Výsledky vyhledávání - "Amanda Garfinkel"

Human iPSC-CMs and in-silico technologies define mechanisms and accelerate targeted pharmacogenetics in hypertrophic cardiomyopathy

Autor: Francesca Margara, Yiangos Psaras, Zhinuo Jenny Wang, Manuel Schmid, Ruben Doste, Amanda Garfinkel, Giuliana G. Repetti, Jonathan Seidman, Christine Seidman, Blanca Rodriguez, Christopher N. Toepfer, Alfonso Bueno-Orovio

Cardiomyopathies have unresolved genotype-phenotype relationships and lack disease-specific treatments. Here we identify genotype-specific pathomechanisms and therapeutic targets combining experimental hiPSC-CM modelling and human-based cardiac elect

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d381a7c65fb10b735346455d1914602d
https://doi.org/10.1101/2022.06.08.495324

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Abstract 402: Defining Diverse Disease Pathomechanisms Across Thick And Thin Filament Hypertrophic Cardiomyopathy Variants

Autor: Francesca Margara, Manuel Schmid, Amanda Garfinkel, Jonathan G. Seidman, Júlia D. C. Marsiglia, Giuliana Repetti, Violetta Steeples, Christopher N. Toepfer, Bueno-Orovio Alfonso, Christine E. Seidman, Yiangos Psaras, Blanca Rodriguez

Publikováno v: Circulation Research. 129

Hypertrophic cardiomyopathy (HCM) affects as many as ~1 in 500 individuals, and is often typified by hyperdynamic contraction and poor cellular relaxation. HCM can be caused by mutations in a variety of key contractile proteins of the sarcomere. A la

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9e04379c23686d3af901f5d468ce982d
https://doi.org/10.1161/res.129.suppl_1.402

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Does Inflammation Mediate the Association Between Obesity and Insulin Resistance?

Autor: Olivia Frosch, Amanda Garfinkel, Alexander Mangone, Emily C. Milam, Razieh Adabimohazab, Antonio Convit

Publikováno v: Inflammation. 39:994-1003

In adult obesity, low-grade systemic inflammation is considered an important step in the pathogenesis of insulin resistance (IR). The association between obesity and inflammation is less well established in adolescents. Here, we ascertain the importa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::041a5583fde32514ef03439d1a3a85dc
https://doi.org/10.1007/s10753-016-0329-z

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Dissertation/ Thesis

Discovery of miRNA-regulated processes in mammalian development

Autor: Young, Amanda Garfinkel

Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2010.
This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.
Cataloged from

Externí odkaz: http://hdl.handle.net/1721.1/57565

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