Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amanda L Armijo"'
Autor:
Courtney Lunger, Zeli Shen, Hilda Holcombe, Anthony J. Mannion, JoAnn Dzink-Fox, Susanna Kurnick, Yan Feng, Sureshkumar Muthupalani, Sebastian E. Carrasco, Keith T. Wilson, Richard M. Peek, M. Blanca Piazuelo, Douglas R. Morgan, Amanda L. Armijo, Melissa Mammoliti, Timothy C. Wang, James G. Fox
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 1 (2024)
ABSTRACT Helicobacter pylori (H. pylori) causes a cascade from gastritis to gastric neoplasia. During the chronic stages, the oncogenic transcription factor forkhead box protein M1 (FOXM1) becomes increasingly expressed. Given certain strains of the
Externí odkaz:
https://doaj.org/article/0cc4e0cdd03c4002a30d01f014dbcd22
Autor:
Amanda L Armijo, Pennapa Thongararm, Bogdan I Fedeles, Judy Yau, Jennifer E Kay, Joshua J Corrigan, Marisa Chancharoen, Supawadee Chawanthayatham, Leona D Samson, Sebastian E Carrasco, Bevin P Engelward, James G Fox, Robert G Croy, John M Essigmann
Publikováno v:
NAR Cancer. 5
DNA-methylating environmental carcinogens such as N-nitrosodimethylamine (NDMA) and certain alkylators used in chemotherapy form O6-methylguanine (m6G) as a functionally critical intermediate. NDMA is a multi-organ carcinogen found in contaminated wa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4070f6d0bc303354aa24c64ca34ce318
https://doi.org/10.1093/narcan/zcad015
https://doi.org/10.1093/narcan/zcad015
Autor:
Lina Kim, Jeerawan Promvijit, Apinya Thiantanawat, Amanda L. Armijo, Panida Navasumrit, Robert G. Croy, Pennapa Thongararm, Sakunchai Khumsubdee, Bogdan I. Fedeles, John M. Essigmann, Mathuros Ruchirawat
Publikováno v:
Chemical Research in Toxicology. 33:625-633
DNA methylating agents are abundant in the environment and are sometimes used in cancer chemotherapy. They react with DNA to form methyl-DNA adducts and byproduct lesions that can be both toxic and...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1563f3dd17ed8b509b7c6d5edab10720
https://doi.org/10.1021/acs.chemrestox.9b00444
https://doi.org/10.1021/acs.chemrestox.9b00444
Autor:
Ishwar N. Kohale, Joshua J. Corrigan, Ilana S. Nazari, Leona D. Samson, Forest M. White, Sebastian E. Carrasco, Robert G. Croy, Dushan N. Wadduwage, Amanda L. Armijo, Jennifer E. Kay, Bevin P. Engelward, Stephen D. Dertinger, John M. Essigmann, Svetlana L. Avlasevich, Dorothea K. Torous
Publikováno v:
Cell Rep
Elsevier
Elsevier
SummaryN-nitrosodimethylamine (NDMA) is a DNA methylating agent that has been discovered to contaminate water, food and drugs. The alkyladenine glycosylase (AAG) removes methylated bases to initiate the base excision repair (BER) pathway. To understa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e142bd257cb89cb964406cf85acc6f9e
https://doi.org/10.1101/2021.01.12.426356
https://doi.org/10.1101/2021.01.12.426356
Autor:
Pennapa, Thongararm, Bogdan I, Fedeles, Sakunchai, Khumsubdee, Amanda L, Armijo, Lina, Kim, Apinya, Thiantanawat, Jeerawan, Promvijit, Panida, Navasumrit, Mathuros, Ruchirawat, Robert G, Croy, John M, Essigmann
Publikováno v:
Chemical research in toxicology. 33(2)
DNA methylating agents are abundant in the environment and are sometimes used in cancer chemotherapy. They react with DNA to form methyl-DNA adducts and byproduct lesions that can be both toxic and mutagenic. Foremost among the mutagenic lesions is O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d09f4fe8923e1bde019b5a5843b9bce
https://pubmed.ncbi.nlm.nih.gov/31841318
https://pubmed.ncbi.nlm.nih.gov/31841318
Autor:
