Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amanda J. Woodrooffe"'
Autor:
Philip R. Holland, Peter J. Goadsby, Howard J. Loraine, Amanda J. Woodrooffe, Kirk W. Johnson, Paul R. Murdock, Marta Vila-Pueyo, Keith Page
Publikováno v:
British Journal of Pharmacology. 179:358-370
BACKGROUND AND PURPOSE Lasmiditan is a novel selective 5-HT1F receptor agonist, recently approved for acute treatment of migraine. 5-HT1F receptors are widely expressed in the CNS and trigeminovascular system. Here, we have explored the therapeutic e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ceb001a11e4390b29479851cbf25d11
https://doi.org/10.1111/bph.15699
https://doi.org/10.1111/bph.15699
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 36:636-648
Purpose: JV-GL1 is an efficacious, potent, and long-acting antiglaucoma agent, according to studies in ocular normotensive and hypertensive monkeys. As an obligatory step in the drug development pr...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f903302f7828a11aa06028f871e1ceb
https://doi.org/10.1089/jop.2020.0033
https://doi.org/10.1089/jop.2020.0033
Autor:
Marta, Vila-Pueyo, Keith, Page, Paul R, Murdock, Howard J, Loraine, Amanda J, Woodrooffe, Kirk W, Johnson, Peter J, Goadsby, Philip R, Holland
Publikováno v:
British journal of pharmacologyREFERENCES. 179(3)
Lasmiditan is a novel selective 5-HTElectrical stimulation of the dura mater or the superior salivatory nucleus in anaesthetised rats evoked trigeminovascular or trigeminal-autonomic reflex activation at the level of the trigeminocervical complex. Ad
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d32de0eea2ae9f3bb2690319a6ee4d58
https://pubmed.ncbi.nlm.nih.gov/34600443
https://pubmed.ncbi.nlm.nih.gov/34600443
Autor:
Guoxian Tao, Robert A. Coleman, Carol B. Toris, Amanda J. Woodrooffe, Shan Fan, David F. Woodward, Jenny W. Wang, Kenneth L. Clark, W. Daniel Stamer
Publikováno v:
Journal of Ocular Pharmacology and Therapeutics. 35:265-277
Purpose: Two features define the future of glaucoma therapeutics: (1) greatly improved ocular hypotensive efficacy and (2) a delivery method that improves patient convenience and complianc...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67558099956415448592c4ce9b2021c6
https://doi.org/10.1089/jop.2018.0126
https://doi.org/10.1089/jop.2018.0126
Autor:
David F. Woodward, Shan Fan, Jenny W. Wang, Kenneth Lyle Clark, Amanda J. Woodrooffe, R.A. Coleman, Carol B. Toris
Publikováno v:
British Journal of Pharmacology
Background and purpose Prostanoid EP2 receptor agonists exhibit several activities including ocular hypotension, tocolysis and anti-inflammatory activity. This report describes the affinity and selectivity of a structurally novel, non-prostanoid EP2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::502f56a93235fa102de69058573ebfe4
http://europepmc.org/articles/PMC6365485
http://europepmc.org/articles/PMC6365485
Autor:
Marcel J. de Groot, Karen Maubach, Neil Victor Harris, Kenneth Lyle Clark, Andrea Taylor, Peter Lockey, Christopher Higgs, Amanda J. Woodrooffe, R.A. Coleman, Richard Jon Davis, Jon Sutton, David E. Clark
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2212-2221
In this Letter, we present the results of a hit-finding and lead optimization programme against the EP4 receptor (EP4R). In a short time period, we were able to discover five structurally diverse series of hit compounds using a combination of virtual
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::457e6d595baed8f00fee9134fa175352
https://doi.org/10.1016/j.bmcl.2014.02.068
https://doi.org/10.1016/j.bmcl.2014.02.068
Autor:
Amanda J. Woodrooffe, James C. Hewes, Richard W Morris, Brian R. Davidson, Darren Riddy, Barry Fuller
Publikováno v:
Journal of Hepatology. 45:263-270
Background/Aims Chemotherapy is increasingly used prior to resection of colorectal liver metastases, yet few studies have addressed its effect on the viability and function of hepatocytes. This study evaluated the effect of pre-operative chemotherapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f53e4c0425a6e4d575cc7e81990d2ae
https://doi.org/10.1016/j.jhep.2006.02.015
https://doi.org/10.1016/j.jhep.2006.02.015
Publikováno v:
Drug discovery today. 6(21)
The clinical success of a compound is often curtailed because of inadequate safety, pharmacokinetics or efficacy. Human tissue can be used to identify the potential shortcomings of new drugs before they undergo testing in man. This review highlights
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3abd9ced186f6e72e96ff6582f80f3ef
https://pubmed.ncbi.nlm.nih.gov/11677169
https://pubmed.ncbi.nlm.nih.gov/11677169
Autor:
Robert A. Coleman, Alec Oxford, Amanda J. Woodrooffe, Sarah Denny, Richard Anthony Borman, Andrew Sykes, Satinder Samra, Kenneth Lyle Clark, mark Eagle
Publikováno v:
Gastroenterology. 124:A569
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d00d4b92c192bdcbd53a5f7cb5c9bb91
https://doi.org/10.1016/s0016-5085(03)82881-0
https://doi.org/10.1016/s0016-5085(03)82881-0