Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Amanda K. McCullough"'
Autor:
Irina G. Minko, Markus Voehler, Michael P. Stone, Andrew H. Kellum, Rachana Tomar, Amanda K. McCullough, R. Stephen Lloyd
Publikováno v:
Chemical Research in Toxicology. 34:901-911
Dietary exposure to aflatoxins is a significant risk factor in the development of hepatocellular carcinomas. Following bioactivation by microsomal P450s, the reaction of aflatoxin B1 (AFB1) with guanine (Gua) in DNA leads to the formation of stable,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fe49cb43b95cca8e66ec8c16b6e6708
https://doi.org/10.1021/acs.chemrestox.0c00517
https://doi.org/10.1021/acs.chemrestox.0c00517
Autor:
R. Stephen Lloyd, Amanda K. McCullough
Publikováno v:
DNA Repair. 77:76-86
Chronic dietary exposure to aflatoxin B(1) (AFB(1)), concomitant with hepatitis B infection is associated with a significant increased risk for hepatocellular carcinomas (HCCs) in people living in Southeast Asia and sub-Saharan Africa. Human exposure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f5263dab21e72d24426a0cb19a68b93
https://doi.org/10.1016/j.dnarep.2019.03.004
https://doi.org/10.1016/j.dnarep.2019.03.004
Autor:
Irina G. Minko, Amanda K. McCullough, Michael P. Stone, R. Stephen Lloyd, Plamen P. Christov, Liang Li
Publikováno v:
DNA Repair. 73:49-54
A variety of agents cause DNA base alkylation damage, including the known hepatocarcinogen aflatoxin B1 (AFB1) and chemotherapeutic drugs derived from nitrogen mustard (NM). The N7 site of guanine is the primary site of alkylation, with some N7-deoxy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2025d36bcdc3593c0ee89e43a22d3359
https://doi.org/10.1016/j.dnarep.2018.11.001
https://doi.org/10.1016/j.dnarep.2018.11.001
Autor:
Lloyd Rs, Rachana Tomar, Irina G. Minko, Andrew Kellum, Markus Voehler, Amanda K. McCullough, Michael P. Stone
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0d2981e5b360164c7e010b50786fdda
https://doi.org/10.1096/fasebj.2021.35.s1.05386
https://doi.org/10.1096/fasebj.2021.35.s1.05386
Autor:
Amanda K. McCullough, Samantha A. Moellmer, Sydney K. Cammann, Nichole Owen, Irina G. Minko, R. Stephen Lloyd
Publikováno v:
Proc Natl Acad Sci U S A
Human clinical trials suggest that inhibition of enzymes in the DNA base excision repair (BER) pathway, such as PARP1 and APE1, can be useful in anticancer strategies when combined with certain DNA-damaging agents or tumor-specific genetic deficienci
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e34212074084bac831889105d1187be7
https://europepmc.org/articles/PMC7980395/
https://europepmc.org/articles/PMC7980395/
Autor:
Rachana, Tomar, Irina G, Minko, Andrew H, Kellum, Markus W, Voehler, Michael P, Stone, Amanda K, McCullough, R Stephen, Lloyd
Publikováno v:
Chem Res Toxicol
Dietary exposure to aflatoxins is a significant risk factor in the development of hepatocellular carcinomas (HCCs). Following bioactivation by microsomal P450s, the reaction of aflatoxin B(1) (AFB(1)) with guanine (Gua) in DNA leads to the formation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::279479c45ef72e58e84bf58b468ebd25
https://pubmed.ncbi.nlm.nih.gov/33595290
https://pubmed.ncbi.nlm.nih.gov/33595290
Autor:
Aaron C Jacobs, Marcus J Calkins, Ajit Jadhav, Dorjbal Dorjsuren, David Maloney, Anton Simeonov, Pawel Jaruga, Miral Dizdaroglu, Amanda K McCullough, R Stephen Lloyd
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e81667 (2013)
Following the formation of oxidatively-induced DNA damage, several DNA glycosylases are required to initiate repair of the base lesions that are formed. Recently, NEIL1 and other DNA glycosylases, including OGG1 and NTH1 were identified as potential
Externí odkaz:
https://doaj.org/article/16a070dcb91f43a9948472fe00739a07
Autor:
Amanda K. McCullough, Martin Egli, Vladimir Vartanian, R. Stephen Lloyd, Jongchan Yeo, Miral Dizdaroglu, Naoto N. Tozaki, Erdem Coskun, Sanem Hosbas Coskun, Michael P. Stone, Pawel Jaruga, Irina G. Minko, Sheila S. David
Publikováno v:
DNA Repair (Amst)
Pre-mRNA encoding human NEIL1 undergoes editing by adenosine deaminase ADAR1 that converts a single adenosine to inosine, and this conversion results in an amino acid change of lysine 242 to arginine. Previous investigations of the catalytic efficien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ce12a2f9822ce2bfccbaac7c1ec4b82
https://escholarship.org/uc/item/72z2t1bq
https://escholarship.org/uc/item/72z2t1bq
Autor:
Jennifer Eng, Amanda K. McCullough, Robert G. Croy, Michael P. Stone, Michael R. Lasarev, Lauriel F. Earley, Supawadee Chawanthayatham, Irina G. Minko, Rosemary Makar, Liang Li, R. Stephen Lloyd, Ying Chih Lin, John D. Groopman, John M. Essigmann, Matthew T. Camp, Vladimir Vartanian, Patricia A. Egner
Publikováno v:
Proceedings of the National Academy of Sciences. 114:4207-4212
Global distribution of hepatocellular carcinomas (HCCs) is dominated by its incidence in developing countries, accounting for >700,000 estimated deaths per year, with dietary exposures to aflatoxin (AFB1) and subsequent DNA adduct formation being a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c020c82da52a51e57e9c4b5568de006
https://doi.org/10.1073/pnas.1620932114
https://doi.org/10.1073/pnas.1620932114
Autor:
Amanda K. McCullough, Sydney Weber Boutros, Tamily A. Weissman, Randall L. Woltjer, Colin M. Wakeham, Sydney E. Dent, Valerie R. Osterberg, Jacob Raber, Esteban Luna, Nichole Owen, Leah J. Weston, Kelvin C. Luk, Vivek K. Unni, Allison J. Schaser, Teresa L. Stackhouse
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-19 (2019)
Alpha-synuclein is a presynaptic protein that forms abnormal cytoplasmic aggregates in Lewy body disorders. Although nuclear alpha-synuclein localization has been described, its function in the nucleus is not well understood. We demonstrate that alph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c9023a05ee8cb512083e9305cb95a6
https://doi.org/10.1038/s41598-019-47227-z
https://doi.org/10.1038/s41598-019-47227-z