Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Amanda G Linkous"'
Autor:
Sandeep R Bhave, David YA dadey, Rowan M Karvas, Daniel J Ferraro, Rama P Kotipatruni, Jerry J Jaboin, Andrew N Hallahan, Todd A DeWees, Amanda G Linkous, Dennis E Hallahan, Dinesh eThotala
Publikováno v:
Frontiers in Oncology, Vol 3 (2013)
Purpose: Glioblastoma multiforme (GBM) is an aggressive primary brain tumor that is radio-resistant and recurs despite aggressive surgery, chemo and radiotherapy. Autotaxin (ATX) is over expressed in various cancers including GBM and is implicated in
Externí odkaz:
https://doaj.org/article/022b308e46e34e068463337283015032
Autor:
Stephen M Schleicher, Dinesh K Thotala, Amanda G Linkous, Rong Hu, Kathleen M Leahy, Eugenia M Yazlovitskaya, Dennis E Hallahan
Publikováno v:
PLoS ONE, Vol 6, Iss 7, p e22182 (2011)
Despite wide margins and high dose irradiation, unresectable malignant glioma (MG) is less responsive to radiation and is uniformly fatal. We previously found that cytosolic phospholipase A2 (cPLA(2)) is a molecular target for radiosensitizing cancer
Externí odkaz:
https://doaj.org/article/be184eebf7ae4b8ab66ebf0c09a38f7d
Autor:
Stefano M. Cirigliano, Andrew J. Storaska, Ken Miyaguchi, Kalyani Chadalavada, Howard A. Fine, Amanda G. Linkous, Ying Lin, Gouri Nanjangud, Batsheva Reich, Leona Cohen-Gould, Teresa A. Milner, Richa Singhania, Yasumi Nakayama, Emily Schenkein, Tarig Magdeldin, Conor Liston, Matija Snuderl, Demosthenes Balamatsias, David J. Pisapia, Lincoln A. Edwards
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3203-3211.e5 (2019)
Summary: The prognosis of patients with glioblastoma (GBM) remains dismal, with a median survival of approximately 15 months. Current preclinical GBM models are limited by the lack of a “normal” human microenvironment and the inability of many tu
Autor:
Howard A. Fine, Amanda G. Linkous
Publikováno v:
STAR Protocols
STAR Protocols, Vol 1, Iss 1, Pp 100008-(2020)
STAR Protocols, Vol 1, Iss 1, Pp 100008-(2020)
Summary Glioblastoma (GBM) remains a devastating disease with a median survival of less than two years. Current preclinical models are unable to accurately reflect the complexity of human GBM. We recently established a cerebral organoid glioma (GLICO
Autor:
Stefano M. Cirigliano, Matija Snuderl, Amanda G. Linkous, Howard A. Fine, Theodore H. Schwartz, Ken Miyaguchi, David J. Pisapia, Rohan Ramakrishna, Richa Singhania, Lincoln A. Edwards, Olivier Elemento, Yang Hu, James G. Nicholson, Allison R. Pine
Publikováno v:
Cancer Discov
Glioblastoma (GBM), an incurable tumor, remains difficult to model and more importantly to treat due to its genetic/epigenetic heterogeneity and plasticity across cellular states. The ability of current tumor models to recapitulate the cellular state
Autor:
Galina I. Belova, Margaret C. Cam, Jennifer Walling, Mehmet Baysan, Susie Ahn, Hua Song, Wei Zhang, Howard A. Fine, Amanda G. Linkous, Kevin D. Woolard, Svetlana Kotliarova, Demosthenes Balamatsias
Publikováno v:
International Journal of Cancer. 141:2002-2013
Intratumoral heterogeneity at the genetic, epigenetic, transcriptomic, and morphologic levels is a commonly observed phenomenon in many aggressive cancer types. Clonal evolution during tumor formation and in response to therapeutic intervention can b
Publikováno v:
Current Angiogenesis. 1:72-80
Autor:
Amanda G. Linkous, Andrew J. Storaska, Jennifer Walling, Hong Sug Kim, Howard A. Fine, Susie Ahn, Galina I. Belova, Gregory Riddick, Svetlana Kotliarova, Virginia Rodriguez
Publikováno v:
Scientific Reports
Glioblastoma, the most common primary malignant brain tumor, harbors a small population of tumor initiating cells (glioblastoma stem cells) that have many properties similar to neural stem cells. To investigate common regulatory networks in both neur
Publikováno v:
Cancer Letters. 304:137-143
In ovarian cancer, the molecular targeted chemotherapeutics could increase the efficiency of low-dose radiotherapy while decreasing injury to adjusted organs. In irradiated A2780 human ovarian carcinoma cells, cytosolic phospholipase A2 (cPLA(2)) inh
Publikováno v:
Cellular Microbiology. 12:1369-1377
As efficient catalysts, enzymes help maintain a variety of biological and chemical transformations necessary for cellular metabolism and normal physiology. Unfortunately, pathogenic microbes can also exploit enzymatic reactions in an attempt to sprea