Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Amanda L. Kemmerer"'
Autor:
Samuel L. Graham, Joseph G. Bruno, Scott D. Mosser, Harold G. Selnick, Sandra M. Sanabria-Bohórquez, Christopher A. Salvatore, Rebecca B. White, Melody Mcwherter, Hong Fan, Mangay Williams, Jacquelynn J. Cook, Kerry Riffel, Richard Hargreaves, Ian M. Bell, Craig A. Stump, Eric L. Moore, Liza Gantert, Steven N. Gallicchio, Mona Purcell, C. Blair Zartman, Amanda L. Kemmerer, Eric D. Hostetler, Donnette D. Staas, Stefanie A. Kane
Publikováno v:
ACS Medicinal Chemistry Letters. 4:863-868
Rational modification of the potent calcitonin gene-related peptide (CGRP) receptor antagonist MK-3207 led to a series of analogues with enhanced CNS penetrance and a convenient chemical handle for introduction of a radiolabel. A number of (11)C-trac
Autor:
Samuel L. Graham, Christine Fandozzi, Eric L. Moore, Donnette D. Staas, Ian M. Bell, Nova Sain, Joseph G. Bruno, Steven N. Gallicchio, Harold G. Selnick, Christopher A. Salvatore, Mark O. Urban, Rebecca B. White, Matthew M. Zrada, Amy Calamari, C. Blair Zartman, Amanda L. Kemmerer, Joseph P. Vacca, Stefanie A. Kane, Craig A. Stump, Scott D. Mosser
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3941-3945
Rational modification of the clinically tested CGRP receptor antagonist MK-3207 (3) afforded an analogue with increased unbound fraction in rat plasma and enhanced aqueous solubility, 2-[(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]
Autor:
Amy G. Quigley, Daniel V. Paone, Melody Mcwherter, Andrew Danziger, Brendan M. Crowley, Mark E. Fraley, Danny Gauvreau, Dan Cui, Karsten Menzel, J. Christopher Culberson, Joseph G. Bruno, Vijay Bhasker G. Reddy, Christopher A. Salvatore, Ian M. Bell, Craig A. Stump, Christopher S. Burgey, Eric L. Moore, Stefanie A. Kane, Amanda L. Kemmerer, Scott D. Mosser, Christine Fandozzi, Diem N. Nguyen, Craig M. Potteiger, Harold G. Selnick, Rebecca B. White
Publikováno v:
Bioorganicmedicinal chemistry letters. 25(21)
In our efforts to develop CGRP receptor antagonists as backups to MK-3207, 2, we employed a scaffold hopping approach to identify a series of novel oxazolidinone-based compounds. The development of a structurally diverse, potent (20, cAMP+HS IC50=0.6