Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Amanda L Blasius"'
Publikováno v:
PLoS Pathogens, Vol 8, Iss 9, p e1002915 (2012)
Plasmacytoid dendritic cells (pDCs) are the major producers of type I IFN in response to viral infection and have been shown to direct both innate and adaptive immune responses in vitro. However, in vivo evidence for their role in viral infection is
Externí odkaz:
https://doaj.org/article/b572b0d142c942798b5146414ebbf07c
Autor:
Amanda L. Blasius, Rosana Gonzalez-Quintial, Ivo Rimann, Keiko Ozato, Bruce Beutler, Argyrios N. Theofilopoulos, Dwight H. Kono, Roberto Baccala
Publikováno v:
Proceedings of the National Academy of Sciences. 110:2940-2945
In vitro evidence suggests that plasmacytoid dendritic cells (pDCs) are intimately involved in the pathogenesis of lupus. However, it remains to be determined whether these cells are required in vivo for disease development, and whether their contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bade16b44615bafcc5b00c62b5ab626
https://doi.org/10.1073/pnas.1222798110
https://doi.org/10.1073/pnas.1222798110
Autor:
Matt J. Petrus, Ardem Patapoutian, Byung Kwan Lim, Amanda L. Blasius, José R. Criado, Yu Xia, Kirk U. Knowlton, Anna Narezkina, Cindy L. Ehlers, Derek N. Wills, Adrienne E. Dubin, Bruce Beutler, Eva Marie Y Moresco
Publikováno v:
Proceedings of the National Academy of Sciences. 108:19413-19418
The voltage-gated sodium channel Na v 1.8 is known to function in the transmission of pain signals induced by cold, heat, and mechanical stimuli. Sequence variants of human Na v 1.8 have been linked to altered cardiac conduction. We identified an all
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9fe6007d02292c5b64fdb9ca2b1b894e
https://doi.org/10.1073/pnas.1117020108
https://doi.org/10.1073/pnas.1117020108
Autor:
Xiaohong Li, Amanda L. Blasius, Pei Lin, Yu Xia, Nora G. Smart, Carrie N. Arnold, Bruce Beutler, Charles Ross, Philippe Georgel, Sophie Rutschmann
Publikováno v:
Proceedings of the National Academy of Sciences. 107:19973-19978
Despite their low frequency, plasmacytoid dendritic cells (pDCs) produce most of the type I IFN that is detectable in the blood following viral infection. The endosomal Toll-like receptors (TLRs) TLR7 and TLR9 are required for pDCs, as well as other
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5bbc95858787dbf1adf45bc5983259d
https://doi.org/10.1073/pnas.1014051107
https://doi.org/10.1073/pnas.1014051107
Autor:
Amanda L. Blasius, Eva Marie Y Moresco, Celine Eidenschenk, Daniel L. Popkin, Yu Xia, Carrie N. Arnold, Karine Crozat, Ramon Arens, Bruce Beutler, Philippe Krebs, Chris A. Benedict
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
A previously unappreciated signal necessary for dendritic cell (DC)-mediated activation of natural killer (NK) cells during viral infection was revealed by a recessiveN-ethyl-N-nitrosourea-induced mutation calledwarmflash(wmfl).Wmflhomozygotes displa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b81d57ec7e6fb746e18cf0542bf6a8a0
https://doi.org/10.1073/pnas.1005186107
https://doi.org/10.1073/pnas.1005186107
Autor:
Amanda L. Blasius, Michael B. A. Oldstone, Elina J. Zuniga, Megan J. Welch, Marco Colonna, Li Ying Liou
Publikováno v:
European Journal of Immunology. 38:3388-3394
Dendritic cells (DCs) are a highly heterogeneous population that plays a critical role in host defense. We previously demonstrated that virus infection induces bone marrow (BM) plasmacytoid (p)DCs differentiation into CD11b+ conventional (c)DCs upon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5271e2b32f474695080b25dff1e7bf9
https://doi.org/10.1002/eji.200838282
https://doi.org/10.1002/eji.200838282
Autor:
Ben A. Croker, Brian R. Lawson, Sophie Rutschmann, Michael Berger, Celine Eidenschenk, Amanda L. Blasius, Eva Marie Y. Moresco, Sosathya Sovath, Louise Cengia, Leonard D. Shultz, Argyrios N. Theofilopoulos, Sven Pettersson, Bruce Alan Beutler
Publikováno v:
Proceedings of the National Academy of Sciences. 105:15028-15033
A recessive phenotype calledspin(spontaneous inflammation) was induced byN-ethyl-N-nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic inflammatory lesions affecting the feet, salivary glands and lungs, and antichromatin antib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16e7ac0c9343c0aa09253b8cbcaf94d0
https://doi.org/10.1073/pnas.0806619105
https://doi.org/10.1073/pnas.0806619105
Publikováno v:
The Journal of Experimental Medicine
Lymphoid organs contain a B220(+)CD11c(+)NK1.1(+) cell population that was recently characterized as a novel dendritic cell (DC) subset that functionally overlaps with natural killer (NK) cells and plasmacytoid DCs (PDCs). Using Siglec-H and NK1.1 ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3705ea0cd2777fc041d2d883d599385f
https://doi.org/10.1084/jem.20070991
https://doi.org/10.1084/jem.20070991
Autor:
Bryce A. Binstadt, Margot Brickelmaier, John P. Carulli, Heloisa Sawaya, Ralph Weissleder, Christophe Benoist, Amanda L. Blasius, Diane Mathis, Leonid Gorelik, Umar Mahmood, Hsin Jung Wu
Publikováno v:
The Journal of Experimental Medicine
Unmethylated CpG-oligodeoxynucleotides (ODNs) are generally thought of as potent adjuvants with considerable therapeutic potential to enhance immune responses against microbes and tumors. Surprisingly, certain so-called stimulatory CpG-ODNs strongly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e26c94616da759e60370911f5fdc0b91
https://doi.org/10.1084/jem.20070285
https://doi.org/10.1084/jem.20070285
Publikováno v:
Cellular Immunology. 242:91-98
In this study, we sorted total bone marrow (BM) into six distinct subsets based on surface expression of CD31 and Ly6C and investigated the capacity of these subsets to acquire characteristics of plasmacytoid dendritic cells (PDCs) after in vitro cul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40144b79a63e359dd92191a432f342cd
https://doi.org/10.1016/j.cellimm.2006.09.009
https://doi.org/10.1016/j.cellimm.2006.09.009