Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Amanda L M, Bloom"'
Publikováno v:
mBio, Vol 14, Iss 2 (2023)
ABSTRACT In response to the host environment, the human pathogen Cryptococcus neoformans must rapidly reprogram its translatome from one which promotes growth to one which is responsive to host stress. In this study, we investigate the two events whi
Externí odkaz:
https://doaj.org/article/795a1653641f41d39b668b9fb262bf07
Autor:
Amanda L. M. Bloom, Richard M. Jin, Jay Leipheimer, Jonathan E. Bard, Donald Yergeau, Elizabeth A. Wohlfert, John C. Panepinto
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
The fungal pathogen Cryptococcus neoformans can adapt to mammalian core body temperature. Here, Bloom et al. show that Ccr4-mediated decay of ribosomal protein mRNAs is important for thermotolerance and immune evasion by promoting masking of cell wal
Externí odkaz:
https://doaj.org/article/37783490fd9b450ab6089e2c3b37ef6e
Publikováno v:
mSphere, Vol 6, Iss 1 (2021)
Cryptococcus neoformans
Externí odkaz:
https://doaj.org/article/1b0b5097750c42cabec091c09bb65e0e
Publikováno v:
mBio, Vol 10, Iss 6 (2019)
ABSTRACT Cryptococcus neoformans is one of the few environmental fungi that can survive within a mammalian host and cause disease. Although many of the factors responsible for establishing virulence have been recognized, how they are expressed in res
Externí odkaz:
https://doaj.org/article/224be18819da421399e064fbf1534a9e
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
As free living organisms, fungi are challenged with a variety of environmental insults that threaten their cellular processes. In some cases, these challenges mimic conditions present within mammals, resulting in the accidental selection of virulence
Externí odkaz:
https://doaj.org/article/e7c3ee2cfc8e420dbe1b6dd8ad952c02
Publikováno v:
mSphere, Vol 3, Iss 4 (2018)
ABSTRACT In Cryptococcus neoformans, mRNAs encoding ribosomal proteins (RP) are rapidly and specifically repressed during cellular stress, and the bulk of this repression is mediated by deadenylation-dependent mRNA decay. A motif-finding approach was
Externí odkaz:
https://doaj.org/article/16ff5085e546445da27b8661628ed90a
In response to the host environment, Cryptococcus neoformans must rapidly reprogram its translatome from one which promotes growth to one which is responsive to host temperature and oxidative stress. This reprogramming is primarily driven through the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::784bdd686caa489c970a7db005d7a77e
https://doi.org/10.1101/2022.07.26.501601
https://doi.org/10.1101/2022.07.26.501601
Publikováno v:
mBio
mBio, Vol 10, Iss 6, p e02143-19 (2019)
mBio, Vol 10, Iss 6 (2019)
mBio, Vol 10, Iss 6, p e02143-19 (2019)
mBio, Vol 10, Iss 6 (2019)
Fungal survival in a mammalian host requires the coordinated expression and downregulation of a large cohort of genes in response to cellular stresses. Initial infection with C. neoformans occurs in the lungs, where it interacts with host macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cfef3d9b8b1ee9867a0d543f40de9ff
https://doi.org/10.1128/mbio.02143-19
https://doi.org/10.1128/mbio.02143-19
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
As free living organisms, fungi are challenged with a variety of environmental insults that threaten their cellular processes. In some cases, these challenges mimic conditions present within mammals, resulting in the accidental selection of virulence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c892b573ad01bc3df132cf64a2d05743
https://doi.org/10.3389/fcimb.2019.00318
https://doi.org/10.3389/fcimb.2019.00318
Publikováno v:
Molecular Microbiology. 102:306-320
The pathogenic fungus Cryptococcus neoformans must adapt to glucose-limited conditions in the lung and glucose replete conditions upon dissemination to the brain. We report that glucose controls ribosome biogenesis and translation by modulating mRNA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d565e6abca13c61aa832b6d839735364
https://doi.org/10.1111/mmi.13461
https://doi.org/10.1111/mmi.13461