Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Amanda J Redig"'
Autor:
Elsa Beyer Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Publikováno v:
eLife, Vol 6 (2017)
Externí odkaz:
https://doaj.org/article/97e06b1cb72c431b99c9fe722c7f8112
Autor:
Elsa B Krall, Belinda Wang, Diana M Munoz, Nina Ilic, Srivatsan Raghavan, Matthew J Niederst, Kristine Yu, David A Ruddy, Andrew J Aguirre, Jong Wook Kim, Amanda J Redig, Justin F Gainor, Juliet A Williams, John M Asara, John G Doench, Pasi A Janne, Alice T Shaw, Robert E McDonald III, Jeffrey A Engelman, Frank Stegmeier, Michael R Schlabach, William C Hahn
Publikováno v:
eLife, Vol 6 (2017)
Inhibitors that target the receptor tyrosine kinase (RTK)/Ras/mitogen-activated protein kinase (MAPK) pathway have led to clinical responses in lung and other cancers, but some patients fail to respond and in those that do resistance inevitably occur
Externí odkaz:
https://doaj.org/article/91aa16d9c6ee4f3db98bf405c26f0785
Autor:
Haikuo Zhang, Christine Fillmore Brainson, Shohei Koyama, Amanda J. Redig, Ting Chen, Shuai Li, Manav Gupta, Carolina Garcia-de-Alba, Margherita Paschini, Grit S. Herter-Sprie, Gang Lu, Xin Zhang, Bryan P. Marsh, Stephanie J. Tuminello, Chunxiao Xu, Zhao Chen, Xiaoen Wang, Esra A. Akbay, Mei Zheng, Sangeetha Palakurthi, Lynette M. Sholl, Anil K. Rustgi, David J. Kwiatkowski, J Alan Diehl, Adam J. Bass, Norman E. Sharpless, Glenn Dranoff, Peter S. Hammerman, Hongbin Ji, Nabeel Bardeesy, Dieter Saur, Hideo Watanabe, Carla F. Kim, Kwok-Kin Wong
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
The mechanisms that govern the transdifferentiation of lung adenocarcinomas (ADC) to squamous cell carcinoma (SCC) are not fully understood. Here, the authors show that EZH2 loss exacerbates the transdifferentiation of ADCs to SCCs as a result of chr
Externí odkaz:
https://doaj.org/article/0ce62822a53e4bae828250fb78660d57
Autor:
Pasi A. Jänne, Yu Imamura, Daniel B. Costa, Paul A. VanderLaan, Amanda J. Redig, Emily S. Chambers, Marzia Capelletti, Richard B. Lanman, Rebecca J. Nagy, Mizuki Nishino, Hideo Baba, Masayuki Watanabe, Paul T. Kirschmeier, Cloud P. Paweletz, Bryan C. Ulrich, Giulia C. Leonardi, Elena V. Ivanova, Jihyun Choi, Sangeetha Palakurthi, Stephen Wang, Man Xu, Frederick H. Wilson, Lynette M. Sholl, Mark M. Awad, Magda Bahcall
Detailed description of methodology and reagents
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37969b8d5e0762e7d773b7b6d2aee3e3
https://doi.org/10.1158/1078-0432.22469682
https://doi.org/10.1158/1078-0432.22469682
Autor:
Pasi A. Jänne, Poornima Chalasani, Yunling Shi, Caitlin Fontes, Stacy Mach, Lynette M. Sholl, Suzanne E. Dahlberg, Marzia Capelletti, Amanda J. Redig
Supplemental Table 1: Identified NF1 variants; Supplemental Table 2: Tumors with multiple NF1 mutations include splice site, missense, nonsense, and frameshift mutations; Supplemental Table 3: KRAS mutations identified by next-generation sequencing.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ed0155314c6c80008f259cfb48551a9
https://doi.org/10.1158/1078-0432.22457816.v1
https://doi.org/10.1158/1078-0432.22457816.v1
Autor:
Chiara Ambrogio, Pasi A. Jänne, Mark M. Awad, Prafulla C. Gokhale, David Santamaria, Marie-Julie Nokin, Elodie Richard, Yunhan Chen, Kshiti H. Dholakia, Jens Köhler, Amanda J. Redig, Chhayheng Chhoeu, Joao Victor Alessi, Yue Xu, Jiaqi Li, Heidi M. Haikala, Mika Lin, Haiyun Wang, Raymond Paranal, Xinan Wang, Yoonji Eum, Enrico Patrucco, Alessia Mira, Jeffrey J. Okoro, Jieun Son, Biagio Ricciuti
Supplementary Data from Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non–Small Cell Lung Cancer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e908ecdb4bf36d5ab7cc98336d10d7d
https://doi.org/10.1158/1078-0432.22484111.v1
https://doi.org/10.1158/1078-0432.22484111.v1
Autor:
Pasi A. Jänne, David M. Jackman, Daniel B. Costa, Bruce E. Johnson, Geoffrey R. Oxnard, David Boucher, Myriam Taibi, Nora Feeney, Allison O'Connell, Suzanne E. Dahlberg, Cloud P. Paweletz, Amanda J. Redig, Masahiko Yanagita
Supplementary Figure Legend
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e989eb02f9e388be11446066a5b7746
https://doi.org/10.1158/1078-0432.22468266.v1
https://doi.org/10.1158/1078-0432.22468266.v1
Autor:
Pasi A. Jänne, Yu Imamura, Daniel B. Costa, Paul A. VanderLaan, Amanda J. Redig, Emily S. Chambers, Marzia Capelletti, Richard B. Lanman, Rebecca J. Nagy, Mizuki Nishino, Hideo Baba, Masayuki Watanabe, Paul T. Kirschmeier, Cloud P. Paweletz, Bryan C. Ulrich, Giulia C. Leonardi, Elena V. Ivanova, Jihyun Choi, Sangeetha Palakurthi, Stephen Wang, Man Xu, Frederick H. Wilson, Lynette M. Sholl, Mark M. Awad, Magda Bahcall
Next generation sequencing copy number plots for Case #2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3503cca1311b251af5a159338aab0305
https://doi.org/10.1158/1078-0432.22469700.v1
https://doi.org/10.1158/1078-0432.22469700.v1
Autor:
Leonidas C. Platanias, Sharon Barr, Suzanne Russo, Amanda J. Redig, Barbara Kroczynska, Heather Glaser, Surinder Kaur, Antonella Sassano, Jessica K. Altman
Purpose: To determine whether mTORC2 and rapamycin-insensitive (RI)-mTORC1 complexes are present in acute myeloid leukemia (AML) cells and to examine the effects of dual mTORC2/mTORC1 inhibition on primitive AML leukemic progenitors.Experimental Desi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbce5ce4074acb8cf0520e0d3138534d
https://doi.org/10.1158/1078-0432.c.6519228
https://doi.org/10.1158/1078-0432.c.6519228
Autor:
Pasi A. Jänne, David M. Jackman, Daniel B. Costa, Bruce E. Johnson, Geoffrey R. Oxnard, David Boucher, Myriam Taibi, Nora Feeney, Allison O'Connell, Suzanne E. Dahlberg, Cloud P. Paweletz, Amanda J. Redig, Masahiko Yanagita
Shown is the schema of study design and enrollment.(30) As noted, the cut-off for data analysis was May 15, 2015.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ab4b7626cb9d82186aaf8d061efb44e
https://doi.org/10.1158/1078-0432.22468272
https://doi.org/10.1158/1078-0432.22468272