Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amanda Heard"'
Autor:
Amanda Heard, Jack H. Landmann, Ava R. Hansen, Alkmini Papadopolou, Yu-Sung Hsu, Mehmet Emrah Selli, John M. Warrington, John Lattin, Jufang Chang, Helen Ha, Martina Haug-Kroeper, Balraj Doray, Saar Gill, Marco Ruella, Katharina E. Hayer, Matthew D. Weitzman, Abby M. Green, Regina Fluhrer, Nathan Singh
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-11 (2022)
Loss of surface CD19 expression by leukemic cells leads to resistance and relapse to CD19-targeted CAR-T therapies. Here the authors show that loss of SPPL3 in malignant B cells results in hyperglycosylation of CD19.
Externí odkaz:
https://doaj.org/article/0f7c94a068e44180b9af36e2164d17d4
Autor:
Mehmet Emrah Selli, Jack Landmann, Marina Terekhova, John Lattin, Amanda Heard, Yu-Sung Hsu, Tien-Ching Chang, Ju-fang Chang, John M Warrington, Helen Ha, Natalie L Kingston, Graham Hogg, Michael Slade, Melissa M Berrien-Elliott, Mark Foster, Samantha Kersting-Schadek, Agata Gruszczynska, David DeNardo, Todd A Fehniger, Maxim Artyomov, Nathan Singh
Publikováno v:
bioRxiv
T cells engineered to express chimeric antigen receptors (CARs) targeting CD19 have demonstrated impressive activity against relapsed or refractory B cell cancers yet fail to induce durable remissions for nearly half of patients treated. Enhancing th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa7a2644e8cc9f45e51569d91c0b648e
https://doi.org/10.1101/2023.01.26.525725
https://doi.org/10.1101/2023.01.26.525725
Autor:
Mehmet Emrah Selli, Jack Landmann, John Lattin, Amanda Heard, John Warrington, Helen Ha, Jufang Chang, Natalie Kingston, Graham Hogg, Mark Foster, Samantha Kersting-Schadek, Marina Terekhova, David DeNardo, Todd A. Fehniger, Maxim Artyomov, Nathan Singh
Publikováno v:
Blood. 140:2354-2355
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a210822bfce2783bc77d669e3e75385
https://doi.org/10.1182/blood-2022-159687
https://doi.org/10.1182/blood-2022-159687
Autor:
Amanda Heard, Faisal Rafi, Harshini Vasudevanallur Subra, Saeid Vafaei, Stephan Lucas, Daichi Inoue, Takashi Sugiura, Kazuhiro Manseki
Publikováno v:
Proceeding of 7th Thermal and Fluids Engineering Conference (TFEC).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ace233fe89eb4452c66d5d0eac7aa99
https://doi.org/10.1615/tfec2022.ens.040977
https://doi.org/10.1615/tfec2022.ens.040977
Autor:
Ajay Khanna, Timothy A. Graubert, Brian A. Wadugu, Matthew Ndonwi, Michael O. Alberti, Tanzir Ahmed, Matthew J. Walter, Jie Liu, Jin Shao, Dennis L. Fei, Amanda Heard, Christopher A. Miller, Cara Lunn Shirai, Joseph Bradley, Sarah Grieb, Sridhar Nonavinkere Srivatsan
Publikováno v:
J Clin Invest
Somatic mutations in the spliceosome gene U2AF1 are common in patients with myelodysplastic syndromes. U2AF1 mutations that code for the most common amino acid substitutions are always heterozygous, and the retained wild-type allele is expressed, sug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ced69eb58de896ff3661794ad6c355c4
https://doi.org/10.1172/jci141401
https://doi.org/10.1172/jci141401
Autor:
Michael O. Alberti, Ajay Khanna, Cara Lunn Shirai, Christopher A. Miller, Sarah Grieb, Dennis L. Fei, Jin Shao, Matthew J. Walter, Tanzir Ahmed, Matthew Ndonwi, Timothy A. Graubert, Brian A. Wadugu, Sridhar Nonavinkere Srivatsan, Amanda Heard, Joseph Bradley
Somatic mutations in the spliceosome geneU2AF1are common in patients with myelodysplastic syndromes.U2AF1mutations that code for the most common amino acid substitutions are always heterozygous, and the retained wild-type allele is expressed, suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e54bfd655f7b34760b9b249df3e068c0
https://doi.org/10.1101/2020.06.20.151035
https://doi.org/10.1101/2020.06.20.151035
Autor:
Katharina E. Hayer, Balraj Doray, Marco Ruella, Amanda Heard, Jufang Chang, Matthew D. Weitzman, Saar Gill, John Lattin, Nathan Singh, Regina Fluhrer, Jack Landmann, Mehmet Emrah Selli, Helen Ha, Abby M. Green
Publikováno v:
Blood. 138:1721-1721
Chimeric antigen receptor-engineered T cells targeting CD19 (CART19) have revolutionized the management of relapsed and refractory B cell malignancies. Despite high initial response rates, many patients with acute lymphoblastic leukemia (ALL) ultimat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fa8d5a31dd2ad49424e14d7113732bbe
https://doi.org/10.1182/blood-2021-146651
https://doi.org/10.1182/blood-2021-146651
Publikováno v:
Best Practice & Research Clinical Haematology. 34:101304
Chimeric antigen receptor (CAR) T cells have revolutionized the management of B cell malignancies. These synthetic molecules are composed of peptide fragments from several distinct immune cell proteins and link highly-specific antigen recognition wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2029ebc41cd99f1ddcf0b30901eb8c36
https://doi.org/10.1016/j.beha.2021.101304
https://doi.org/10.1016/j.beha.2021.101304
Publikováno v:
Blood. 132:941-941
Somatic mutations in U2AF1, a spliceosome gene involved in pre-mRNA splicing, occur in up to 11% of MDS patients. While we reported that mice expressing mutant U2AF1(S34F) have altered hematopoiesis and RNA splicing, similar to mutant MDS patients, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d98c5e54384ad56888bd4b8e57dc582b
https://doi.org/10.1182/blood-2018-99-110836
https://doi.org/10.1182/blood-2018-99-110836
Publikováno v:
Cancer Research. 78:5112-5112
Somatic mutations in genes encoding factors involved in pre-mRNA splicing (i.e., spliceosome genes) have been identified in more than half of myelodysplastic syndrome (MDS) patients. We are interested in the role of U2AF1, a spliceosome gene mutated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c785b3850496bc2ca1d901dc4a179c35
https://doi.org/10.1158/1538-7445.am2018-5112
https://doi.org/10.1158/1538-7445.am2018-5112