Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Amanda Hunkele"'
Autor:
Václav Havel, Andrew C. Kruegel, Benjamin Bechand, Scot McIntosh, Leia Stallings, Alana Hodges, Madalee G. Wulf, Mel Nelson, Amanda Hunkele, Michael Ansonoff, John E. Pintar, Christopher Hwu, Rohini S. Ople, Najah Abi-Gerges, Saheem A. Zaidi, Vsevolod Katritch, Mu Yang, Jonathan A. Javitch, Susruta Majumdar, Scott E. Hemby, Dalibor Sames
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)
Abstract Ibogaine and its main metabolite noribogaine provide important molecular prototypes for markedly different treatment of substance use disorders and co-morbid mental health illnesses. However, these compounds present a cardiac safety risk and
Externí odkaz:
https://doaj.org/article/a56405d25d8040d397ce8623055b504b
Autor:
Srijita Bhowmik, Juraj Galeta, Václav Havel, Melissa Nelson, Abdelfattah Faouzi, Benjamin Bechand, Mike Ansonoff, Tomas Fiala, Amanda Hunkele, Andrew C. Kruegel, John. E. Pintar, Susruta Majumdar, Jonathan A. Javitch, Dalibor Sames
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Mitragynine (MG) is an indole alkaloid from kratom plant that binds opioid receptors and as such presents a scaffold for the development of atypical opioid receptor modulators. Here, the authors report a synthetic method for selective functionalizati
Externí odkaz:
https://doaj.org/article/ea38af09c9b14aa088b91f729a3dae52
Autor:
Rajendra Uprety, Tao Che, Saheem A Zaidi, Steven G Grinnell, Balázs R Varga, Abdelfattah Faouzi, Samuel T Slocum, Abdullah Allaoa, András Varadi, Melissa Nelson, Sarah M Bernhard, Elizaveta Kulko, Valerie Le Rouzic, Shainnel O Eans, Chloe A Simons, Amanda Hunkele, Joan Subrath, Ying Xian Pan, Jonathan A Javitch, Jay P McLaughlin, Bryan L Roth, Gavril W Pasternak, Vsevolod Katritch, Susruta Majumdar
Publikováno v:
eLife, Vol 10 (2021)
Controlling receptor functional selectivity profiles for opioid receptors is a promising approach for discovering safer analgesics; however, the structural determinants conferring functional selectivity are not well understood. Here, we used crystal
Externí odkaz:
https://doaj.org/article/dc31183697a3454e95268139bbe3d9fd
Publikováno v:
PLoS Computational Biology, Vol 15, Iss 1, p e1006689 (2019)
The differential modulation of agonist and antagonist binding to opioid receptors (ORs) by sodium (Na+) has been known for decades. To shed light on the molecular determinants, thermodynamics, and kinetics of Na+ translocation through the μ-OR (MOR)
Externí odkaz:
https://doaj.org/article/44ff0c4c73524bdca52bb6fed6851377
Autor:
Bronwyn M. Kivell, Shainnel O. Eans, Abdullah Allaoa, András Váradi, Lisa L. Wilson, Gavril W. Pasternak, Rajendra Uprety, Andrew C. Kruegel, John E. Pintar, Xiaohai Li, Samuel T. Slocum, Takeshi Irie, Jay P. McLaughlin, Brittany Scouller, Amy F. Alder, Michael D. Cameron, Sanjay Kalra, Ying-Xian Pan, Amanda Hunkele, Susruta Majumdar, Michael Ansonoff, Valerie Le Rouzic, Dalibor Sames, Soumen Chakraborty, Jin Xu
Publikováno v:
J Med Chem
The leaves of Mitragyna speciosa (kratom), a plant native to Southeast Asia, are increasingly used as a pain reliever and for attenuation of opioid withdrawal symptoms. Using the tools of natural products chemistry, chemical synthesis, and pharmacolo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::29c5e470bfb54471841442c42450dcbe
https://doi.org/10.1021/acs.jmedchem.1c01111
https://doi.org/10.1021/acs.jmedchem.1c01111
Autor:
Gavril W. Pasternak, Rahul Jilakara, Ying Xian Pan, Rajendra Uprety, Amanda Hunkele, Kevin Appourchaux, Tao Che, Amal El Daibani, Shainnel O. Eans, Jay P. McLaughlin, Lisa Thammavong, Soumen Chakraborty, Susruta Majumdar, Valerie Le Rouzic, Nitin Nuthikattu
Publikováno v:
ACS Chem Neurosci
Dry leaves of kratom (mitragyna speciosa) are anecdotally consumed as pain relievers and antidotes against opioid withdrawal and alcohol use disorders. There are at least 54 alkaloids in kratom; however, investigations to date have focused around mit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0f9ab884ac5d9cba2e1fd0c77fb83a5
https://doi.org/10.1021/acschemneuro.1c00149
https://doi.org/10.1021/acschemneuro.1c00149
Autor:
Ying-Xian Pan, Andras Varadi, Gavril W. Pasternak, Joan J. Subrath, Amanda Hunkele, Susruta Majumdar, Rajendra Uprety, Steven G. Grinnell
Publikováno v:
Cell Mol Neurobiol
Mu opioid receptors (MOR-1) mediate the biological actions of clinically used opioids such as morphine, oxycodone, and fentanyl. The mu opioid receptor gene, OPRM1, undergoes extensive alternative splicing, generating multiple splice variants. One ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd285a387e4ab2ac4374c638883eab5a
https://doi.org/10.1007/s10571-020-00867-6
https://doi.org/10.1007/s10571-020-00867-6
Autor:
Leia Stallings, Dalibor Sames, Saheem A. Zaidi, Mike Ansonoff, Mu Yang, Andrew C. Kruegel, John E. Pintar, Madalee G. Wulf, Susruta Majumdar, Scott E. Hemby, Scot McIntosh, Alana Hodges, Najah Abi-Gerges, Amanda Hunkele, Melissa Nelson, Benjamin Bechand, Christopher Hwu, Vsevolod Katritch, Vaclav Havel, Jonathan A. Javitch
Substance use and related mental health epidemics are causing increasing suffering and death in diverse communities.1,2Despite extensive efforts focused on developing pharmacotherapies for treating substance use disorders, there is an urgent need for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa5fecd29440dbb1136a7e1684958343
https://doi.org/10.1101/2021.07.22.453441
https://doi.org/10.1101/2021.07.22.453441
Autor:
Roger S. Wilson, Takeshi Irie, Gregory W. Fischer, Ying-Xian Pan, Valerie Le Rouzic, Rebecca Shum, Amanda Hunkele, Gavril W. Pasternak, Jin Xu, Ioanna Deni
Publikováno v:
Molecular Pharmacology. 96:247-258
Circular RNAs (circRNAs) are a distinct category of single-stranded, covalently closed RNAs formed by backsplicing. The functions of circRNAs are incompletely known and are under active investigation. Here, we report that in addition to traditional l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::654fdc47142aea5b794c039a8b76abe6
https://doi.org/10.1124/mol.118.113977
https://doi.org/10.1124/mol.118.113977
Publikováno v:
The FASEB Journal. 35
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7ef2bc82d233c0d9b892e9b438b69b2
https://doi.org/10.1096/fasebj.2021.35.s1.03045
https://doi.org/10.1096/fasebj.2021.35.s1.03045