Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Amanda J. Phipps-Green"'
Autor:
Kazi Mirajul Hoque, Eryn E. Dixon, Raychel M. Lewis, Jordyn Allan, Gregory D. Gamble, Amanda J. Phipps-Green, Victoria L. Halperin Kuhns, Anne M. Horne, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth, Owen M. Woodward
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
The common ABCG2 variant Q141K contributes to hyperuricemia and gout risk. Here, using a human interventional study and a new orthologous mouse model, the authors report a tissue specific pathobiology of the Q141K variant, and support a significant r
Externí odkaz:
https://doaj.org/article/12c73f6333324432b9f2c84850631506
Autor:
Rebekah Wrigley, Amanda J. Phipps-Green, Ruth K. Topless, Tanya J. Major, Murray Cadzow, Philip Riches, Anne-Kathrin Tausche, Matthijs Janssen, Leo A. B. Joosten, Tim L. Jansen, Alexander So, Jennie Harré Hindmarsh, Lisa K. Stamp, Nicola Dalbeth, Tony R. Merriman
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-10 (2020)
Abstract Background The ABCG2 Q141K (rs2231142) and rs10011796 variants associate with hyperuricaemia (HU). The effect size of ABCG2 rs2231142 on urate is ~ 60% that of SLC2A9, yet the effect size on gout is greater. We tested the hypothesis that ABC
Externí odkaz:
https://doaj.org/article/88e69affacaf42ba8bbee5b52156c6c7
Autor:
Nicholas A. Sumpter, Riku Takei, Murray Cadzow, Ruth K. G. Topless, Amanda J. Phipps‐Green, Rinki Murphy, Janak de Zoysa, Huti Watson, Muhammad Qasim, Alexa S. Lupi, Abhishek Abhishek, Mariano Andrés, Tania O. Crișan, Michael Doherty, Lennart Jacobsson, Matthijs Janssen, Tim L. Jansen, Leo A. B. Joosten, Meliha Kapetanovic, Frédéric Lioté, Hirotaka Matsuo, Geraldine M. McCarthy, Fernando Perez‐Ruiz, Philip Riches, Pascal Richette, Edward Roddy, Blanka Stiburkova, Alexander So, Anne‐Kathrin Tausche, Rosa J. Torres, Till Uhlig, Tanya J. Major, Lisa K. Stamp, Nicola Dalbeth, Hyon K. Choi, Ana I. Vazquez, Megan P. Leask, Richard J. Reynolds, Tony R. Merriman
Publikováno v:
Arthritis & Rheumatology, 75, 816-825
Arthritis & Rheumatology, 75, 5, pp. 816-825
Arthritis & Rheumatology, 75, 5, pp. 816-825
Item does not contain fulltext OBJECTIVE: To determine whether a gout polygenic risk score (PRS) is associated with age at gout onset and tophaceous disease in European, East Polynesian, and West Polynesian men and women with gout. METHODS: A 19-vari
Autor:
Tamlin S. Conner, Karma G. McFarlane, Maria Choukri, Benjamin C. Riordan, Jayde A. M. Flett, Amanda J. Phipps-Green, Ruth K. Topless, Marilyn E. Merriman, Tony R. Merriman
Publikováno v:
Frontiers in Psychology, Vol 9 (2018)
Background: To understand the genetic underpinnings of emotion, researchers have studied genetic variants in the oxytocin system, a hormone and neurotransmitter important to socio-emotional functioning. The oxytocin receptor gene (OXTR) variant rs535
Externí odkaz:
https://doaj.org/article/9400e3bd80bb42409c870039fc4adf9f
Autor:
Natalia Smith‐Diaz, Sophie L. Stocker, Lisa K. Stamp, Nicola Dalbeth, Amanda J. Phipps‐Green, Tony R. Merriman, Daniel F. B. Wright
Publikováno v:
British Journal of Clinical Pharmacology.
This study aimed to develop and evaluate an allopurinol adherence tool based on steady-state oxypurinol plasma concentrations, allopurinol's active metabolite.Plasma oxypurinol concentrations were simulated stochastically from an oxypurinol pharmacok
Autor:
Kazi Mirajul, Hoque, Eryn E, Dixon, Raychel M, Lewis, Jordyn, Allan, Gregory D, Gamble, Amanda J, Phipps-Green, Victoria L, Halperin Kuhns, Anne M, Horne, Lisa K, Stamp, Tony R, Merriman, Nicola, Dalbeth, Owen M, Woodward
Publikováno v:
Nature communications. 11(1)
The pathophysiological nature of the common ABCG2 gout and hyperuricemia associated variant Q141K (rs2231142) remains undefined. Here, we use a human interventional cohort study (ACTRN12615001302549) to understand the physiological role of ABCG2 and
Autor:
Daniel F B, Wright, Nicola, Dalbeth, Amanda J, Phipps-Green, Tony R, Merriman, Murray L, Barclay, Jill, Drake, Paul, Tan, Anne, Horne, Lisa K, Stamp
Publikováno v:
British journal of clinical pharmacology. 84(5)
AIM: This research aims to evaluate the predictive performance of a published allopurinol dosing tool. METHODS: Allopurinol dose predictions were compared to the actual dose required to achieve serum urate (SU) T) had an important impact on the dose
Autor:
Smith‐Diaz, Natalia, Stocker, Sophie L., Stamp, Lisa K., Dalbeth, Nicola, Phipps‐Green, Amanda J., Merriman, Tony R., Wright, Daniel F. B.
Publikováno v:
British Journal of Clinical Pharmacology; Jul2023, Vol. 89 Issue 7, p1956-1964, 9p
Autor:
Sumpter, Nicholas A., Takei, Riku, Cadzow, Murray, Topless, Ruth K. G., Phipps‐Green, Amanda J., Murphy, Rinki, de Zoysa, Janak, Watson, Huti, Qasim, Muhammad, Lupi, Alexa S., Abhishek, Abhishek, Andrés, Mariano, Crișan, Tania O., Doherty, Michael, Jacobsson, Lennart, Janssen, Matthijs, Jansen, Tim L., Joosten, Leo A. B., Kapetanovic, Meliha, Lioté, Frédéric
Publikováno v:
Arthritis & Rheumatology; May2023, Vol. 75 Issue 5, p816-825, 10p
Autor:
Hoque, Kazi Mirajul, Dixon, Eryn E., Lewis, Raychel M., Allan, Jordyn, Gamble, Gregory D., Phipps-Green, Amanda J., Halperin Kuhns, Victoria L., Horne, Anne M., Stamp, Lisa K., Merriman, Tony R., Dalbeth, Nicola, Woodward, Owen M.
Publikováno v:
Nature Communications; 6/2/2020, Vol. 11 Issue 1, p1-15, 15p