Zobrazeno 1 - 10
of 72
pro vyhledávání: '"Amanda J. Law"'
PI3Kinase-p110δ Overexpression Impairs Dendritic Morphogenesis and Increases Dendritic Spine Density
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 13 (2020)
Activity and expression of the phosphoinositide 3-kinase (PI3K) catalytic isoform, PIK3CD/p110δ, is increased in schizophrenia, autism, and intellectual delay and pro-cognitive preclinical efficacy of p110δ-inhibition has been demonstrated in pharm
Externí odkaz:
https://doaj.org/article/66ecc87551974d67910a88ce2dc20663
Autor:
M. Camille Hoffman, Alena Clark, Aquila Roberts, Robert Freedman, Amanda J. Law, Sharon K. Hunter
Publikováno v:
Schizophrenia Research. 247:16-25
Choline, folic acid, and Vitamin D are essential for fetal brain development that may be the first steps in the pathogenesis of the psychotic spectrum. Micronutrient deficiencies have been associated with changes in fetal brain development, manifest
Autor:
Maria C, Hoffman, Sharon J, Hunter, Angelo, D'Alessandro, Uwe, Christians, Amanda J, Law, Robert, Freedman
Publikováno v:
American Journal of Perinatology.
Objective Small for gestational age (SGA) infants are at increased risk for neonatal morbidity and developmental problems in childhood. No current interventions during human pregnancy address this problem. This study investigated the possible relatio
Publikováno v:
Clin Nutr ESPEN
Summary Background & aims Maternal gestational infection is a well-characterized risk factor for offsprings’ development of mental disorders including schizophrenia, autism, and attention deficit disorder. The inflammatory response elicited by the
Autor:
Amanda J. Law, Sharon K. Hunter, Anna Wyrwa, Robert Freedman, Kathleen Noonan, Uwe Christians, M. Camille Hoffman
Publikováno v:
Biol Psychiatry Cogn Neurosci Neuroimaging
Background Prenatal depression has lasting effects on development in offspring, including later mental illness risk. Maternal responses to depression include inflammation and hypothalamic-pituitary-adrenal axis stimulation. Effects on development of
Autor:
Kathleen Noonan, Robert Freedman, M. Camille Hoffman, Amanda J. Law, Sharon K. Hunter, Angelo D'Alessandro, Uwe Christians, Etheldreda Nakimuli-Mpungu, Steven H. Zeisel, Lizbeth McCarthy, Anna Wyrwa
Publikováno v:
Schizophr Bull
Black Americans have increased risk for schizophrenia and other mental illnesses with prenatal origins. Prenatal choline promotes infant brain development and behavioral outcomes, but choline has not been specifically assessed in Black Americans. Pre
Autor:
Kristy R. Howell, Amanda J. Law
Publikováno v:
Schizophr Res
Normative brain development is contingent on the complex interplay between genes and environment. Schizophrenia (SCZ) is considered a highly polygenic, neurodevelopmental disorder associated with impaired neural circuit development, neurocognitive fu
Autor:
Amanda J. Law, Sharon K. Hunter, M. Camille Hoffman, Anna Wyrwa, Robert Freedman, Kathleen Noonan, Angelo D'Alessandro
Publikováno v:
Psychol Med
BackgroundMaternal inflammation in early pregnancy has been identified epidemiologically as a prenatal pathogenic factor for the offspring's later mental illness. Early newborn manifestations of the effects of maternal inflammation on human fetal bra
Autor:
M. Camille Hoffman, Amanda J. Law, Jacob B. Holzman, Sharon K. Hunter, Zachary Johnson, Uwe Christians, Robert Freedman
Publikováno v:
Neuroreport
Objective Maternal depression during gestation is an adverse factor in fetal brain development that manifests in later childhood behavioral problems. Fetal heart rate variability (FHRV) mediated by parasympathetic input is a marker of gestational ner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4970b0e5c3226ef85d2148cb73065f94
https://europepmc.org/articles/PMC9762166/
https://europepmc.org/articles/PMC9762166/
Autor:
Sharon K. Hunter, Angelo D'Alessandro, Madeline Balser, Amanda J. Law, Victoria K. Walker, Robert Freedman, Kathleen Noonan, M. Camille Hoffman
Publikováno v:
J Psychiatr Res
Maternal gestational inflammation from infection, obesity, depression, and adverse childhood experiences negatively affects offspring cognitive development. Choline is a key nutrient in fetal brain development. We investigated whether higher maternal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec74bb1a914640f9d3161a67003b730f
https://europepmc.org/articles/PMC8364874/
https://europepmc.org/articles/PMC8364874/