Výsledky vyhledávání - "Amanda J. Goddard"

Mechanism of inhibition of DNA (cytosine C5)-methyltransferases by oligodeoxyribonucleotides containing 5,6-dihydro-5-azacytosine 1 1Edited by R. Huber

Autor: Janice R. Sufrin, Estela Alvarez, Canio J. Marasco, Victor E. Marquez, Xiaodong Cheng, Adam S. Brank, Margaret O'Gara, Harry Ford, Judith K. Christman, Amanda J. Goddard, Gholamreza Sheikhnejad

Publikováno v: Journal of Molecular Biology. 285:2021-2034

A key step in the predicted mechanism of enzymatic transfer of methyl groups from S-adenosyl- l -methionine (AdoMet) to cytosine residues in DNA is the transient formation of a dihydrocytosine intermediate covalently linked to cysteine in the active

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4829e75f565ddb91ce3ae3f0c2544cb5
https://doi.org/10.1006/jmbi.1998.2426

Zobrazit plný text záznamu

Synthesis of Oligonucleotides Containing 5,6-Dihydro-5-Azacytosine and 5-Azacytosine at Specific CpG Sites

Autor: Amanda J. Goddard, Victor E. Marquez

Publikováno v: Nucleosides, Nucleotides and Nucleic Acids. 8:1015-1018

The quantitative conversion of dihydro-5-azacytosine (5-DHAC) to 5-azacytosine (5-AC) has been accomplished in a dihydro-5-azacyti-dine/thymidine dimer (5-DHACpT). This newly developed procedure allows simi1ar possibilities with longer, 5-DHAC-modifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a24f77b8c879b73742a6dc1bf54d2552
https://doi.org/10.1080/07328318908054266

Zobrazit plný text záznamu

Synthesis of a phosphoramidite of 2′-deoxy-5,6-dihydro-5-azacytidine. Its potential application in the synthesis of DNA containing dihydro-5-aza-and 5-azacytosine bases

Autor: Victor E. Marquez, Amanda J. Goddard

Publikováno v: Tetrahedron Letters. 29:1767-1770

A novel phosphoramidite ( 9 ) has been synthesized and shown to be an efficient coupling reagent for the synthesis of oligonucleotide fragments containing the modified base 5,6-dihydro-5-azacytosine. With a model dihydro-5-azacytosine/thymine dimer (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d21ee567edc50963f9008d487d8af655
https://doi.org/10.1016/s0040-4039(00)82037-7

Zobrazit plný text záznamu

ChemInform Abstract: Synthesis of a Phosphoramidite of 2′-Deoxy-5,6-dihydro-5-azacytidine. Its Potential Application in the Synthesis of DNA Containing Dihydro-5-aza- and 5-Azacytosine Bases

Autor: Victor E. Marquez, Amanda J. Goddard

Publikováno v: ChemInform. 19

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7a97ec75737df794a6bacc110eab5200
https://doi.org/10.1002/chin.198836339

Zobrazit plný text záznamu

Vyhledávací nástroje:

Upřesnit hledání