Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Amanda H. Bolt"'
Autor:
Simon E. V. Phillips, Ivan Campeotto, Amanda H. Bolt, Adrian J. Mulholland, Marc W. van der Kamp, Arwen R. Pearson, Adam D. Daniels, Chi H. Trinh, Adam Nelson, Alan Berry
Publikováno v:
ACS Chemical Biology
N-Acetylneuraminic acid lyase (NAL) is a Class I aldolase that catalyzes the reversible condensation of pyruvate with N-acetyl-d-mannosamine (ManNAc) to yield the sialic acid N-acetylneuraminic acid (Neu5Ac). Aldolases are finding increasing use as b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9694ca73fcc3a1840f1bf98d3ae499df
https://doi.org/10.1021/cb500067z
https://doi.org/10.1021/cb500067z
Autor:
Chi H. Trinh, Alan Berry, Arwen R. Pearson, Adam Nelson, Thomas Harman, Amanda H. Bolt, Ivan Campeotto, Simon E. V. Phillips, Caitriona Dennis
Publikováno v:
Journal of Molecular Biology
The substrate specificity of Escherichia coli N-acetylneuraminic acid lyase was previously switched from the natural condensation of pyruvate with N-acetylmannosamine, yielding N-acetylneuraminic acid, to the aldol condensation generating N-alkylcarb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9c6a8b52022d57f5ac529184b14c5d3
Publikováno v:
Archives of Biochemistry and Biophysics
This review focuses on the directed evolution of aldolases with synthetically useful properties. Directed evolution has been used to address a number of limitations associated with the use of wild-type aldolases as catalysts in synthetic organic chem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::323305647791f128817ee152183b80e6
Autor:
Amanda H. Bolt, Adam Nelson, Catherine Joce, Stephen Bartlett, Simon A. Barrett, Alan Ironmonger, Thomas Woodhall
Publikováno v:
Chemistry - A European Journal. 11:6277-6285
The bisindolylmaleimides are selective protein kinase inhibitors that can adopt two limiting diastereomeric (syn and anti) conformations. The configurational stability of a range of substituted and macrocyclic bisindolylmaleimides was investigated by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6268806010d031479ccb3235f96b3381
https://doi.org/10.1002/chem.200500520
https://doi.org/10.1002/chem.200500520