Bogdan I. Fedeles, Supawadee Chawanthayatham, Amanda L. Armijo, Robert G. Croy, John M Essigmann
Publikováno v:
Cancer Prevention Research. 13:IA04-IA04
In a multicellular organism, somatic mutations represent a permanent record of the biochemical perturbations experienced by a cell in its local microenvironment. Akin to a perpetual recording device, with every replication, genomic DNA accumulates mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed7bab986cbb80bee140e959d80648b7
https://doi.org/10.1158/1940-6215.envcaprev19-ia04
https://doi.org/10.1158/1940-6215.envcaprev19-ia04
Autor:
Arnon Lavie, Julian Nomme, Caius G. Radu, Steven T. Olson, Amanda L. Armijo, Jennifer M. Murphy, Natasha D. Sansone, Ying Su
Publikováno v:
Acta crystallographica. Section D, Biological crystallography, vol 70, iss Pt 1
Deoxycytidine kinase (dCK) is a key enzyme in the nucleoside salvage pathway that is also required for the activation of several anticancer and antiviral nucleoside analog prodrugs. Additionally, dCK has been implicated in immune disorders and has be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0962ad62940b638fb15cfea454a62888
https://doi.org/10.1107/s1399004713025030
https://doi.org/10.1107/s1399004713025030
Publikováno v:
ChemMedChem. 6:623-627
Although recent advances in non-viral gene delivery vectors have greatly improved delivery and expression, effective tumor targeting of these vectors still poses a significant challenge for systemic cancer treatment. Tumor cells have been know to upr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6964ce3fdb6e1d46ffe68ba31f5c6f8
https://doi.org/10.1002/cmdc.201000541
https://doi.org/10.1002/cmdc.201000541
Autor:
Helen Su, Sung-Cheng Huang, Gerald Reischl, Roland Haubner, Wolfgang A. Weber, Amanda L. Armijo, Rebecca A. Dumont, Gregory Z. Ferl, Isabel J. Hildebrandt
Publikováno v:
Journal of Nuclear Medicine. 50:250-258
Radiolabeled arginine-glycine-aspartate (RGD) peptides are increasingly used in preclinical and clinical studies to assess the expression and function of the αvβ3 integrin, a cellular adhesion molecule involved in angiogenesis and tumor metastasis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::887e6065c93d0b34d34592f6d4c77f2d
https://doi.org/10.2967/jnumed.108.054049
https://doi.org/10.2967/jnumed.108.054049
Autor:
Tony Smith, Bernard D. Santarsiero, Arnon Lavie, Amanda L. Armijo, Johannes Czernin, Jue Wang, Michael E. Jung, Hien Anh Nguyen, Caius G. Radu, Thuc Le, Raymond M. Gipson, Julian Nomme, Zheng Li, Anastassia N. Alexandrova, Soumya Poddar
Publikováno v:
Journal of medicinal chemistry, vol 57, iss 22
Journal of Medicinal Chemistry
Nomme, J; Li, Z; Gipson, RM; Wang, J; Armijo, AL; Le, T; et al.(2014). Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. Journal of Medicinal Chemistry, 57(22), 9480-9494. doi: 10.1021/jm501124j. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9fv4j1bs
Journal of Medicinal Chemistry
Nomme, J; Li, Z; Gipson, RM; Wang, J; Armijo, AL; Le, T; et al.(2014). Structure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability. Journal of Medicinal Chemistry, 57(22), 9480-9494. doi: 10.1021/jm501124j. UCLA: Retrieved from: http://www.escholarship.org/uc/item/9fv4j1bs
© 2014 American Chemical Society. Recently, we have shown that small molecule dCK inhibitors in combination with pharmacological perturbations of de novo dNTP biosynthetic pathways could eliminate acute lymphoblastic leukemia cells in animal models.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ed3f11060d74e247782e3622cb5968a
https://escholarship.org/uc/item/9fv4j1bs
https://escholarship.org/uc/item/9fv4j1bs