Zobrazeno 1 - 10
of 194
pro vyhledávání: '"Amanda J Roberts"'
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 2, p e1009800 (2022)
Alcohol Use Disorder (AUD) is a chronic, relapsing syndrome diagnosed by a heterogeneous set of behavioral signs and symptoms. There are no laboratory tests that provide direct objective evidence for diagnosis. Microarray and RNA-Seq technologies ena
Externí odkaz:
https://doaj.org/article/79541000470a41a0b3d983189d6ebe24
Autor:
Kayla Frank, Shawn Abeynaike, Rana Nikzad, Reesha R Patel, Amanda J Roberts, Marisa Roberto, Silke Paust
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0239246 (2020)
Alcohol use disorder (AUD) is a chronic relapsing disorder characterized by an impaired ability to stop or control alcohol use despite adverse social, occupational, or health consequences. AUD is associated with a variety of physiological changes and
Externí odkaz:
https://doaj.org/article/027867307a9943d297ade7d8b899f42f
Autor:
Ariadna Amador, Salvador Huitron-Resendiz, Amanda J Roberts, Theodore M Kamenecka, Laura A Solt, Thomas P Burris
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0162452 (2016)
The circadian clock maintains appropriate timing for a wide range of behaviors and physiological processes. Circadian behaviors such as sleep and wakefulness are intrinsically dependent on the precise oscillation of the endogenous molecular machinery
Externí odkaz:
https://doaj.org/article/27f1fb691c88404587ad4b777e20bbab
Interleukin-1 Interacts with Ethanol Effects on GABAergic Transmission in the Mouse Central Amygdala
Autor:
Michal eBajo, Florence P Varodayan, Samuel G Madamba, Amanda J Roberts, Lindsey M Casal, Christopher eOleata, George Robert Siggins, Marisa eRoberto
Publikováno v:
Frontiers in Pharmacology, Vol 6 (2015)
Neuroinflammation is hypothesized to enhance alcohol consumption and contribute to the development of alcoholism. GABAergic transmission in the central amygdala (CeA) plays an important role in the transition to alcohol dependence. Therefore, we stud
Externí odkaz:
https://doaj.org/article/c62e54bfb53e49a7886ef7915d79fce8
Autor:
Sheketha R. Hauser, Peter B. Hedlund, Amanda J Roberts, Youssef eSari, Richard L. Bell, Eric A. Engleman
Publikováno v:
Frontiers in Neuroscience, Vol 8 (2015)
Alcohol and drug abuse take a large toll on society and affected individuals. However, very few effective treatments are currently available to treat alcohol and drug addiction. Basic and clinical research has begun to provide some insights into the
Externí odkaz:
https://doaj.org/article/9dac294fd1b04a59806123add388728d
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e63942 (2013)
The role of brain corticotropin-releasing factor type 2 (CRF2) receptors in behavioral stress responses remains controversial. Conflicting findings suggest pro-stress, anti-stress or no effects of impeding CRF2 signaling. Previous studies have used a
Externí odkaz:
https://doaj.org/article/cca0bac2122b4ee8af9da47e19713678
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e82656 (2013)
Alcohol abuse causes dramatic neuroadaptations in the brain, which contribute to tolerance, dependence, and behavioral modifications. Previous proteomic studies in human alcoholics and animal models have identified candidate alcoholism-related protei
Externí odkaz:
https://doaj.org/article/a7ea7bdd82604928951123fa2079c1c4
Autor:
Laura L Dugan, Sameh S Ali, Grigoriy Shekhtman, Amanda J Roberts, Jacinta Lucero, Kevin L Quick, M Margarita Behrens
Publikováno v:
PLoS ONE, Vol 4, Iss 5, p e5518 (2009)
BACKGROUND:Multiple studies have shown that plasma levels of the pro-inflammatory cytokine interleukin-6 (IL-6) are elevated in patients with important and prevalent adverse health conditions, including atherosclerosis, diabetes, obesity, obstructive
Externí odkaz:
https://doaj.org/article/d8ae3ad7173140d49ddf468a74182ed5
Autor:
Reesha R. Patel, Pauravi Gandhi, Kathryn Spencer, Nihal A. Salem, Chloe. M. Erikson, Vittoria Borgonetti, Roman Vlkolinsky, Larry Rodriguez, Tali Nadav, Michal Bajo, Amanda J. Roberts, R. Dayne Mayfield, Marisa Roberto
Publikováno v:
Neurobiology of Stress, Vol 31, Iss , Pp 100657- (2024)
Chronic ethanol dependence and withdrawal activate corticotropin releasing factor (CRF)-containing GABAergic neurons in the medial prefrontal cortex (mPFC), which tightly regulate glutamatergic pyramidal neurons. Using male CRF1:GFP reporter mice, we
Externí odkaz:
https://doaj.org/article/d2231a05ef614ae7b4944802b1177bc2
Autor:
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Publikováno v:
Neurobiology of Disease, Vol 190, Iss , Pp 106361- (2024)
The prefrontal cortex is a crucial regulator of alcohol drinking, and dependence, and other behavioral phenotypes associated with AUD. Comprehensive identification of cell-type specific transcriptomic changes in alcohol dependence will improve our un
Externí odkaz:
https://doaj.org/article/ea029caacbce4f35a16a4a7a7a537be9