Zobrazeno 1 - 10
of 34
pro vyhledávání: '"Amanda L, Gavin"'
Autor:
Kelli A. McCord, Chao Wang, Mirjam Anhalt, Wayne W. Poon, Amanda L. Gavin, Peng Wu, Matthew S. Macauley
Publikováno v:
ACS Central Science, Vol 10, Iss 2, Pp 315-330 (2024)
Externí odkaz:
https://doaj.org/article/7a94fae1b922456c8328a405dabcc8a6
Autor:
Amanda L. Gavin, Deli Huang, Tanya R. Blane, Therese C. Thinnes, Yusuke Murakami, Ryutaro Fukui, Kensuke Miyake, David Nemazee
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Loss of function polymorphisms of phospholipase D3 and D4 are associated with inflammatory diseases and their function is unclear. Here the authors show that PLD3/4 function as RNAses and deletion of these proteins in mice leads to accumulation of ss
Externí odkaz:
https://doaj.org/article/9f47727d2fa540ce8664019ff424400c
Autor:
Therese C. Thinnes, Tanya R. Blane, Deli Huang, Kensuke Miyake, Amanda L. Gavin, Ryutaro Fukui, David Nemazee, Yusuke Murakami
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Phospholipase D3 (PLD3) and PLD4 polymorphisms have been associated with several important inflammatory diseases. Here, we show that PLD3 and PLD4 digest ssRNA in addition to ssDNA as reported previously. Moreover, Pld3−/−Pld4−/− mice accumul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::144a63c2fb9043fa5928f3dce737dd08
http://europepmc.org/articles/PMC8497607
http://europepmc.org/articles/PMC8497607
Autor:
Meredith O'Keeffe, Rachel L. Sielski, Juan Carlos de la Torre, Patrick Skog, Armen Zeitjian, Brian R. Lawson, Deli Huang, Benjamin F. Cravatt, Kent G. Osborn, Markus Damme, David Nemazee, Therese C. Thinnes, Farnaz Kargaran, Hubertus Hochrein, Christoph Huber, Alessandro Zarpellon, Annica Mårtensson, Hayley S. Chong, John R. Teijaro, Phoebe Kimm, Amanda L. Gavin, Megan Briggs, Luc Teyton, Tanya R. Blane, Sebastian R. Schulz, Virginie Tardif, Ee Shan Pang
Publikováno v:
Nature immunology
The sensing of microbial genetic material by leukocytes often elicits beneficial pro-inflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linked the gene encoding phospholipase D3 (PLD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39a9bdbaccba333a5fbd414c0688719c
https://doi.org/10.1038/s41590-018-0179-y
https://doi.org/10.1038/s41590-018-0179-y
Autor:
David Nemazee, Dianne B. McKay, Therese C. Thinnes, Steve Gerondakis, Irina Caminschi, Raelene Grumont, Marianne M. Martinic, Amanda L. Gavin, Meredith O'Keeffe
Publikováno v:
The Journal of Immunology. 198:2649-2660
Nucleotide-binding and oligomerization domain (NOD)–like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans. Although studies have addressed the role of NOD proteins in innate immune responses, lit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10b102d63a398d5d8958d48b4e0142d9
https://doi.org/10.4049/jimmunol.1601462
https://doi.org/10.4049/jimmunol.1601462
Autor:
David Nemazee, Ryan Flynn, Bruce R. Blazar, Katelyn Paz, Amanda L. Gavin, Michael Zaiken, José A. Fernández, John H. Griffin, Xiao Xu, Ranjeet Kumar Sinha
Publikováno v:
Blood. 134(9)
Soluble thrombomodulin plasma concentrations are elevated in steroid-resistant graft-versus-host disease (GVHD), implying endothelial hypofunctioning for thrombomodulin-dependent generation of activated protein C’s (APC) anticoagulant, anti-inflamm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be00115d8c92b7721d5bc4b282858e42
https://pubmed.ncbi.nlm.nih.gov/31467078
https://pubmed.ncbi.nlm.nih.gov/31467078
The ssDNA exonucleases PLD3 and PLD4 are required to prevent lethal primary HLH-like disease in mice
Publikováno v:
The Journal of Immunology. 202:187.6-187.6
Leukocyte sensing of microbial genetic material often elicits beneficial proinflammatory cytokines, but dysregulated responses can cause severe pathogenesis. Genome-wide association studies have linked Phospholipase D3 (PLD3) to Alzheimer’s disease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5e4e66568adad2ebb5905a107e5aa3b6
https://doi.org/10.4049/jimmunol.202.supp.187.6
https://doi.org/10.4049/jimmunol.202.supp.187.6
Publikováno v:
The Journal of Immunology. 202:178.6-178.6
Genome-wide association studies have linked the gene encoding phospholipase D3 (PLD3) to Alzheimer’s disease and have linked PLD4 to rheumatoid arthritis and systemic sclerosis. PLD3 and PLD4 are endolysosomal proteins that we recently discovered a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::60f914f3ce8562c36d26ce8f5f70f9c4
https://doi.org/10.4049/jimmunol.202.supp.178.6
https://doi.org/10.4049/jimmunol.202.supp.178.6
Autor:
Marianne M, Martinic, Irina, Caminschi, Meredith, O'Keeffe, Therese C, Thinnes, Raelene, Grumont, Steve, Gerondakis, Dianne B, McKay, David, Nemazee, Amanda L, Gavin
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(7)
Nucleotide-binding and oligomerization domain (NOD)-like receptors NOD1 and NOD2 are cytosolic innate immune receptors that recognize microbial peptidoglycans. Although studies have addressed the role of NOD proteins in innate immune responses, littl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::da0c917ae359e6387ce5f76e490d63d4
https://pubmed.ncbi.nlm.nih.gov/28202617
https://pubmed.ncbi.nlm.nih.gov/28202617
Autor:
Sashi G. Kasimsetty, Alana A. Shigeoka, Andrew T. Scheinok, Dianne B. McKay, Amanda L. Gavin, Richard J. Ulevitch
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 199(3)
Nucleotide-binding oligomerization domain (Nod)–containing proteins Nod1 and Nod2 play important roles in the innate immune response to pathogenic microbes, but mounting data suggest these pattern recognition receptors might also play key roles in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f1376eca534b0d3c9ac1c4da8ae8df6
https://pubmed.ncbi.nlm.nih.gov/28652394
https://pubmed.ncbi.nlm.nih.gov/28652394