Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amanda L. Cirello"'
Publikováno v:
Drug Metabolism Letters
Background: Acyl glucuronides of xenobiotics have been a subject of wide interest from the pharmaceutical industry with respect to biochemical reactivity, hepatic disposition, and enterohepatic cir-culation. The reactivity and lack of stability of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4079046cf68ca5459e4f90dc82d47a13
https://doi.org/10.2174/1872312812666180611113656
https://doi.org/10.2174/1872312812666180611113656
Autor:
Valerie M. Kramlinger, Christine E. Dunne, Amanda L. Cirello, Jennifer L. Dumouchel, Upendra A. Argikar, Bindi Sohal, Mithat Gunduz
Publikováno v:
Journal of Pharmaceutical Sciences. 106:2276-2281
The liver is known to be the principal site of drug metabolism. Depending on the route of administration, especially in cases of topical and local delivery, evaluation of local drug metabolism in extrahepatic tissues is vital to assess fraction of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8e627cb1bbe230f9ee75798315c932
https://doi.org/10.1016/j.xphs.2017.03.008
https://doi.org/10.1016/j.xphs.2017.03.008
Autor:
Mithat Gunduz, Christine E. Dunne, Upendra A. Argikar, Amanda L. Cirello, Jennifer L. Dumouchel
Publikováno v:
Drug Metabolism and Pharmacokinetics. 32:121-126
Oral ketoconazole is clinically administered for treatment of severe cases for fungal keratitis. Pharmacodynamics and efficacy of oral and topical (ocular) ketoconazole have been explored in rabbit. However, metabolism of ketoconazole in the eye in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34f9dbb40299e8d6702a6c07d9967a3
https://doi.org/10.1016/j.dmpk.2016.11.001
https://doi.org/10.1016/j.dmpk.2016.11.001
Autor:
Christine E. Dunne, Jennifer L. Dumouchel, Mithat Gunduz, Chitra Saran, Amanda L. Cirello, Upendra A. Argikar
Publikováno v:
Drug Metabolism and Disposition. 44:1304-1312
Although ocular transport and delivery have been well studied, metabolism in the eye is not well documented, even for clinically available medications such as levobunolol, a potent and nonselective β-adrenergic receptor antagonist. Recently, we repo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58062a08f345e5d4ec2b6219d021af7c
https://doi.org/10.1124/dmd.116.070458
https://doi.org/10.1124/dmd.116.070458
Publikováno v:
Drug Metabolism Letters. 11
Background 4-(piperazin-1-yl)-8-(trifluoromethyl)pyrido[2,3-e][1,2,4]triazolo[4,3-a]pyrazine (1) is a small-molecule which demonstrated a sub-nM inhibitory potency toward the histamine H4 receptor (H4R). However, it was found to be mutagenic in an in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec3e8bf5ceb9b446a458abff5a8109e8
https://doi.org/10.2174/1872312811666171106151730
https://doi.org/10.2174/1872312811666171106151730
Autor:
Mithat Gunduz, Amanda L. Cirello, Upendra A. Argikar, Ann Brown, Christine E. Dunne, Jennifer L. Dumouchel, Jaimie Spear, Valerie M. Kramlinger
Publikováno v:
Drug Metabolism Letters. 11
BACKGROUND Timolol is clinically administered topically (ocular) to reduce intraocular pressure and treat open-angle glaucoma. Ocular administration of timolol in low doses (0.5% w/v in the form of eye drops) has led to challenges for in vivo metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58689710fe6c9a582c2bbdbcd2837a87
https://doi.org/10.2174/1872312811666170911122919
https://doi.org/10.2174/1872312811666170911122919
Autor:
Charles Ansah, Caroline Rynn, Colin W. Wright, Jaimie Spear, Arnold Donkor Forkuo, David Pearson, Werner Gertsch, Adam Amaral, Amanda L. Cirello
Publikováno v:
BMC Pharmacology & Toxicology
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-9 (2017)
BMC Pharmacology and Toxicology, Vol 18, Iss 1, Pp 1-9 (2017)
Background This study aims at characterizing the in vitro metabolism of cryptolepine using human and rat hepatocytes, identifying metabolites in rat plasma and urine after a single cryptolepine dose, and evaluating the single-dose oral and intravenou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26751d051134002108d5462232d1de19
https://doi.org/10.1186/s40360-017-0188-8
https://doi.org/10.1186/s40360-017-0188-8
Publikováno v:
Food Chemistry. 135:1929-1937
Blueberries have been extensively researched, but there are limited studies on other parts of the plant. Here we report the first phytochemical examination of highbush blueberry (Vaccinium corymbosum) flowers, which yielded 21 phenolics. The compound
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d27f58101115bbb5078e0c9db4db15b4
https://doi.org/10.1016/j.foodchem.2012.06.056
https://doi.org/10.1016/j.foodchem.2012.06.056
Autor:
Mithat Gunduz, Amin Kamel, Jennifer L. Bushee, Upendra A. Argikar, Amanda L. Cirello, Franco Lombardo, Kevin Colizza, Shawn Harriman
Publikováno v:
Drug Metabolism and Disposition. 40:2074-2080
In vitro metabolite identification and GSH trapping studies in human liver microsomes were conducted to understand the bioactivation potential of compound 1 [2-(6-(4-(4-(2,4-difluorobenzyl)phthalazin-1-yl)piperazin-1-yl)pyridin-3-yl)propan-2-ol], an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::574c19fc6376fe4d18fc8b458a28fe68
https://doi.org/10.1124/dmd.112.046268
https://doi.org/10.1124/dmd.112.046268
Autor:
Dominik Hainzl, Tony D'Alessio, Jennifer L. Dumouchel, Vladimir Capka, Amanda L. Cirello, Mithat Gunduz, Upendra A. Argikar, Carl Uli Bialucha
Publikováno v:
Drug Metabolism and Pharmacokinetics. 33:S69
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ef158709d7c160be7d4771fabfa1707
https://doi.org/10.1016/j.dmpk.2017.11.231
https://doi.org/10.1016/j.dmpk.2017.11.231