Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Amanda K. P. Mann"'
Publikováno v:
Pharmaceutics, Vol 13, Iss 8, p 1307 (2021)
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid dispersions (ASD)
Externí odkaz:
https://doaj.org/article/ae501fb8400a42169cad2e01ad374382
Autor:
James D. Ormes, Grace A Okoh, Amanda K. P. Mann, Andre Hermans, Lynne S. Taylor, Ruochen Yang, Tu Van Duong
Publikováno v:
Molecular Pharmaceutics. 18:2066-2081
Dissolution of amorphous solid dispersions (ASD) can lead to the formation of amorphous drug-rich nano species (nanodroplets) via liquid-liquid phase separation or glass-liquid phase separation when the drug concentration exceeds the amorphous solubi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6d17398256ee9be00efb40271ff3b23
https://doi.org/10.1021/acs.molpharmaceut.1c00055
https://doi.org/10.1021/acs.molpharmaceut.1c00055
Publikováno v:
Pharmaceutics, Vol 13, Iss 1307, p 1307 (2021)
Pharmaceutics
Volume 13
Issue 8
Pharmaceutics
Volume 13
Issue 8
Presently, a large number of drug molecules in development are BCS class II or IV compounds with poor aqueous solubility. Various novel solubilization techniques have been used to enhance drug solubility. Among them, amorphous solid dispersions (ASD)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d887de46d9dd086c3df47a8dbfb43d72
https://www.mdpi.com/1999-4923/13/8/1307
https://www.mdpi.com/1999-4923/13/8/1307
Autor:
Aaron S. Cote, Andre Hermans, Zhen Liu, Siwei Zhang, Jie Ren, Amanda K. P. Mann, Luke Schenck, Mikolaj Milewski, Kristel Dewitt
Publikováno v:
International Journal of Pharmaceutics. 559:147-155
Amorphous solid dispersions are a promising option for managing compounds with poor aqueous solubility. However, for compounds with high melting points, thermal stability limitations, or poor solubility in volatile solvents, conventional routes of ho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0707887cd7240ace2d041b93159cac9c
https://doi.org/10.1016/j.ijpharm.2019.01.009
https://doi.org/10.1016/j.ijpharm.2019.01.009
Autor:
Michael Lowinger, James D. Litster, Lynne S. Taylor, Wei Xu, James D. Ormes, Sanjaykumar Patel, Jennifer Lu, Amanda K. P. Mann
Publikováno v:
Crystal Growth & Design. 17:3528-3537
Supersaturating formulations have become a popular approach to address the issue of inadequate aqueous solubility for small molecules. Given that prevention of nucleation may not be always possible, it is of particular interest to control crystal gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2542710b0e307acc7bd760b231779900
https://doi.org/10.1021/acs.cgd.7b00464
https://doi.org/10.1021/acs.cgd.7b00464
Autor:
James D. Litster, Lynne S. Taylor, James D. Ormes, Amanda K. P. Mann, Michael Lowinger, Wei Xu, Jennifer Lu
Publikováno v:
Crystal Growth & Design. 17:2782-2791
Currently, it is of interest to improve the oral absorption of poorly water-soluble therapeutic agents using supersaturating formulations. Understanding crystallization kinetics of supersaturated drug solutions is central to the design and evaluation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e8b11dd707cd43ba526421f21312ed08
https://doi.org/10.1021/acs.cgd.7b00237
https://doi.org/10.1021/acs.cgd.7b00237
Autor:
Banghao Chen, Edward W. Hagaman, Lance W. Gill, Steven H. Overbury, Ariana Beste, Amanda K. P. Mann, Meijun Li
Publikováno v:
The Journal of Physical Chemistry C. 121:7450-7465
1H nuclear magnetic resonance (NMR) spectroscopy was used to study hydroxylic surface species on ceria nanocubes, a crystalline, high-surface-area CeO2 that presents mostly (100) facets. Water adsorption and desorption experiments in combination with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e9a387373b7deb71bfe994369241bf9
https://doi.org/10.1021/acs.jpcc.6b12375
https://doi.org/10.1021/acs.jpcc.6b12375
Autor:
Lynne S. Taylor, Sanjaykumar Patel, James D. Litster, Michael Lowinger, Amanda K. P. Mann, Wei Xu, James D. Ormes, Jennifer Lu
Publikováno v:
CrystEngComm. 19:4797-4806
Bile salts are endogenous surfactants present in the human gastrointestinal tract in the form of mixed micelles that also contain phospholipids. Due to the inevitable encounter of oral drug formulations with bile salts, it is important to understand
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3564e34c664bb7d66bf3002b890cd7c1
https://doi.org/10.1039/c7ce01128h
https://doi.org/10.1039/c7ce01128h
Publikováno v:
The Journal of Physical Chemistry C. 119:7340-7350
In addition to their well-known redox character, the acid–base property is another interesting aspect of ceria-based catalysts. Herein, the effect of surface structure on the acid–base property of ceria was studied in detail by utilizing ceria na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4afea15700ac114adb287a8a631dd7b
https://doi.org/10.1021/acs.jpcc.5b00859
https://doi.org/10.1021/acs.jpcc.5b00859
Autor:
Luke Schenck, Xiaoling Jin, Chad Dalton, Melanie Marota, Athanas Koynov, Alfred C. F. Rumondor, Amanda K. P. Mann
Publikováno v:
Journal of pharmaceutical sciences. 107(1)
Many small-molecule active pharmaceutical ingredients (APIs) exhibit low aqueous solubility and benefit from generation of amorphous dispersions of the API and polymer to improve their dissolution properties. Spray drying and hot-melt extrusion are 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46d2f79e227a360881b63fa663ad333c
https://pubmed.ncbi.nlm.nih.gov/28711592
https://pubmed.ncbi.nlm.nih.gov/28711592