Dynein acts to cluster glutamate receptors and traffic the PIP5 kinase, Skittles, to regulate postsynaptic membrane organization at the neuromuscular junction

Autor: Amanda L. Neisch, Adam W. Avery, Thomas S. Hays, Thomas Pengo, Mingang Li

Cytoplasmic dynein is essential in motoneurons for retrograde cargo transport that sustains neuronal connectivity. Little, however, is known about dynein’s function on the postsynaptic side of the circuit. Here we report distinct postsynaptic roles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::18a70d297a2dcf70df2554aef641c8a0
https://doi.org/10.1101/2021.09.27.462070

List of Contributors

Autor: Adam W. Avery, Gordon K. Chan, Anudariya B. Dean, Paurav B. Desai, Ian R. Gibbons, Thomas S. Hays, Edward H. Hinchcliffe, Yuqing Hou, Emily L. Hunter, Juyeon Hwang, Takashi Ishikawa, Rupam Jha, Ritsu Kamiya, Stephanie A. Ketcham, K. Kevin Pfister, Stephen M. King, Cody W. Lewis, Min-Gang Li, Richard J. McKenney, David R. Mitchell, Amanda L. Neisch, Mary E. Porter, Winfield S. Sale, Trina A. Schroer, Chikako Shingyoji, Thomas Surrey, Noriko Ueki, Richard B. Vallee, Kevin T. Vaughan, Ken-ichi Wakabayashi, Bill Wickstead, Maureen Wirschell, George B. Witman, Xin Xiang, Toshiki Yagi, Lionel Berthoux, Andrew P. Carter, Amrita Dawn, David J. Doobin, Mike Fainzilber, Elizabeth M.C. Fisher, Ken’ya Furuta, Veikko F. Geyer, Steven P. Gross, William O. Hancock, Kent L. Hill, Erika L.F. Holzbaur, Jonathon Howard, Simon Imhof, Kazuo Inaba, Frank Jülicher, Tarun M. Kapoor, Sandip Koley, Christine M. Lightcap, Niki T. Loges, Miroslav P. Milev, Hannah M. Mitchison, Armen J. Moughamian, Andrew J. Mouland, Kazuhiro Oiwa, Heymut Omran, Stephen H. Pilder, Michael Price, Babu J.N. Reddy, Hitoshi Sakakibara, Pablo Sartori, Helgo Schmidt, Miriam Schmidts, Amanda E. Siglin, Joseph H. Sisson, Jonathan B. Steinman, George T. Shubeita, Marco Terenzio, John B. Vincent, John C. Williams, Fan Yang, Xaojian Yao, Ahmet Yildiz

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3a4fc3e596df0e76a7b86db619d9e001
https://doi.org/10.1016/b978-0-12-809471-6.01002-0

Coordination of autophagosome-lysosome fusion and transport by a Klp98A-Rab14 complex

Autor: Jung Kim, Melissa K. Gardner, Thomas S. Hays, Amanda L. Neisch, Carlos I. Ayala, Christopher R. Braden, Thomas P. Neufeld, Caroline Mauvezin, Abigail Beltrame

Publikováno v: Journal of Cell Science.

Degradation of cellular material by autophagy is essential for cell survival and homeostasis, and requires intracellular transport of autophagosomes to encounter acidic lysosomes through unknown mechanisms. Here we identify the PX domain-containing k

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7645a706fa5bd26cc8d300a98f4c11c9
https://doi.org/10.1242/jcs.175224

Conundrum, an ARHGAP18 orthologue, regulates RhoA and proliferation through interactions with Moesin

Autor: Etienne Formstecher, Amanda L. Neisch, Richard G. Fehon

Publikováno v: Molecular Biology of the Cell

Moesin, an ERM protein, negatively regulates RhoA by recruiting Conundrum/Rho GTPase–activating protein 18 to the apical cell cortex, thereby activating its RhoGAP function. Surprisingly, the data also show that activated Conundrum promotes cell pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b9fbc98faad4f6fd1d42dff4c89dcc7
https://pubmed.ncbi.nlm.nih.gov/23468526

Rho1 regulates apoptosis via activation of the JNK signaling pathway at the plasma membrane

Autor: Richard G. Fehon, Olga Speck, Amanda L. Neisch, Beth Stronach

Publikováno v: The Journal of Cell Biology

In the absence of moesin, RhoA slips out of its normal role as a GTPase to activate the JNK MAPK pathway and spur apoptosis.
Precisely controlled growth and morphogenesis of developing epithelial tissues require coordination of multiple factors,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78c2e9cecddcf86ae8ec26f398319162