Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Amanda J, Heslegrave"'
Autor:
Sofia Toniolo, Sijia Zhao, Anna Scholcz, Benazir Amein, Akke Ganse‐Dumrath, Amanda J. Heslegrave, Sian Thompson, Sanjay Manohar, Henrik Zetterberg, Masud Husain
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 16, Iss 2, Pp n/a-n/a (2024)
Abstract INTRODUCTION A major limitation in Alzheimer's disease (AD) research is the lack of the ability to measure cognitive performance at scale—robustly, remotely, and frequently. Currently, there are no established online digital platforms vali
Externí odkaz:
https://doaj.org/article/5f95bed881b641ef88636a298492a358
Autor:
Xiaobei Pan, Paul C. Donaghy, Gemma Roberts, Leonidas Chouliaras, John T. O’Brien, Alan J. Thomas, Amanda J. Heslegrave, Henrik Zetterberg, Bernadette McGuinness, Anthony P. Passmore, Brian D. Green, Joseph P. M. Kane
Publikováno v:
Frontiers in Aging Neuroscience, Vol 15 (2024)
BackgroundIn multifactorial diseases, alterations in the concentration of metabolites can identify novel pathological mechanisms at the intersection between genetic and environmental influences. This study aimed to profile the plasma metabolome of pa
Externí odkaz:
https://doaj.org/article/8aad56e5df91470bbb204ca5a316b750
Publikováno v:
Frontiers in Neuroscience, Vol 16 (2022)
Alzheimer’s disease (AD) is the most common neurodegenerative disease worldwide. Amyloid beta (Aβ) is one of the proteins which aggregate in AD, and its key role in the disease pathogenesis is highlighted in the amyloid cascade hypothesis, which s
Externí odkaz:
https://doaj.org/article/f4ec7407e1ec45f8af8e399e29e986e0
Autor:
Laura A. Benjamin, Ross W. Paterson, Rachel Moll, Charis Pericleous, Rachel Brown, Puja R. Mehta, Dilan Athauda, Oliver J. Ziff, Judith Heaney, Anna M. Checkley, Catherine F. Houlihan, Michael Chou, Amanda J. Heslegrave, Arvind Chandratheva, Benedict D. Michael, Kaj Blennow, Vinojini Vivekanandam, Alexander Foulkes, Catherine J. Mummery, Michael P. Lunn, Stephen Keddie, Moira J. Spyer, Tom Mckinnon, Melanie Hart, Francesco Carletti, Hans Rolf Jäger, Hadi Manji, Michael S. Zandi, David J. Werring, Eleni Nastouli, Robert Simister, Tom Solomon, Henrik Zetterberg, Jonathan M. Schott, Hannah Cohen, Maria Efthymiou
Publikováno v:
EClinicalMedicine, Vol 39, Iss , Pp 101070- (2021)
Background: A high prevalence of antiphospholipid antibodies has been reported in case series of patients with neurological manifestations and COVID-19; however, the pathogenicity of antiphospholipid antibodies in COVID-19 neurology remains unclear.
