Zobrazeno 1 - 10
of 64
pro vyhledávání: '"Amanda J Lea"'
Publikováno v:
eLife, Vol 12 (2024)
Previously, we showed that a massively parallel reporter assay, mSTARR-seq, could be used to simultaneously test for both enhancer-like activity and DNA methylation-dependent enhancer activity for millions of loci in a single experiment (Lea et al.,
Externí odkaz:
https://doaj.org/article/9db658a652954aa287f21a59463a74d1
Autor:
Amanda J Lea, Andrew G Clark, Andrew W Dahl, Orrin Devinsky, Angela R Garcia, Christopher D Golden, Joseph Kamau, Thomas S Kraft, Yvonne A L Lim, Dino J Martins, Donald Mogoi, Päivi Pajukanta, George H Perry, Herman Pontzer, Benjamin C Trumble, Samuel S Urlacher, Vivek V Venkataraman, Ian J Wallace, Michael Gurven, Daniel E Lieberman, Julien F Ayroles
Publikováno v:
PLoS Biology, Vol 21, Iss 9, p e3002311 (2023)
Noncommunicable diseases (NCDs) are on the rise worldwide. Obesity, cardiovascular disease, and type 2 diabetes are among a long list of "lifestyle" diseases that were rare throughout human history but are now common. The evolutionary mismatch hypoth
Externí odkaz:
https://doaj.org/article/2745ad47e80c435daa7ab7fa5ed0c557
Autor:
Ian J Wallace, Amanda J Lea, Yvonne A L Lim, Steven K W Chow, Izandis bin Mohd Sayed, Romano Ngui, Mohd Tajudin Haji Shaffee, Kee-Seong Ng, Colin Nicholas, Vivek V Venkataraman, Thomas S Kraft
Publikováno v:
BMJ Open, Vol 12, Iss 9 (2022)
Introduction Non-communicable disease (NCD) risk is influenced by environmental factors that are highly variable worldwide, yet prior research has focused mainly on high-income countries where most people are exposed to relatively homogeneous and sta
Externí odkaz:
https://doaj.org/article/1a67ea8fe9564987aa8e3191c7e1a6e4
Autor:
Corbin SC Johnson, Carol A Shively, Kristofer T Michalson, Amanda J Lea, Ryne J DeBo, Timothy D Howard, Gregory A Hawkins, Susan E Appt, Yongmei Liu, Charles E McCall, David M Herrington, Edward H Ip, Thomas C Register, Noah Snyder-Mackler
Publikováno v:
eLife, Vol 10 (2021)
Dietary changes associated with industrialization increase the prevalence of chronic diseases, such as obesity, type II diabetes, and cardiovascular disease. This relationship is often attributed to an ‘evolutionary mismatch’ between human physio
Externí odkaz:
https://doaj.org/article/ab97584b0c994536be61419945f11ac6
Autor:
Jordan A Anderson, Rachel A Johnston, Amanda J Lea, Fernando A Campos, Tawni N Voyles, Mercy Y Akinyi, Susan C Alberts, Elizabeth A Archie, Jenny Tung
Publikováno v:
eLife, Vol 10 (2021)
Aging, for virtually all life, is inescapable. However, within populations, biological aging rates vary. Understanding sources of variation in this process is central to understanding the biodemography of natural populations. We constructed a DNA met
Externí odkaz:
https://doaj.org/article/b042a8cf3d934517a046748cd2b3554d
Autor:
Amanda J Lea, Christopher M Vockley, Rachel A Johnston, Christina A Del Carpio, Luis B Barreiro, Timothy E Reddy, Jenny Tung
Publikováno v:
eLife, Vol 7 (2018)
Changes in DNA methylation are involved in development, disease, and the response to environmental conditions. However, not all regulatory elements are functionally methylation-dependent (MD). Here, we report a method, mSTARR-seq, that assesses the c
Externí odkaz:
https://doaj.org/article/95e79243f5504caeb4822e2fe7927ebf
Publikováno v:
PLoS Genetics, Vol 11, Iss 11, p e1005650 (2015)
Identifying sources of variation in DNA methylation levels is important for understanding gene regulation. Recently, bisulfite sequencing has become a popular tool for investigating DNA methylation levels. However, modeling bisulfite sequencing data
Externí odkaz:
https://doaj.org/article/98aaac149487409ca7fe760976848339
Autor:
Luisa F. Pallares, Amanda J. Lea, Clair Han, Elena V. Filippova, Peter Andolfatto, Julien F. Ayroles
Publikováno v:
Nature Genetics. 55:123-129
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0845919987a02923c84a8d32a474e76e
https://doi.org/10.1038/s41588-022-01246-1
https://doi.org/10.1038/s41588-022-01246-1
Publikováno v:
bioRxiv
Previously we showed that a massively parallel reporter assay, mSTARR-seq, could be used to simultaneously test for both enhancer-like activity and DNA methylation-dependent enhancer activity for millions of loci in a single experiment (Leaet al., 20
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a452c25c02d10dd602cff9aee1357e97
https://doi.org/10.1101/2023.05.19.541437
https://doi.org/10.1101/2023.05.19.541437
Autor:
Jordan A. Anderson, Amanda J. Lea, Tawni N. Voyles, Mercy Y. Akinyi, Ruth Nyakundi, Lucy Ochola, Martin Omondi, Fred Nyundo, Yingying Zhang, Fernando A. Campos, Susan C. Alberts, Elizabeth A. Archie, Jenny Tung
Publikováno v:
Philos Trans R Soc Lond B Biol Sci
The social environment is a major determinant of morbidity, mortality and Darwinian fitness in social animals. Recent studies have begun to uncover the molecular processes associated with these relationships, but the degree to which they vary across
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52c2f2e73c9051b1c3b419478ce69d41
https://pubmed.ncbi.nlm.nih.gov/35000452
https://pubmed.ncbi.nlm.nih.gov/35000452