Cosmic kidney disease: an integrated pan-omic, physiological and morphological study into spaceflight-induced renal dysfunction

Autor: Keith Siew, Kevin A. Nestler, Charlotte Nelson, Viola D’Ambrosio, Chutong Zhong, Zhongwang Li, Alessandra Grillo, Elizabeth R. Wan, Vaksha Patel, Eliah Overbey, JangKeun Kim, Sanghee Yun, Michael B. Vaughan, Chris Cheshire, Laura Cubitt, Jessica Broni-Tabi, Maneera Yousef Al-Jaber, Valery Boyko, Cem Meydan, Peter Barker, Shehbeel Arif, Fatemeh Afsari, Noah Allen, Mohammed Al-Maadheed, Selin Altinok, Nourdine Bah, Samuel Border, Amanda L. Brown, Keith Burling, Margareth Cheng-Campbell, Lorianna M. Colón, Lovorka Degoricija, Nichola Figg, Rebecca Finch, Jonathan Foox, Pouya Faridi, Alison French, Samrawit Gebre, Peter Gordon, Nadia Houerbi, Hossein Valipour Kahrood, Frederico C. Kiffer, Aleksandra S. Klosinska, Angela Kubik, Han-Chung Lee, Yinghui Li, Nicholas Lucarelli, Anthony L. Marullo, Irina Matei, Colleen M. McCann, Sayat Mimar, Ahmed Naglah, Jérôme Nicod, Kevin M. O’Shaughnessy, Lorraine Christine De Oliveira, Leah Oswalt, Laura Ioana Patras, San-huei Lai Polo, María Rodríguez-Lopez, Candice Roufosse, Omid Sadeghi-Alavijeh, Rebekah Sanchez-Hodge, Anindya S. Paul, Ralf Bernd Schittenhelm, Annalise Schweickart, Ryan T. Scott, Terry Chin Choy Lim Kam Sian, Willian A. da Silveira, Hubert Slawinski, Daniel Snell, Julio Sosa, Amanda M. Saravia-Butler, Marshall Tabetah, Erwin Tanuwidjaya, Simon Walker-Samuel, Xiaoping Yang, Yasmin, Haijian Zhang, Jasminka Godovac-Zimmermann, Pinaki Sarder, Lauren M. Sanders, Sylvain V. Costes, Robert A. A. Campbell, Fathi Karouia, Vidya Mohamed-Alis, Samuel Rodriques, Steven Lynham, Joel Ricky Steele, Sergio Baranzini, Hossein Fazelinia, Zhongquan Dai, Akira Uruno, Dai Shiba, Masayuki Yamamoto, Eduardo A.C.Almeida, Elizabeth Blaber, Jonathan C. Schisler, Amelia J. Eisch, Masafumi Muratani, Sara R. Zwart, Scott M. Smith, Jonathan M. Galazka, Christopher E. Mason, Afshin Beheshti, Stephen B. Walsh

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)

Abstract Missions into Deep Space are planned this decade. Yet the health consequences of exposure to microgravity and galactic cosmic radiation (GCR) over years-long missions on indispensable visceral organs such as the kidney are largely unexplored

Externí odkaz: https://doaj.org/article/314b862fbe6c4c54a23cb008317e48c9

Using mixed methods to establish tobacco treatment acceptability from the perspective of clients and clinicians of antenatal substance use services

Autor: Melissa A. Jackson, Penny Buykx, Amanda L. Brown, Amanda L. Baker, Adrian J. Dunlop, Gillian S. Gould

Publikováno v: Addiction Science & Clinical Practice, Vol 17, Iss 1, Pp 1-15 (2022)

Abstract Background Up to 95% of pregnant women with alcohol and other drug (AOD) problems also smoke tobacco. Challenging psychosocial circumstances and a lack of targeted tobacco interventions contribute to low rates of prenatal abstinence and more

Externí odkaz: https://doaj.org/article/a8e5eac40e754a828ba77978011e9236

Single midline incision approach for decompression of greater, lesser and third occipital nerves in migraine surgery

Autor: Danielle R. Olla, Kortni M. Kemper, Amanda L. Brown, Brian A. Mailey

Publikováno v: BMC Surgery, Vol 22, Iss 1, Pp 1-5 (2022)

Abstract Background The traditional approach for occipital migraine surgery encompasses three separate surgical incisions in the posterior neck to decompress the greater occipital nerves (GON), lesser occipital nerves (LON), and third occipital nerve

Externí odkaz: https://doaj.org/article/b5d5aee97f5a4de8901ed397d12d0e19

SPINE: An Initiative to Reduce Pressure Sore Recurrence

Autor: Amanda L. Brown, MD, Aladdin H. Hassanein, MD, MMSc, FACS, Keith Gabriel, MD, Brian A. Mailey, MD, FACS

Publikováno v: Plastic and Reconstructive Surgery, Global Open, Vol 10, Iss 11, p e4625 (2022)

Summary:. The recurrence rate after pressure sore reconstruction remains high. Primary inciting factors can be organized into efforts aimed at wound prevention: spasticity relief, pressure off-loading, infection and contamination prevention, nutritio

Externí odkaz: https://doaj.org/article/c0ea556d6dc043d88f5ebb4ed7960db4

Hepatocyte activity of the cholesterol sensor smoothened regulates cholesterol and bile acid homeostasis in mice

Autor: George D. Dalton, Seh-Hoon Oh, Linda Tang, Stephanie Zhang, Amanda L. Brown, Venkateshwari Varadharajan, Camelia Baleanu-Gogonea, Valentin Gogonea, Preeti Pathak, J. Mark Brown, Anna Mae Diehl

Publikováno v: iScience, Vol 24, Iss 9, Pp 103089- (2021)

Summary: Cellular cholesterol is regulated by at least two transcriptional mechanisms involving sterol-regulatory-element-binding proteins (SREBPs) and liver X receptors (LXRs). Although SREBP and LXR pathways are the predominant mechanisms that sens

Externí odkaz: https://doaj.org/article/bb55d9b8b9d44c2c84e49520c90d1dcf