Výsledky vyhledávání - "Amanda L. Fortier"

Modulation of imprinted gene expression following superovulation

Autor: Kirsten M. Niles, Jacquetta M. Trasler, Serge McGraw, Amanda L. Fortier, Mylène Landry, Flavia L. Lopes

Publikováno v: Molecular and Cellular Endocrinology. 388:51-57

Although assisted reproductive technologies increase the risk of low birth weight and genomic imprinting disorders, the precise underlying causes remain unclear. Using a mouse model, we previously showed that superovulation alters the expression of i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6334c934f6e48b1d6f449f0c117bff04
https://doi.org/10.1016/j.mce.2014.03.003

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Diverse subtypes and developmental origins of trophoblast giant cells in the mouse placenta

Autor: David G. Simmons, James C. Cross, Amanda L. Fortier

Publikováno v: Developmental Biology. 304:567-578

Trophoblast giant cells (TGCs) are the first terminally differentiated subtype to form in the trophoblast cell lineage in rodents. In addition to mediating implantation, they are the main endocrine cells of the placenta, producing several hormones wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73d0b323cfd93543e125563883cf2ca4
https://doi.org/10.1016/j.ydbio.2007.01.009

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Betaine homocysteine methyltransferase is active in the mouse blastocyst and promotes inner cell mass development

Autor: Jacquetta M. Trasler, Michael Lever, Sandy Slow, Baohua Zhang, Jay M. Baltz, Megan Kooistra, Amanda L. Fortier, Martin B. Lee, Timothy A. Garrow

Publikováno v: The Journal of biological chemistry. 287(39)

Methyltransferases are an important group of enzymes with diverse roles that include epigenetic gene regulation. The universal donor of methyl groups for methyltransferases is S-adenosylmethionine (AdoMet), which in most cells is synthesized using me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d157df45b138d5109d001a943fed3ab
https://pubmed.ncbi.nlm.nih.gov/22847001

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Potential Epigenetic Consequences Associated with Assisted Reproduction

Autor: Jacquetta M. Trasler, Amanda L. Fortier

Publikováno v: Epigenetics and Human Reproduction ISBN: 9783642147722

Assisted Reproductive Technology (ART) includes an array of treatments designed to bypass fertility problems in both men and women in order to achieve conception. These methods vary from hormonal stimulation of follicular development and ovulation in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b234f6ad438d4f82be8bc37debb1583d
https://doi.org/10.1007/978-3-642-14773-9_1

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Reproductive and epigenetic outcomes associated with aging mouse oocytes

Autor: Nicole Darricarrère, D. R. Arnold, Donovan Chan, Jacquetta M. Trasler, Flavia L. Lopes, Amanda L. Fortier

Publikováno v: Human molecular genetics. 18(11)

Female aging entails a decline in fertility in mammals, manifested by reduced oocyte reserves and poor oocyte quality accompanied by chromosomal anomalies and reduced litter size. In addition to compromised genetic integrity, recent studies suggest t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f0b9f55e7df61578666a6ea2eba071
https://pubmed.ncbi.nlm.nih.gov/19293340

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Superovulation alters the expression of imprinted genes in the midgestation mouse placenta

Autor: Flavia L. Lopes, Nicole Darricarrère, Jacquetta M. Trasler, Josée Martel, Amanda L. Fortier

Publikováno v: Human molecular genetics. 17(11)

Imprinted genes play important roles in embryonic growth and development as well as in placental function. Many imprinted genes acquire their epigenetic marks during oocyte growth, and this period may be susceptible to epigenetic disruption following

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8ab4c32ff2c28a2f2a0d5513a118b04
https://pubmed.ncbi.nlm.nih.gov/18287259

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Placental insufficiencies in cloned animals - a workshop report

Autor: Amanda L. Fortier, Christiane Pfarrer, Maria Angélica Miglino, Lawrence C. Smith, Réjean Lefebvre, D. R. Arnold

Publikováno v: Placenta. 29

This workshop focused on describing clinical problems identified in the placentae of cloned animals and some of the potential biological mechanisms by which these anomalies arise. It was shown that placental anomalies related to somatic cell nuclear

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aab784ad9815221089758fc7aab68882
https://pubmed.ncbi.nlm.nih.gov/18281092

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