Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Amanda K. Smolarek"'
Autor:
Jae Young So, Amanda K Smolarek, David M Salerno, Hubert Maehr, Milan Uskokovic, Fang Liu, Nanjoo Suh
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54020 (2013)
CD44, a transmembrane glycoprotein, is a major receptor for extracellular proteins involved in invasion and metastasis of human cancers. We have previously demonstrated that the novel Gemini vitamin D analog BXL0124 [1α,25-dihydroxy-20R-21(3-hydroxy
Externí odkaz:
https://doaj.org/article/d42929bed5f945ef9b789573745e8727
Autor:
Chung S. Yang, Mao-Jung Lee, Joseph Wahler, Brian A. Wall, Paul E. Thomas, Nanjoo Suh, Jae Young So, Soumyasri Das Gupta, Sudathip Sae-tan, Haixiang Yu, Amanda K. Smolarek, Kelvin Y. Soewono
Publikováno v:
Molecular Carcinogenesis. 54:916-925
Oxidative stress is known to play a key role in estrogen-induced breast cancer. This study assessed the chemopreventive activity of the naturally occurring γ-tocopherol-rich mixture of tocopherols (γ-TmT) in early stages of estrogen-induced mammary
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bf6b4984cc5a08e511aea7ad939fda2d
https://doi.org/10.1002/mc.22164
https://doi.org/10.1002/mc.22164
Autor:
Karen T. Liby, Nanjoo Suh, Amanda K. Smolarek, Joseph Wahler, Michael B. Sporn, Yong Lin, Jae Young So, Taesook Yoon, Hubert Maehr, Milan R. Uskokovic, Weichung Joe Shih
Publikováno v:
Cancer Prevention Research. 6:959-970
HER2 (or ErbB2), a member of ErbB receptor tyrosine kinases, is overexpressed in approximately 20% of human breast cancer, and the ErbB2 signaling pathway is a critical therapeutic target for ErbB2-overexpressing breast cancer. We investigated the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0df8ccc8767ee056c8cda37242b1a64a
https://doi.org/10.1158/1940-6207.capr-13-0087
https://doi.org/10.1158/1940-6207.capr-13-0087
Autor:
Chung S. Yang, Mao Jung Lee, Ah-Ng Tony Kong, Kenneth R. Reuhl, Paul E. Thomas, Tin Oo Khor, Constance Lay Lay Saw, Shiby Paul, Anne Dombrowski, Hong Jin Lee, Chung Xiou Wang, Jae Young So, Amanda K. Smolarek, Nanjoo Suh
Publikováno v:
Molecular Carcinogenesis. 52:514-525
Previous clinical and epidemiological studies of vitamin E have used primarily α-tocopherol for the prevention of cancer. However, γ-tocopherol has demonstrated greater anti-inflammatory and anti-tumor activity than α-tocopherol in several animal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::391dbcd118a3b2e6a6dc81265a751846
https://doi.org/10.1002/mc.21886
https://doi.org/10.1002/mc.21886
Autor:
Amanda K. Smolarek, Nanjoo Suh
Publikováno v:
Nutrients, Vol 3, Iss 11, Pp 962-986 (2011)
Nutrients
Nutrients
Vitamin E consists of eight different variants: α-, β-, γ-, and δ-tocopherols (saturated phytyl tail) and α-, β-, γ-, and δ-tocotrienols (unsaturated phytyl tail). Cancer prevention studies with vitamin E have primarily utilized the variant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30ce30262fadc0bab7580b8cdb943709
http://www.mdpi.com/2072-6643/3/11/962/
http://www.mdpi.com/2072-6643/3/11/962/
A Novel Gemini Vitamin D Analog Represses the Expression of a Stem Cell Marker CD44 in Breast Cancer
Autor:
Hubert Maehr, Amanda K. Smolarek, Fang Liu, Li Cai, Nanjoo Suh, Xi Zheng, Chung-Xiou Wang, Jae Young So, Hong Jin Lee, Shiby Paul, Milan R. Uskokovic, Allan H. Conney
Publikováno v:
Molecular Pharmacology. 79:360-367
CD44 is a multifunctional transmembrane protein involved in cell proliferation, angiogenesis, invasion, and metastasis. CD44 is identified as a cancer stem cell marker, and the CD44-positive breast cancer cells are enriched in residual breast cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43c58dd7541f66c761a0f0a8f963cb8c
https://doi.org/10.1124/mol.110.068403
https://doi.org/10.1124/mol.110.068403
Autor:
Jae-Young So, Milan R. Uskokovic, Andrew J. DeCastro, Amanda K. Smolarek, Hong Jin Lee, Shiby Paul, Hubert Maehr, Nanjoo Suh
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 121:408-412
Numerous synthetic vitamin D analogs have been studied for their effects on the prevention and treatment of breast cancer. However, the inhibitory effects of naturally occurring 1alpha,25-dihydroxyvitamin D3 or its synthetic analogs on ErbB2 overexpr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d2ec04328ea748ae610faa6fc68525a
https://doi.org/10.1016/j.jsbmb.2010.03.053
https://doi.org/10.1016/j.jsbmb.2010.03.053
Autor:
Andrew J. DeCastro, Barbara Simi, Shiby Paul, Hong Jin Lee, Renping Zhou, Nanjoo Suh, Jae Young So, Agnes M. Rimando, Chung Xiou Wang, Amanda K. Smolarek
Publikováno v:
Carcinogenesis. 31:1272-1278
Stilbenes are phytochemicals present in grapes, berries, peanuts and red wine. A widely studied stilbene, resveratrol (trans-3,5,4'-trihydroxystilbene), has been shown to exert antioxidant, anti-inflammatory, chemopreventive and antiaging effects in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d692c2dbafe987813ebd6224b859279e
https://doi.org/10.1093/carcin/bgq004
https://doi.org/10.1093/carcin/bgq004
Autor:
Harold L. Newmark, Nanjoo Suh, Hong Jin Lee, Jihyeung Ju, Mao-Jung Lee, Chung S. Yang, Jae-Young So, Andrew J. DeCastro, Amanda K. Smolarek, Shiby Paul
Publikováno v:
Clinical Cancer Research. 15:4242-4249
Purpose: Tocopherols are lipophilic antioxidants present in vegetable oils. Although the antioxidant and anticancer activities of α-tocopherol (vitamin E) have been studied for decades, recent intervention studies with α-tocopherol have been negati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01d005bd818679d62633a76ea6189bb1
https://doi.org/10.1158/1078-0432.ccr-08-3028
https://doi.org/10.1158/1078-0432.ccr-08-3028
Autor:
Jae Young So, Yu Kuo Chen, Ah Ng Tony Kong, Guangxun Li, Nanjoo Suh, Weichung Joe Shih, Chung S. Yang, Amanda K. Smolarek, Kenneth Reuhl, Brenda Burgess, Yong Lin, Mao Jung Lee
Publikováno v:
Cancer prevention research (Philadelphia, Pa.). 5(11)
Tocopherol, a member of the vitamin E family, consists of four forms designated as α, β, γ, and δ. Several large cancer prevention studies with α-tocopherol have reported no beneficial results, but recent laboratory studies have suggested that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6460250a9969fe9240b466f1b565f0f
https://pubmed.ncbi.nlm.nih.gov/22964476
https://pubmed.ncbi.nlm.nih.gov/22964476