Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Amanda J Tweed"'
Autor:
Megan M. Weivoda, Chee Kian Chew, David G. Monroe, Joshua N. Farr, Elizabeth J. Atkinson, Jennifer R. Geske, Brittany Eckhardt, Brianne Thicke, Ming Ruan, Amanda J. Tweed, Louise K. McCready, Robert A. Rizza, Aleksey Matveyenko, Moustapha Kassem, Thomas Levin Andersen, Adrian Vella, Matthew T. Drake, Bart L. Clarke, Merry Jo Oursler, Sundeep Khosla
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Anti-resorptive bone therapies also inhibit bone formation, as osteoclasts secrete factors that stimulate bone formation by osteoblasts. Here, the authors identify osteoclast-secreted factors that couple bone resorption to bone formation in healthy s
Externí odkaz:
https://doaj.org/article/801d47b97fd94e109d4d6b51b08d8de3
Autor:
Matthew T. Drake, Jolaine M. Hines, Joshua N. Farr, Ravinder J. Singh, Katherine L O'Grady, Amanda J Tweed, Olga P. Bondar, Brittany A. Eckhardt, Brianne S Thicke, Sara J. Achenbach, Tammie L Volkman, Sundeep Khosla, Elizabeth J. Atkinson
Publikováno v:
J Appl Lab Med
BackgroundAdvanced glycation end products (AGEs) are formed via the nonenzymatic glycation of sugars with amino acids. Two AGEs, Nε-(1-carboxymethyl)-L-Lysine (CML) and pentosidine, have been observed to be elevated in subjects suffering from a mult
Autor:
Amanda J Tweed, Joshua N. Farr, Sara J. Achenbach, Paul W. Wennberg, Jad G Sfeir, Elizabeth J. Atkinson, Parinya Samakkarnthai, Adrian Vella, Peter J. Dyck, Matthew T. Drake, Tammie L Volkman, Sundeep Khosla, Shreyasee Amin
Publikováno v:
J Clin Endocrinol Metab
Context Reduced bone material strength index (BMSi) and increased cortical porosity (CtPo) have emerged as potentially contributing to fracture risk in type 2 diabetes mellitus (T2DM) patients. Objective To determine whether BMSi or CtPo are related
Autor:
Matthew T. Drake, Sara J. Achenbach, Peter J. Dyck, Paul W. Wennberg, Jad G Sfeir, Elizabeth J. Atkinson, Amanda J Tweed, Tammie L Volkman, Sundeep Khosla, Joshua N. Farr, Parinya Samakkarnthai
Publikováno v:
Journal of the Endocrine Society
Patients with Type 2 Diabetes (T2D) are at higher fracture risk despite having relatively normal or even increased BMD by DXA. Increased cortical porosity has emerged as a potential factor contributing to fragility fractures in T2D. However, there is
Autor:
Jad G Sfeir, Sara J. Achenbach, Elizabeth J. Atkinson, Tammie L Volkman, Sundeep Khosla, Amanda J Tweed, Parinya Samakkarnthai, Matthew T. Drake, Joshua N. Farr
Publikováno v:
Journal of the Endocrine Society
Patients with Type 2 Diabetes (T2D) are at increased fracture risk despite having relatively normal or even increased BMD by DXA. The critical aspect of bone quality deterioration in T2D patients could explain this clinically important discrepancy. M
Autor:
Amanda J Tweed, Shreyasee Amin, Lifeng Yu, Sara J. Achenbach, Elizabeth J. Atkinson, Jad G Sfeir, Jon J. Camp, Sundeep Khosla, Matthew T. Drake, Louise K. McCready, Mark C. Adkins
Publikováno v:
Bone. 112:145-152
Central quantitative computed tomography (QCT) is increasingly used in clinical trials and practice to assess bone mass or strength and to evaluate longitudinal changes in response to drug treatment. Current studies utilize single-energy (SE) QCT sca
Autor:
Brianne S Thicke, Ming Ruan, Aleksey V. Matveyenko, Jennifer R. Geske, Merry Jo Oursler, Amanda J Tweed, David G. Monroe, Bart L. Clarke, Brittany A. Eckhardt, Thomas Levin Andersen, Joshua N. Farr, Chee Kian Chew, Matthew T. Drake, Sundeep Khosla, Adrian Vella, Robert A. Rizza, Elizabeth J. Atkinson, Moustapha Kassem, Louise K. McCready, Megan M. Weivoda
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Weivoda, M M, Chew, C K, Monroe, D G, Farr, J N, Atkinson, E J, Geske, J R, Eckhardt, B, Thicke, B, Ruan, M, Tweed, A J, McCready, L K, Rizza, R A, Matveyenko, A, Kassem, M, Andersen, T L, Vella, A, Drake, M T, Clarke, B L, Oursler, M J & Khosla, S 2020, ' Identification of osteoclast-osteoblast coupling factors in humans reveals links between bone and energy metabolism ', Nature Communications, vol. 11, 87 . https://doi.org/10.1038/s41467-019-14003-6
Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors. Here we utilize osteoclast ablation by denosumab (DMAb) and RNA-sequencing of bone biopsie