Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Amanda L Woerman"'
Publikováno v:
PLoS Pathogens, Vol 20, Iss 1, p e1011920 (2024)
Externí odkaz:
https://doaj.org/article/b9efe5581d7047329edcac57ad293be3
Autor:
Sara A M Holec, Jisoo Lee, Abby Oehler, Lyn Batia, Aryanna Wiggins-Gamble, Jeffrey Lau, Felicia K Ooi, Gregory E Merz, Man Wang, Daniel A Mordes, Steven H Olson, Amanda L Woerman
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010956 (2022)
In multiple system atrophy (MSA), the α-synuclein protein misfolds into a self-templating prion conformation that spreads throughout the brain, leading to progressive neurodegeneration. While the E46K mutation in α-synuclein causes familial Parkins
Externí odkaz:
https://doaj.org/article/1cc5104ca63749ee94a0198a2fd4598b
Autor:
Amanda L Woerman, Smita Patel, Sabeen A Kazmi, Abby Oehler, Jisoo Lee, Daniel A Mordes, Steven H Olson, Stanley B Prusiner
Publikováno v:
PLoS Pathogens, Vol 16, Iss 2, p e1008222 (2020)
Multiple system atrophy (MSA), a progressive neurodegenerative disease characterized by autonomic dysfunction and motor impairment, is caused by the self-templated misfolding of the protein α-synuclein. With no treatment currently available, we soug
Externí odkaz:
https://doaj.org/article/aabf984527cd4b41bb2ce6dcbd7e2056
Publikováno v:
Acta Neuropathologica. 143:311-330
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d27e2ccb7d4066e8be91f7a9bae844b
https://doi.org/10.1007/s00401-022-02403-w
https://doi.org/10.1007/s00401-022-02403-w
Autor:
Thomas W. Smith, James P. Bouley, Daryl A. Bosco, Nils Henninger, Amanda L. Woerman, Aydan Kahriman
Publikováno v:
Acta Neuropathologica Communications, Vol 9, Iss 1, Pp 1-17 (2021)
Acta Neuropathologica Communications
Acta Neuropathologica Communications
Traumatic brain injury (TBI) constitutes one of the strongest environmental risk factors for several progressive neurodegenerative disorders of cognitive impairment and dementia that are characterized by the pathological accumulation of hyperphosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::005b099e306b2b0a09fdb4be7af11e28
https://doaj.org/article/8eba09f8fce643f2a55b7e1c2d63d45d
https://doaj.org/article/8eba09f8fce643f2a55b7e1c2d63d45d
Autor:
Sara A. M. Holec, Jisoo Lee, Abby Oehler, Felicia K. Ooi, Daniel A. Mordes, Steven H. Olson, Stanley B. Prusiner, Amanda L. Woerman
Publikováno v:
Acta neuropathologica. 144(4)
In multiple system atrophy (MSA), the protein α-synuclein misfolds into a prion conformation that self-templates and causes progressive neurodegeneration. While many point mutations in the α-synuclein gene, SNCA, have been identified as the cause o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d95041af42790fa69600526623f967c
https://pubmed.ncbi.nlm.nih.gov/36018376
https://pubmed.ncbi.nlm.nih.gov/36018376
Autor:
Sara A. M. Holec, Amanda L. Woerman
Publikováno v:
Acta Neuropathologica. 142:73-86
Synucleinopathies are a group of neurodegenerative disorders caused by the misfolding and self-templating of the protein α-synuclein, or the formation of α-synuclein prions. Each disorder differs by age of onset, presenting clinical symptoms, α-sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b62760bc869c83656ef3dd588b74bb52
https://doi.org/10.1007/s00401-020-02163-5
https://doi.org/10.1007/s00401-020-02163-5
Autor:
Jacob I. Ayers, Joanne Lee, Octovia Monteiro, Amanda L. Woerman, Ann A. Lazar, Carlo Condello, Nick A. Paras, Stanley B. Prusiner
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, vol 119, iss 6
The α-synuclein protein can adopt several different conformations that cause neurodegeneration. Different α-synuclein conformers cause at least three distinct α-synucleinopathies: multiple system atrophy (MSA), dementia with Lewy bodies (DLB), and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70bd2ca964e1d1e834337731eefd1393
https://escholarship.org/uc/item/3cf4v001
https://escholarship.org/uc/item/3cf4v001
Autor:
Amanda L. Woerman
Publikováno v:
Acta Neuropathologica. 142:1-3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1118ddf344c22bd358d1454274094d93
https://doi.org/10.1007/s00401-021-02311-5
https://doi.org/10.1007/s00401-021-02311-5
Autor:
George A. Carlson, Evan Lester, Jacob I. Ayers, Felicia K. Ooi, Stanley B. Prusiner, Robert Bowser, Nadine Bakkar, Amanda L. Woerman, Joshua Wheeler, Roy Parker
Tau aggregates contribute to neurodegenerative diseases including frontotemporal dementia and Alzheimer’s disease (AD). Although RNA promotes tau aggregation in vitro, whether tau aggregates in cells contain RNA is unknown. We demonstrate in cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7ee8482b4bcb3d3c192cddd999c7efd
https://doi.org/10.1101/2021.01.27.428450
https://doi.org/10.1101/2021.01.27.428450