Externí odkaz:
https://doaj.org/article/3eef6c9f06c243ceb51ecb95ba2fa15f
Autor:
Ross W. Paterson, Catherine F. Slattery, Teresa Poole, Jennifer M. Nicholas, Nadia K. Magdalinou, Jamie Toombs, Miles D. Chapman, Michael P. Lunn, Amanda J. Heslegrave, Martha S Foiani, Philip S. J. Weston, Ashvini Keshavan, Jonathan D. Rohrer, Martin N. Rossor, Jason D. Warren, Catherine J. Mummery, Kaj Blennow, Nick C. Fox, Henrik Zetterberg, Jonathan M. Schott
Publikováno v:
Alzheimer’s Research & Therapy, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Background Cerebrospinal fluid (CSF) biomarkers are increasingly being used to support a diagnosis of Alzheimer’s disease (AD). Their clinical utility for differentiating AD from non-AD neurodegenerative dementias, such as dementia with Le
Externí odkaz:
https://doaj.org/article/cd0b740c050b4d6384bd565c2c72b223
Autor:
Nirosen Vijiaratnam, Michael Lawton, Amanda J Heslegrave, Tong Guo, Manuela Tan, Edwin Jabbari, Raquel Real, John Woodside, Katherine Grosset, Viorica Chelban, Dilan Athauda, Christine Girges, Roger A Barker, John Hardy, Nicholas Wood, Henry Houlden, Nigel Williams, Yoav Ben-Shlomo, Henrik Zetterberg, Donald G Grosset, Thomas Foltynie, Huw R Morris
Publikováno v:
Vijiaratnam, N, Lawton, M A, Heslegrave, A, Guo, T, Tan, M, Jabbari, E, Real, R, Woodside, J, Grosset, K, Chelban, V, Athauda, D, Girges, C, Barker, R, Hardy, J, Wood, N, Houlden, H, Williams, N, Ben-Shlomo, Y, Zetterberg, H, Grosset, D, Foltynie, T & Morris, H 2022, ' Combining biomarkers for prognostic modelling of Parkinson’s disease ', Journal of Neurology, Neurosurgery, and Psychiatry, vol. 93, no. 7, pp. 707-715 . https://doi.org/10.1136/jnnp-2021-328365
BackgroundPatients with Parkinson’s disease (PD) have variable rates of progression. More accurate prediction of progression could improve selection for clinical trials. Although some variance in clinical progression can be predicted by age at onse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b5f8a1693f0ec1b935bb717ac7e0895
https://doi.org/10.1136/jnnp-2021-328365
https://doi.org/10.1136/jnnp-2021-328365
Autor:
Oliver J. Ziff, Nicholas J. Ashton, Puja R. Mehta, Rachel Brown, Dilan Athauda, Judith Heaney, Amanda J. Heslegrave, Andrea Lessa Benedet, Kaj Blennow, Anna M. Checkley, Catherine F. Houlihan, Serge Gauthier, Pedro Rosa‐Neto, Nick C. Fox, Jonathan M. Schott, Henrik Zetterberg, Laura A. Benjamin, Ross W. Paterson
Publikováno v:
Journal of Neurochemistry. 161:146-157
SARS-CoV-2 infection can damage the nervous system with multiple neurological manifestations described. However, there is limited understanding of the mechanisms underlying COVID-19 neurological injury. This is a cross-sectional exploratory prospecti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6734b75afe40bffba0baf377989f1bff
https://doi.org/10.1111/jnc.15585
https://doi.org/10.1111/jnc.15585
Autor:
Antoinette O'Connor, Emily Abel, Andrea Lessa Benedet, Teresa Poole, Nicholas Ashton, Philip Simon John Weston, Amanda J Heslegrave, Natalie Ryan, Suzie Barker, James M Polke, Kaj Blennow, Henrik Zetterberg, Nick C Fox
Publikováno v:
Journal of Neurology, Neurosurgery, and Psychiatry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c79c5abc333d4e442bc0e13b713306e
https://doi.org/10.1136/jnnp-2022-329663
https://doi.org/10.1136/jnnp-2022-329663
Autor:
Anna M. Zeitlberger, Gilbert Thomas-Black, Hector Garcia-Moreno, Martha Foiani, Amanda J. Heslegrave, Henrik Zetterberg, Paola Giunti
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 12 (2018)
Background: Friedreich’s ataxia (FRDA) is the most common autosomal recessive ataxia. Disease-modifying treatments are not available yet; however, several compounds are currently under investigation. As a result, there is a growing need for the ide
Externí odkaz:
https://doaj.org/article/8699012435b74306bee3db31ed991dd9
Autor:
Ross W. Paterson, Jamie Toombs, Miles D. Chapman, Jennifer M. Nicholas, Amanda J. Heslegrave, Catherine F. Slattery, Alexander J.M. Foulkes, Camilla N. Clark, Christopher A.S. Lane, Philip S.J. Weston, Michael P. Lunn, Nick C. Fox, Henrik Zetterberg, Jonathan M. Schott
Publikováno v:
Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 1, Iss 3, Pp 380-384 (2015)
Abstract Introduction Cerebrospinal fluid (CSF) neurodegenerative markers are measured clinically to support a diagnosis of Alzheimer's disease. Several preanalytical factors may alter the CSF concentrations of amyloid β 1–42 (Aβ1–42) in partic
Externí odkaz:
https://doaj.org/article/13480e2160d744c9985b1d432b6a50d2