Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Amanda L. Richer"'
Autor:
Timothy G. Whitsett, Landon J. Inge, Vashti M. Carson, Kelley O'Brien, Jacqueline M. Cala, Amanda L. Richer
Active AMPK protein expression in H2030 isogenic cell lines treated with AZD1775 or 2DG.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e58ef3d6432c420ca144bd51501f22e
https://doi.org/10.1158/0008-5472.22414199.v1
https://doi.org/10.1158/0008-5472.22414199.v1
Autor:
Timothy G. Whitsett, Landon J. Inge, Vashti M. Carson, Kelley O'Brien, Jacqueline M. Cala, Amanda L. Richer
Figure legends for supplemental figures 1 and 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::478702c3c1e328a430f5d82e24a1560e
https://doi.org/10.1158/0008-5472.22414196
https://doi.org/10.1158/0008-5472.22414196
Autor:
Timothy G. Whitsett, Landon J. Inge, Vashti M. Carson, Kelley O'Brien, Jacqueline M. Cala, Amanda L. Richer
Treatment scheme for the in vivo experiments along with representative bioluminescent imaging.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74913ce5654087350ffe36166b0bc032
https://doi.org/10.1158/0008-5472.22414202.v1
https://doi.org/10.1158/0008-5472.22414202.v1
Publikováno v:
Nucleic Acids Research
Methods to measure heterogeneity among cells are rapidly transforming our understanding of biology but are currently limited to molecular abundance measurements. We developed an approach to simultaneously measure biochemical activities and mRNA abund
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6baf4fd1650d6fb6af8685a4fb36d30
https://doi.org/10.1101/820233
https://doi.org/10.1101/820233
Publikováno v:
Molecular Cancer Therapeutics. 18:A092-A092
Purpose of Study: DNA damage has been shown to have a strong link to the origin and propagation of many cancers. Specific damages to different DNA repair pathways within the cell spell accumulations of DNA damaging events and alterations in normal bi
Publikováno v:
Pharmacogenomics and Personalized Medicine
Lung cancer remains the leading cause of cancer-related mortality worldwide. The application of next-generation genomic technologies has offered a more comprehensive look at the mutational landscape across the different subtypes of non-small cell lun
Autor:
Jacqueline M. Cala, Kelley O’Brien, Amanda L. Richer, Vashti M. Carson, Timothy G. Whitsett, Landon J. Inge
Publikováno v:
Cancer research. 77(17)
G1–S checkpoint loss contributes to carcinogenesis and increases reliance upon the G2–M checkpoint for adaptation to stress and DNA repair, making G2–M checkpoint inhibition a target for novel therapeutic development. AZD1775, an inhibitor agai
Publikováno v:
The Journal of thoracic and cardiovascular surgery. 149(4)
Objective Obesity has been linked to esophageal adenocarcinoma (EAC). We hypothesize that adipokines, which are altered by obesity, could affect EAC growth rates and potentially serve as biomarkers of disease and targets for treatment. We have develo
Autor:
Timothy G. Whitsett, Jacqueline M. Friel, Amanda L. Richer, Landon J. Inge, Aaron J. Fowler, Nhan L. Tran, Ross M. Bremner, Michael A. Smith
Publikováno v:
Cancer letters. 352(2)
Five-year survival rates for non-small cell lung cancer (NSCLC) have seen minimal improvement despite aggressive therapy with standard chemotherapeutic agents, indicating a need for new treatment approaches. Studies show inactivating mutations in the
Autor:
Timothy G. Whitsett, Kelley O’Brien, Landon J. Inge, Amanda L. Richer, Jacqueline M. Cala, Vashti M. Carson
Publikováno v:
Cancer Research. 76:2817-2817
Within eukaryotic cells, the G1/S and G2/M cell cycle checkpoints activate in response to intracellular or extracellular stress to prevent defects in DNA synthesis and mitosis. Deregulation of the cell cycle is a fundamental characteristic of cancer,