Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Amanda J. Stock"'
Autor:
Amanda J. Stock, Pierina Gonzalez Paredes, Luciana Previato de Almeida, Stanley D. Kosanke, Srinivaas Chetlur, Hannah Budde, Paul Wakenight, Theresa A. Zwingman, Aaron B.I. Rosen, Eric J. Allenspach, Kathleen J. Millen, Jane H. Buckner, David J. Rawlings, Jacquelyn A. Gorman
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Type 1 diabetes (T1D) is an autoimmune disease in which pancreatic islet β-cells are attacked by the immune system, resulting in insulin deficiency and hyperglycemia. One of the top non-synonymous single-nucleotide polymorphisms (SNP) associated wit
Externí odkaz:
https://doaj.org/article/348e199e09ab4f3484da495fb0461ba0
Autor:
Amanda J. Stock, Ross A. McDevitt, Chandrakala Puligilla, Yajun Wang, Yongqing Zhang, Kun Wang, Chongkui Sun, Kevin G. Becker, Elin Lehrmann, William H. Wood, Yi Gong, Mohammad Aqdas, Myong-Hee Sung, Victoria Hoffmann, Chengyu Liu, Myriam Gorospe, Lea Harrington, Luigi Ferrucci, Yie Liu
Publikováno v:
PLoS Genetics, Vol 18, Iss 11 (2022)
Short telomeres induce a DNA damage response (DDR) that evokes apoptosis and senescence in human cells. An extant question is the contribution of telomere dysfunction-induced DDR to the phenotypes observed in aging and telomere biology disorders. One
Externí odkaz:
https://doaj.org/article/d8528a8a67f14965ac0dc544e360af43
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-15 (2018)
Abstract Neutrophils are the innate immune system’s first line of defense. Neutrophils play a critical role in protecting the host against infectious pathogens, resolving sterile injuries, and mediating inflammatory responses. The granules of neutr
Externí odkaz:
https://doaj.org/article/b5511f9074d24a1fa998bef1df950928
Publikováno v:
PeerJ, Vol 3, p e898 (2015)
Flowering is one of the most influential events in the life history of a plant and one of the main determinants of reproductive investment and lifetime fitness. It is also a highly complex trait controlled by dozens of genes. Understanding the select
Externí odkaz:
https://doaj.org/article/bfa1bbf7b201492abd9f0655a3b90000
Autor:
Amanda J. Stock, Saipriya Ayyar, Amogh Kashyap, Yunong Wang, Hagai Yanai, Matthew F. Starost, Mayuri Tanaka-Yano, Monica Bodogai, Chongkui Sun, Yajun Wang, Yi Gong, Chandrakala Puligilla, Evandro F. Fang, Vilhelm A. Bohr, Yie Liu, Isabel Beerman
Publikováno v:
GeroScience.
Short telomeres are a defining feature of telomere biology disorders (TBDs), including dyskeratosis congenita (DC), for which there is no effective general cure. Patients with TBDs often experience bone marrow failure. NAD, an essential metabolic coe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7e91d69fd6b4457a8caf225f50417d6
https://doi.org/10.1007/s11357-023-00752-2
https://doi.org/10.1007/s11357-023-00752-2
Autor:
Yie Liu, Amanda J Stock
Publikováno v:
Frontiers in Aging, Vol 2 (2021)
Telomeres are specialized nucleoprotein structures that form protective caps at the ends of chromosomes. Short telomeres are a hallmark of aging and a principal defining feature of short telomere syndromes, including dyskeratosis congenita (DC). Emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fafb41e80adca005f097cc221a5a7fc1
https://doi.org/10.3389/fragi.2021.785171
https://doi.org/10.3389/fragi.2021.785171
Publikováno v:
Curr Opin Genet Dev
The discovery that rare POT1 variants are associated with extremely long telomeres and increased cancer predisposition has provided a framework to revisit the relationship between telomere length and cancer development. Telomere shortening is linked
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46de19af3d84a8872846e01efb57ae36
https://europepmc.org/articles/PMC7230001/
https://europepmc.org/articles/PMC7230001/
Autor:
Amanda J. Stock, Lea Harrington, Vilhelm A. Bohr, Kun Wang, Sharon A. Savage, Tyler G Demarest, Blanche P. Alter, Yie Liu, Chongkui Sun, Beimeng Yang, Neelam Giri, Yi Gong
Publikováno v:
The EMBO Journal
Short telomeres are a principal defining feature of telomere biology disorders, such as dyskeratosis congenita (DC), for which there are no effective treatments. Here, we report that primary fibroblasts from DC patients and late generation telomerase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77105bfb1df539701109f8424ecd7eda
https://pubmed.ncbi.nlm.nih.gov/32935380
https://pubmed.ncbi.nlm.nih.gov/32935380
A DNA Damage Response-Independent Mechanism for Telomere Shortening-Elicited Age-Related Pathologies
Publikováno v:
Innovation in Aging
Telomere attrition is associated with telomeropathies and age-related pathologies. In telomeropathies, telomere uncapping induces a DNA damage response (DDR) that drives apoptosis or senescence. However, a defined mechanism by which telomere attritio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602e4c089a20d746320ad23f68a835c2
https://doi.org/10.1093/geroni/igaa057.3268
https://doi.org/10.1093/geroni/igaa057.3268
Autor:
Jonathan D. Wren, H. Anne Pereira, Glenn D. Prestwich, Virginie Sjoelund, Anne Kasus-Jacobi, Amanda J. Stock
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 9, p e0163330 (2016)
PLoS ONE, Vol 11, Iss 9, p e0163330 (2016)
We previously showed an elevated expression of the neutrophil protein, cationic antimicrobial protein of 37kDa (CAP37), in brains of patients with Alzheimer's disease (AD), suggesting that CAP37 could be involved in AD pathogenesis. The first step in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edad1b3478a207bf9579497d2e71eb94
http://europepmc.org/articles/PMC5038948
http://europepmc.org/articles/PMC5038948