Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Amanda J. Drake"'
Autor:
Eamon Fitzgerald, Matthew C. Sinton, Sara Wernig-Zorc, Nicholas M. Morton, Megan C. Holmes, James P. Boardman, Amanda J. Drake
Publikováno v:
Epigenetics & Chromatin, Vol 14, Iss 1, Pp 1-14 (2021)
Abstract Exposure to early life stress (ELS) during childhood or prenatally increases the risk of future psychiatric disorders. The effect of stress exposure during the neonatal period is less well understood. In preterm infants, exposure to invasive
Externí odkaz:
https://doaj.org/article/cb3142eba354467ea306666611a1314b
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Neonatal encephalopathy due to hypoxia–ischemia is associated with adverse neurodevelopmental effects. The involvement of branched chain amino acids (BCAAs) in this is largely unexplored. Transport of BCAAs at the plasma membrane is facili
Externí odkaz:
https://doaj.org/article/3468e047d556460a935e34e261f96c11
Combined effects of genotype and childhood adversity shape variability of DNA methylation across age
Autor:
Darina Czamara, Elleke Tissink, Johanna Tuhkanen, Jade Martins, Yvonne Awaloff, Amanda J. Drake, Batbayar Khulan, Aarno Palotie, Sibylle M. Winter, Charles B. Nemeroff, W. Edward Craighead, Boadie W. Dunlop, Helen S. Mayberg, Becky Kinkead, Sanjay J. Mathew, Dan V. Iosifescu, Thomas C. Neylan, Christine M. Heim, Jari Lahti, Johan G. Eriksson, Katri Räikkönen, Kerry J. Ressler, Nadine Provençal, Elisabeth B. Binder
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Lasting effects of adversity, such as exposure to childhood adversity (CA) on disease risk, may be embedded via epigenetic mechanisms but findings from human studies investigating the main effects of such exposure on epigenetic measures, inc
Externí odkaz:
https://doaj.org/article/4c6b5ab8f5034902862fa2eca59f3b06
Autor:
Karla J. Suchacki, Adriana A. S. Tavares, Domenico Mattiucci, Erica L. Scheller, Giorgos Papanastasiou, Calum Gray, Matthew C. Sinton, Lynne E. Ramage, Wendy A. McDougald, Andrea Lovdel, Richard J. Sulston, Benjamin J. Thomas, Bonnie M. Nicholson, Amanda J. Drake, Carlos J. Alcaide-Corral, Diana Said, Antonella Poloni, Saverio Cinti, Gavin J. Macpherson, Marc R. Dweck, Jack P. M. Andrews, Michelle C. Williams, Robert J. Wallace, Edwin J. R. van Beek, Ormond A. MacDougald, Nicholas M. Morton, Roland H. Stimson, William P. Cawthorn
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Bone marrow adipose tissue (BMAT) comprises over 10% of total fat mass but its systemic metabolic role is unclear. Here, the authors show that BMAT glucose uptake is not insulin or cold responsive; however, BMAT basal glucose uptake is higher than in
Externí odkaz:
https://doaj.org/article/1d8037faca4e43bfbbf32bcfca139cb8
Autor:
Marcus J. Lyall, John P. Thomson, Jessy Cartier, Raffaele Ottaviano, Timothy J. Kendall, Richard R. Meehan, Amanda J. Drake
Publikováno v:
Epigenetics, Vol 15, Iss 1-2, Pp 61-71 (2020)
Non-alcoholic fatty liver disease (NAFLD) is now the commonest cause of liver disease in developed countries affecting 25–33% of the general population and up to 75% of those with obesity. Recent data suggest that alterations in DNA methylation may
Externí odkaz:
https://doaj.org/article/0306e657ff6a4edc950dc78da79355a9
Autor:
Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Amanda J. Drake, David C. Hay
Publikováno v:
STAR Protocols, Vol 2, Iss 2, Pp 100493- (2021)
Summary: This protocol describes the production of hepatocyte-like cells (HLCs) from human pluripotent stem cells and how to induce hepatic steatosis, a condition characterized by intracellular lipid accumulation. Following differentiation to an HLC
Externí odkaz:
https://doaj.org/article/8d13b0dc3bd7402bb841e0635d89763b
Early life stress and LPS interact to modify the mouse cortical transcriptome in the neonatal period
Publikováno v:
Brain, Behavior, & Immunity - Health, Vol 13, Iss , Pp 100219- (2021)
Introduction: Preterm birth (PTB) is closely associated with atypical cerebral cortical development and cognitive impairment. Early exposure to extrauterine life often results in atypical environmental and biological experiences that co-occur, includ
Externí odkaz:
https://doaj.org/article/3caf385380ab4a1da936432e8c5e1a99
Autor:
Matthew C. Sinton, Jose Meseguer-Ripolles, Baltasar Lucendo-Villarin, Sara Wernig-Zorc, John P. Thomson, Roderick N. Carter, Marcus J. Lyall, Paul D. Walker, Alpesh Thakker, Richard R. Meehan, Gareth G. Lavery, Nicholas M. Morton, Christian Ludwig, Daniel A. Tennant, David C. Hay, Amanda J. Drake
Publikováno v:
iScience, Vol 24, Iss 1, Pp 101931- (2021)
Summary: Nonalcoholic fatty liver disease (NAFLD) is currently the most prevalent form of liver disease worldwide. This term encompasses a spectrum of pathologies, from benign hepatic steatosis to non-alcoholic steatohepatitis, which have, to date, b
Externí odkaz:
https://doaj.org/article/231ee5e1aa334f8c91d6ea963c63a1fc
Autor:
Jessy Cartier, Thomas Smith, John P. Thomson, Catherine M. Rose, Batbayar Khulan, Andreas Heger, Richard R. Meehan, Amanda J. Drake
Publikováno v:
Genome Biology, Vol 19, Iss 1, Pp 1-15 (2018)
Abstract Background Early life exposure to adverse environments affects cardiovascular and metabolic systems in the offspring. These programmed effects are transmissible to a second generation through both male and female lines, suggesting germline t
Externí odkaz:
https://doaj.org/article/6c306276f54543a09f131f709ef97c90
Autor:
Chinthika Piyasena, Jessy Cartier, Nadine Provencal, Tobias Wiechmann, Batbayar Khulan, Raju Sunderesan, Gopi Menon, Jonathan Seckl, Rebecca M. Reynolds, Elisabeth B. Binder, Amanda J. Drake
Publikováno v:
Frontiers in Endocrinology, Vol 9 (2018)
Externí odkaz:
https://doaj.org/article/e60840c94c5c4122ab743d2950a527ce