Zobrazeno 1 - 10
of 79
pro vyhledávání: '"Amanda E. Hargrove"'
Autor:
Jesse Davila-Calderon, Neeraj N. Patwardhan, Liang-Yuan Chiu, Andrew Sugarman, Zhengguo Cai, Srinivasa R. Penutmutchu, Mei-Ling Li, Gary Brewer, Amanda E. Hargrove, Blanton S. Tolbert
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Human enterovirus 71 (EV71) contains an internal ribosome entry site (IRES) that promotes translation of viral RNA. Here the authors show that an antiviral small molecule DMA-135 binds to the EV71 IRES RNA, inducing conformational change and stabiliz
Externí odkaz:
https://doaj.org/article/d51fcb6310e94966bfd95fb336390ef7
Autor:
Martina Zafferani, Justin G. Martyr, Dhanasheel Muralidharan, Nadeska I. Montalvan, Zhengguo Cai, Amanda E. Hargrove
Publikováno v:
ACS chemical biology. 17(9)
The rapidly accelerating characterization of RNA tertiary structures has revealed their pervasiveness and active roles in human diseases. Small molecule-mediated modulation of RNA tertiary structures constitutes an attractive avenue for the developme
Publikováno v:
RNA. 29:473-488
RNA structures regulate a wide range of processes in biology and disease, yet small molecule chemical probes or drugs that can modulate these functions are rare. Machine learning and other computational methods are well poised to fill gaps in knowled
Autor:
Peter B. Dervan, Jevgenij A. Raskatov, Benjamin C. Li, Amanda E. Hargrove, Jerzy O. Szablowski, Nicholas G. Nickols
PDF File - 43K, Structures of Py-Im polyamides used in the study.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c9d01537fd73ab03a001cb84685a117
https://doi.org/10.1158/1535-7163.22497396.v1
https://doi.org/10.1158/1535-7163.22497396.v1
Autor:
Peter B. Dervan, Jevgenij A. Raskatov, Benjamin C. Li, Amanda E. Hargrove, Jerzy O. Szablowski, Nicholas G. Nickols
PDF File - 98K, Supplementary Figure and Table Captions.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21af5a5ebf46ea2b5c0581782d41f6e0
https://doi.org/10.1158/1535-7163.22497372.v1
https://doi.org/10.1158/1535-7163.22497372.v1
Autor:
Peter B. Dervan, Jevgenij A. