.org/article/7c862e83f5e5418699f786a096c66df4
Autor:
Satoshi Shimizu, Kazuhiro Iwai, Akira Tokunaga, Kenji Takagi, Federico Bernal, Tsunehiro Mizushima, Izuru Ohki, Hiroaki Fujita, Francisco Aguilar-Alonso, Taketo Shimokawa, Masahiro Shirakawa, Yoshiteru Sasaki, Hidehito Tochio, Mariko Ariyoshi, Amanda L. Whiting, Erik Walinda
Publikováno v:
Cell reports
Cell Reports, Vol 23, Iss 4, Pp 1192-1204 (2018)
Cell Reports, Vol 23, Iss 4, Pp 1192-1204 (2018)
SUMMARY The linear ubiquitin chain assembly complex (LUBAC) participates in inflammatory and oncogenic signaling by conjugating linear ubiquitin chains to target proteins. LUBAC consists of the catalytic HOIP subunit and two accessory subunits, HOIL-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34fcb4b5a10c5f106a0d62ec455e1769
http://hdl.handle.net/2433/230872
http://hdl.handle.net/2433/230872
Publikováno v:
Bioorganic & Medicinal Chemistry. 26:1179-1188
Linear ubiquitylation, in which ubiquitin units are covalently linked through N- and C-terminal amino acids, is a unique cellular signaling mechanism. This process is controlled by a single E3 ubiquitin ligase, the linear ubiquitin chain assembly com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05aa90660971c4ecc76f092c81f37e0
https://doi.org/10.1016/j.bmc.2017.11.047
https://doi.org/10.1016/j.bmc.2017.11.047
Autor:
James McFarlane, Amanda L. Whiting, Irina Paci, Joseph A. Lyons, Fraser Hof, Brendan D. Snarr, Róise E. McGovern, Peter B. Crowley
Publikováno v:
'Chemical Science ', vol: 6, pages: 442-449 (2015)
Chemical Science
Chemical Science
X-ray crystallography reveals how a calixarene can bind to dimethyllysine to form a complex with features similar to the aromatic cage motif of a chromodomain bound to a histone tail.
Lysine is a ubiquitous residue on protein surfaces. Post tran
Lysine is a ubiquitous residue on protein surfaces. Post tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e88914bb107bb3d0472b0acdc22f9230
https://doi.org/10.1039/c4sc02383h
https://doi.org/10.1039/c4sc02383h
Autor:
Amanda L. Whiting, Goverdhan Mehta, Fraser Hof, Subrata Jana, Hoong-Kun Fun, Anita Hazra, Shyamaprosad Goswami, Saikat Sen
Publikováno v:
Supramolecular Chemistry. 24:385-391
The interaction between a series of bidentate, amide-functionalised 8-oxyquinoline receptors and coordinating anions is investigated. Anion recognition properties and conformations were studied by solid-state structures, Hartree–Fock calculations a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ca8411adbd5aa87cddaeb9d852f26ba
https://doi.org/10.1080/10610278.2012.676179
https://doi.org/10.1080/10610278.2012.676179
Autor:
Christopher N. Boddy, Christina Moi, Daniel I. Pau, Blaze M. Pharoah, Amanda L. Whiting, Sterling R. Payne, Federico Bernal, Ye Joon Kim
Publikováno v:
Cell Chemical Biology. 25:1059-1066.e4
In response to environmental and other stresses, the σ(54) subunit of bacterial RNA polymerase (RNAP) controls expression of several genes which play a significant role in the virulence of both plant and animal pathogens. Recruitment of σ(54) to RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8f86a9483790c331b406cfbd31f7503
https://doi.org/10.1016/j.chembiol.2018.05.007
https://doi.org/10.1016/j.chembiol.2018.05.007
Publikováno v:
Cancer Research. 77:5235-5235
The linear ubiquitin chain assembly complex (LUBAC) is the only E3 ubiquitin ligase known to generate linear polyubiquitin chains in vitro. LUBAC is composed of three proteins - HOIL-1L, HOIP and SHARPIN - of which the interaction between HOIL-1L and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c4957c3a3fd93cc6e6aa9c4dac24f73
https://doi.org/10.1158/1538-7445.am2017-5235
https://doi.org/10.1158/1538-7445.am2017-5235
Publikováno v:
Cancer Research. 77:4137-4137
The linear ubiquitin chain assembly complex (LUBAC) is the only known linear ubiquitin ligase whose function is dependent on the interaction of three proteins: HOIL, HOIP and SHARPIN. The activity of this ubiquitin ligase has been linked to a maligna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e1ab19796449aa098479ca7751b5021d
https://doi.org/10.1158/1538-7445.am2017-4137
https://doi.org/10.1158/1538-7445.am2017-4137
Autor:
Dennis D. Weisenburger, Joseph M. Connors, Elaine S. Jaffe, Randy D. Gascoyne, Erlend B. Smeland, George E. Wright, Kazuhiro Iwai, Joseph J. Mitala, Federico Bernal, Adrian Wiestner, Rita M. Braziel, Hong Zhao, Jan Delabie, Elias Campo, Amanda L. Whiting, Lisa M. Rimsza, Andreas Rosenwald, James R. Cook, Louis M. Staudt, Roland Schmitz, Weihong Xu, Michele Ceribelli, Yandan Yang, Michael J. Kruhlak, Wing C. Chan, Wenming Xiao, German Ott, Yibin Yang, Raymond R. Tubbs
Publikováno v:
Cancer discovery. 4(4)
Constitutive activation of NF-κB is a hallmark of the activated B cell–like (ABC) subtype of diffuse large B-cell lymphoma (DLBCL), owing to upstream signals from the B-cell receptor (BCR) and MYD88 pathways. The linear polyubiquitin chain assembl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787b6db71af886ff9cbd557237259c37
https://pubmed.ncbi.nlm.nih.gov/24706658
https://pubmed.ncbi.nlm.nih.gov/24706658
Publikováno v:
Tetrahedron Letters. 50:7035-7037
The binding of quaternary ammonium guests to a flexible, indole-based host has been studied in both aqueous and organic solvents. Binding was shown to depend strongly on the hydrophobic effect and less on the cation–π interaction.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c7aa3ae54422745e9e24a517bed6eaf
https://doi.org/10.1016/j.tetlet.2009.09.161
https://doi.org/10.1016/j.tetlet.2009.09.161