Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amanda J Linke"'
Autor:
Patricia L Theard, Erin Sheffels, Nancy E Sealover, Amanda J Linke, David J Pratico, Robert L Kortum
Publikováno v:
eLife, Vol 9 (2020)
Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of
Externí odkaz:
https://doaj.org/article/4511fbc1380749d192e9b877015f7dca
Autor:
Patricia L. Theard, Amanda J. Linke, Nancy E. Sealover, Brianna R. Daley, Johnny Yang, Katherine Cox, Robert L. Kortum
Publikováno v:
Molecular Oncology, Vol 18, Iss 3, Pp 641-661 (2024)
Son of sevenless 1 and 2 (SOS1 and SOS2) are RAS guanine nucleotide exchange factors (RasGEFs) that mediate physiologic and pathologic receptor tyrosine kinase (RTK)‐dependent RAS activation. Here, we show that SOS2 modulates the threshold of epide
Externí odkaz:
https://doaj.org/article/1c1ff9a6c36d40abb84f70fb414016e7
Autor:
Nancy E. Sealover, Jacob M. Hughes, Patricia L. Theard, Deepan Chatterjee, Amanda J. Linke, Bridget A. Finniff, Brianna R. Daley, Robert E. Lewis, Robert L. Kortum
Publikováno v:
STAR Protocols, Vol 5, Iss 4, Pp 103361- (2024)
Summary: Acquired resistance to oncogene-targeted therapies is the major driver of mortality for patients with cancer. Here, we present a 6-to-16-week assay to model the development of acquired resistance in adherent and suspension cancer cell lines.
Externí odkaz:
https://doaj.org/article/f0666369e1db465b8a5f5a2b715e72c7
Autor:
Nancy E. Sealover, Patricia T. Theard, Jacob M. Hughes, Amanda J. Linke, Brianna R. Daley, Robert L. Kortum
Publikováno v:
iScience, Vol 27, Iss 1, Pp 108711- (2024)
Summary: Intrinsic and acquired resistance limit the window of effectiveness for oncogene-targeted cancer therapies. Here, we describe an in situ resistance assay (ISRA) that reliably models acquired resistance to RTK/RAS-pathway-targeted therapies a
Externí odkaz:
https://doaj.org/article/935f01a0ae87470eb58212d48ccf07d4
Autor:
Nancy E. Sealover, Patricia L. Theard, Amanda J. Linke, Jacob M. Hughes, Brianna R. Daley, Robert L. Kortum
Publikováno v:
bioRxiv
Intrinsic and acquired resistance limit the window of effectiveness for oncogene-targeted cancer therapies. Preclinical studies that identify synergistic combinations enhance therapeutic efficacy to target intrinsic resistance, however, methods to st
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1d87104205dce490e63c22af59fe504
https://europepmc.org/articles/PMC9901014/
https://europepmc.org/articles/PMC9901014/
Autor:
Patricia L. Theard, Amanda J. Linke, Nancy E. Sealover, Brianna R. Daley, Johnny Yang, Katherine Cox, Robert L Kortum
Son of Sevenless 1 and 2 (SOS1 and SOS2) are RAS guanine nucleotide exchange factors (RasGEFs) that mediate physiologic and pathologic RTK-dependent RAS activation. Here, we show that SOS2 modulates the threshold of epidermal growth factor receptor (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d3c242ad978fba81ebcf544f47ced72b
https://doi.org/10.1101/2023.01.20.524989
https://doi.org/10.1101/2023.01.20.524989
Autor:
Julia E Lefler, Catherine B MarElia-Bennett, Katie A Thies, Blake E Hildreth, Sudarshana M Sharma, Jason R Pitarresi, Lu Han, Caroline Everett, Christopher Koivisto, Maria C Cuitino, Cynthia D Timmers, Elizabeth O’Quinn, Melodie Parrish, Martin J Romeo, Amanda J Linke, G Aaron Hobbs, Gustavo Leone, Denis C Guttridge, Teresa A Zimmers, Gregory B Lesinski, Michael C Ostrowski
Publikováno v:
Life Science Alliance. 5:e202201460
Pancreatic ductal adenocarcinoma (PDAC) is associated with an incredibly dense stroma, which contributes to its recalcitrance to therapy. Cancer-associated fibroblasts (CAFs) are one of the most abundant cell types within the PDAC stroma and have con
Autor:
Erin Sheffels, Patricia L. Theard, Amanda J Linke, David J Pratico, Nancy E. Sealover, Robert L. Kortum
Publikováno v:
eLife, Vol 9 (2020)
eLife
eLife
Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of
Autor:
Erin Sheffels, Nancy E. Sealover, Robert L. Kortum, Amanda J Linke, David J Pratico, Patricia L. Theard
Drug treatment of 3D cancer spheroids more accurately reflects in vivo therapeutic responses compared to adherent culture studies. In EGFR-mutated lung adenocarcinoma, EGFR-TKIs show enhanced efficacy in spheroid cultures. Simultaneous inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93277b7f3b42a25c7af098ad3e5445b3