CRLF3 plays a key role in the final stage of platelet genesis and is a potential therapeutic target for thrombocythemia

Autor: Cavan Bennett, Moyra Lawrence, Jose A. Guerrero, Simon Stritt, Amie K. Waller, Yahui Yan, Richard W. Mifsud, Jose Ballester-Beltrán, Ayesha Baig, Annett Mueller, Louisa Mayer, James Warland, Christopher J. Penkett, Parsa Akbari, Thomas Moreau, Amanda L. Evans, Souradip Mookerjee, Gary J. Hoffman, Kourosh Saeb-Parsy, David J. Adams, Amber L. Couzens, Markus Bender, Wendy N. Erber, Bernhard Nieswandt, Randy J. Read, Cedric Ghevaert

Publikováno v: Blood. 139:2227-2239

The process of platelet production has so far been understood to be a 2-stage process: megakaryocyte maturation from hematopoietic stem cells followed by proplatelet formation, with each phase regulating the peripheral blood platelet count. Proplatel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75e0ff77a46b889fca56887fe7308296
https://doi.org/10.1182/blood.2021013113

IVF or ICSI for fertility preservation?

Autor: Amanda L Evans, Bhorika Aggarwal, Howard Ryan, Sarah Martins da Silva

Publikováno v: Reproduction & Fertility
Reproduction and Fertility, Vol 2, Iss 1, Pp L1-L3 (2021)

Lay summary In IVF, eggs and sperm are added together for fertilisation to occur whereas ICSI involves injecting a single sperm into each egg. ICSI is very effective where sperm count or swimming is poor (male infertility) but is slightly riskier tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9b9dbbe6818d863cc40ec9ce3e1dbb9
http://europepmc.org/articles/PMC8812449

Transfer to the clinic: refining forward programming of hPSCs to megakaryocytes for platelet production in bioreactors

Autor: Souradip Mookerjee, Amie K. Waller, Thomas Moreau, Daniel Howard, Jonathan N. Thon, Joseph E. Italiano, Moyra Lawrence, Annie K Burton, Lehmann Marcus, Cedric Ghevaert, Holly R. Foster, Amanda Dalby, Jorge Valdez, Amanda L. Evans, Momal Taimoor

Publikováno v: Blood Adv

The production of in vitro–derived platelets has great potential for transfusion medicine. Here, we build on our experience in the forward programming (FoP) of human pluripotent stem cells (hPSCs) to megakaryocytes (MKs) and address several aspects

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783281999e46c0ce285b2cc0429d5ffe
https://pubmed.ncbi.nlm.nih.gov/33843988

Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop

Autor: Louise Bisset, David Pan, Julian Braybrook, Raul Elgueta Rebolledo, Marcelo N. Rivolta, Christopher E. Goldring, Sujith Sebastian, B. Kevin Park, Angela E Thomas, Eric J. Roos, John Gardner, Bernd Schröder, Roland Leathers, Jacqueline Barry, Andrew Webster, Ludovic Vallier, Michael H Neale, Glyn Stacey, Susan J. Kimber, Peter W. Andrews, Philip Driver, Sharon Patricia Mary Crouch, Loriana Vitillo, Robin Buckle, Helen Jesson, Lyn Healy, Peter J. Coffey, David J. Williams, Anna Hows, Amit Chandra, Claire Hutchinson, Robert Thomas, Sarah Moyle, Allan Ritchie, Ivana Barbaric, Marc Turner, Trish Murray, Tammy L. Kalber, David C. Hay, Amanda L. Evans, Curtis O. Asante, Kourosh Saeb-Parsy, Patrick J. Ginty, Ian Rees

Publikováno v: Stacey, G, Andrews, P, Asante, C, Barbaric, I, Barry, J, Bisset, L, Braybrook, J, Buckle, R, Chandra, A, Coffey, P, Crouch, S, Driver, P, Evans, A, Gardner, J, Ginty, P, Goldring, C, Hay, D C, Healy, L, Hows, A, Hutchinson, C, Jesson, H, Kalber, T, Kimber, S, Leathers, R, Moyle, S, Murray, T, Neale, M, Pan, D, Park, B K, Rebolledo, R E, Rees, I, Rivolta, M N, Ritchie, A, Roos, E J, Saeb-Parsy, K, Schröder, B, Sebastien, S, Thomas, A, Thomas, R J, Turner, M, Vallier, L, Vitillo, L, Webster, A & Williams, D 2018, ' Science-based assessment of source materials for cell-based medicines : Report of a stakeholders workshop ', Regenerative Medicine, vol. 13, no. 8, pp. 935-944 . https://doi.org/10.2217/rme-2018-0120
Stacey, G, Andrews, P, Asante, C, Barbaric, I, Barry, J, Bisset, L, Braybrook, J, Buckle, R, Chandra, A, Coffey, P, Crouch, S, Driver, P, Evans, A, Gardner, J, Ginty, P, Goldring, C, Hay, D C, Healy, L, Hows, A, Hutchinson, C, Jesson, H, Kalber, T, Kimber, S, Leathers, R, Moyle, S, Murray, T, Neale, M, Pan, D, Park, B K, Rebolledo, R E, Rees, I, Rivolta, M N, Ritchie, A, Roos, E J, Saeb-parsy, K, Schröder, B, Sebastien, S, Thomas, A, Thomas, R J, Turner, M, Vallier, L, Vitillo, L, Webster, A & Williams, D 2018, ' Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop ', Regenerative medicine, vol. 13, no. 8, pp. 935-944 . https://doi.org/10.2217/rme-2018-0120
Stacey, G, Andrews, P, Asante, C, Barbaric, I, Barry, J, Bisset, L, Braybrook, J, Buckle, R, Chandra, A, Coffey, P, Crouch, S, Driver, P, Evans, A, Gardner, J, Ginty, P, Goldring, C, Hay, D C, Healy, L, Hows, A, Hutchinson, C, Jesson, H, Kalber, T, Kimber, S, Leathers, R, Moyle, S, Murray, T, Neale, M, Pan, D, Park, B K, Rebolledo, R E, Rees, I, Rivolta, M N, Ritchie, A, Roos, E J, Saeb-parsy, K, Schröder, B, Sebastien, S, Thomas, A, Thomas, R J, Turner, M, Vallier, L, Vitillo, L, Webster, A & Williams, D 2018, ' Science-based assessment of source materials for cell-based medicines: report of a stakeholders workshop ' vol. 13, no. 8, pp. 935-944 . DOI: 10.2217/rme-2018-0120
REGENERATIVE MEDICINE

Human pluripotent stem cells (hPSCs) have the potential to transform medicine. However, hurdles remain to ensure safety for such cellular products. Science-based understanding of the requirements for source materials is required as are appropriate ma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b79c4b6bba8797216087f262c7ec211d
https://doi.org/10.2217/rme-2018-0120

Antiviral signalling in human IPSC-derived neurons recapitulates neurodevelopmental disorder phenotypes

Autor: Roland Nagy, Amalie Couch, Leo W. Perfect, Amanda L. Evans, Anthony C. Vernon, Declan G. Murphy, Jack Price, Grainne M. McAlonan, Katherine Warre-Cornish, Deepak Srivastava, Eva Loth, Annett Mueller, Timothy R. Powell, Matthew J. Reid, Pooja Raval, Cedric Ghevaert, Rodrigo R.R. Duarte

Maternal immune activation increases the risk of neurodevelopmental disorders. Elevated cytokines, such as interferon-gamma (IFNγ), in offspring’s brains play a central role. IFNγ activates an antiviral cellular state, limiting viral entry and re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd07150866bd57c0a98abc38b22138e