Structural insights and molecular dynamics into the inhibitory mechanism of a Kunitz-type trypsin inhibitor from Tamarindus indica L

Autor: Amanda Fernandes de Medeiros, Beatriz Blenda Pinheiro de Souza, Lucas Pinheiro Coutinho, Aline Melro Murad, Paula Ivani Medeiros dos Santos, Norberto de Kássio Vieira Monteiro, Elizeu Antunes dos Santos, Bruna Leal Lima Maciel, Ana Heloneida de Araújo Morais

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 480-490 (2021)

Trypsin inhibitors from tamarind seed have been studied in vitro and in preclinical studies for the treatment of obesity, its complications and associated comorbidities. It is still necessary to fully understand the structure and behaviour of these m

Externí odkaz: https://doaj.org/article/0e2a7c5b17194f29b89fe15367ca5315

Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

Autor: Amanda Fernandes de Medeiros, Izael de Sousa Costa, Fabiana Maria Coimbra de Carvalho, Sumika Kiyota, Beatriz Blenda Pinheiro de Souza, Daniel Nogoceke Sifuentes, Raphael Paschoal Serquiz, Bruna Leal Lima Maciel, Adriana Ferreira Uchôa, Elizeu Antunes dos Santos, Ana Heloneida de Araújo Morais

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 334-348 (2018)

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and le

Externí odkaz: https://doaj.org/article/bf10a091414d47a9a9f8b24c94232dd2

Tamarind (Tamarindus indica L.) Seed a Candidate Protein Source with Potential for Combating SARS-CoV-2 Infection in Obesity

Autor: Thaís Souza Passos, Amanda Fernandes de Medeiros, Isaiane Medeiros, Anna Beatriz Santana Luz, Bruna Leal Lima Maciel, Ana Heloneida de Araújo Morais, Vanessa Cristina Oliveira de Lima

Publikováno v: Drug Target Insights
Drug Target Insights, Vol 15, Iss 1 (2021)

Introduction: Obesity and coronavirus disease (COVID)-19 are overlapping pandemics, and one might worsen the other. Methods: This narrative review discusses one of the primary mechanisms to initiate acute respiratory distress syndrome, uncontrolled s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f38e0d44afdf578da34e48e1ce6235c8
http://europepmc.org/articles/PMC8025844

Insulin-Like Proteins in Plant Sources: A Systematic Review

Autor: Amanda Fernandes de Medeiros, Grasiela Piuvezam, Izael de Sousa Costa, Ana Heloneida A Morais Morais, Gidyenne Cbs Medeiros, Bruna Ll Maciel

Publikováno v: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 13:3421-3431

Type 2 diabetes mellitus (T2DM) is characterized by hyperglycemia. Proteins in plant sources that enable the maintenance of the glycemic profile may be of interest in the context of T2DM. However, their mechanisms of action are unclear, unlike other

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::77135c9cb057e9f026c001a16bfe8c45
https://doi.org/10.2147/dmso.s256883

Biochemical characterisation of a Kunitz-type inhibitor from Tamarindus indica L. seeds and its efficacy in reducing plasma leptin in an experimental model of obesity

Autor: Daniel Nogoceke Sifuentes, Adriana F. Uchoa, Beatriz Blenda Pinheiro de Souza, Ana Heloneida de Araújo Morais, Bruna Leal Lima Maciel, Amanda Fernandes de Medeiros, Izael de Sousa Costa, Raphael Paschoal Serquiz, Elizeu Antunes dos Santos, Fabiana Maria Coimbra de Carvalho, Sumika Kiyota

Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 334-348 (2018)
Journal of Enzyme Inhibition and Medicinal Chemistry
Repositório Institucional da EMBRAPA (Repository Open Access to Scientific Information from EMBRAPA-Alice)
Empresa Brasileira de Pesquisa Agropecuária (Embrapa)
instacron:EMBRAPA

A trypsin inhibitor isolated from tamarind seed (TTI) has satietogenic effects in animals, increasing the cholecystokinin (CCK) in eutrophy and reducing leptin in obesity. We purified TTI (pTTI), characterised, and observed its effect upon CCK and le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abf7ba58c8820dadd6180be242986a49
https://doaj.org/article/bf10a091414d47a9a9f8b24c94232dd2