Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amanda L. Hughes"'
Autor:
Keri K. Stephens, Anastazja G. Harris, Amanda L. Hughes, Carolyn E. Montagnolo, Karim Nader, S. Ashley Stevensons, Tara Tasuji, Yifan Xu, Hemant Purohit, Christopher W. Zobel
Publikováno v:
Human-Machine Communication Journal, Vol 6, Pp 65-85 (2023)
Humans play an integral role in identifying important information from social media during disasters. While human annotation of social media data to train machine learning models is often viewed as human-computer interaction, this study interrogates
Externí odkaz:
https://doaj.org/article/14bd1b0924c24a3c9420830a4eaa7f71
Autor:
Amanda L. Hughes, Tom Owen-Hughes
Publikováno v:
Cell Reports, Vol 18, Iss 9, Pp 2075-2076 (2017)
In this issue of Cell Reports, Sen et al. and Dutta et al. reveal the modularity of the yeast SWI/SNF chromatin remodeling complex and show that loss of different subunits leads to distinct consequences for gene expression. : In this issue of Cell Re
Externí odkaz:
https://doaj.org/article/8579187094cb4de1b02c7cd4f31aa593
Autor:
Ramasubramanian Sundaramoorthy, Amanda L Hughes, Hassane El-Mkami, David G Norman, Helder Ferreira, Tom Owen-Hughes
Publikováno v:
eLife, Vol 7 (2018)
ATP-dependent chromatin remodelling proteins represent a diverse family of proteins that share ATPase domains that are adapted to regulate protein–DNA interactions. Here, we present structures of the Saccharomyces cerevisiae Chd1 protein engaged wi
Externí odkaz:
https://doaj.org/article/7c5b67c7e4c94440952e5440eae4aefa
Autor:
Ramasubramanian Sundaramoorthy, Amanda L Hughes, Vijender Singh, Nicola Wiechens, Daniel P Ryan, Hassane El-Mkami, Maxim Petoukhov, Dmitri I Svergun, Barbara Treutlein, Salina Quack, Monika Fischer, Jens Michaelis, Bettina Böttcher, David G Norman, Tom Owen-Hughes
Publikováno v:
eLife, Vol 6 (2017)
The yeast Chd1 protein acts to position nucleosomes across genomes. Here, we model the structure of the Chd1 protein in solution and when bound to nucleosomes. In the apo state, the DNA-binding domain contacts the edge of the nucleosome while in the
Externí odkaz:
https://doaj.org/article/990cf61399f44bdea9c20e0939ed572f
Autor:
Yu Zhao, Camila Coelho, Amanda L. Hughes, Luciana Lazar-Stefanita, Sandy Yang, Aaron N. Brooks, Roy S. K. Walker, Weimin Zhang, Stephanie Lauer, Cindy Hernandez, Leslie A. Mitchell, Neta Agmon, Yue Shen, Joseph Sall, Viola Fanfani, Anavi Jalan, Jordan Rivera, Feng-Xia Liang, Giovanni Stracquadanio, Lars M. Steinmetz, Yizhi Patrick Cai, Jef D. Boeke
The Sc2.0 project is building a eukaryotic synthetic genome from scratch, incorporating thousands of designer features. A major milestone has been achieved with the assembly of all individual Sc2.0 chromosomes. Here, we describe the consolidation of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1e3a2c373b173cbc37bf13b941f94497
https://doi.org/10.1101/2022.04.11.486913
https://doi.org/10.1101/2022.04.11.486913
Autor:
Aaron N. Brooks, Amanda L. Hughes, Sandra Clauder-Münster, Leslie A. Mitchell, Jef D. Boeke, Lars M. Steinmetz
Publikováno v:
Science
Sequence features of genes and their flanking regulatory regions are determinants of RNA transcript isoform expression and have been used as context-independent plug-and-play modules in synthetic biology. However, genetic context—including the adja
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebbd9d84828be521276ef4238830ea65
https://pubmed.ncbi.nlm.nih.gov/35314808
https://pubmed.ncbi.nlm.nih.gov/35314808
Publikováno v:
Science Advances, Vol. 6, No 36 (2020) P. eabb0333
Science Advances
Science Advances
Histone turnover during gene transcription is mediated by regulatory proteins, not by the transcription machinery.
Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new
Transcription in eukaryotes correlates with major chromatin changes, including the replacement of old nucleosomal histones by new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef9707318953a5449e027b6fd189b081
https://doi.org/10.1126/sciadv.abb0333
https://doi.org/10.1126/sciadv.abb0333
Autor:
Bernard D Horn, Elizabeth A Pendergast, Megan Beam, John F. Brandsema, Amanda L Hughes, Jennifer N. Jones, Christina Z Thompson, Allan M. Glanzman, Michael King
Publikováno v:
Journal of neuromuscular diseases. 7(3)
Background Boys with dystrophinopathies (DMD) are at increased risk of low bone mineral density and fracture. Femoral fracture is the most common extremity fracture and is accompanied by significant risk of functional loss. Care considerations for DM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::334b0318ecfd7759096f39e1aaf7bd3c
https://pubmed.ncbi.nlm.nih.gov/32417791
https://pubmed.ncbi.nlm.nih.gov/32417791
Autor:
Amanda L Hughes, Ramasubramanian Sundaramoorthy, Hassane El-Mkami, David Norman, Tom Owen-Hughes
ATP-dependent chromatin remodelling proteins represent a diverse family of proteins that share ATPase domains that are adapted to regulate protein-DNA interactions. Here we present structures of the yeast Chd1 protein engaged with nucleosomes in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fea7a0d24e482a69c7e46ae6be98708f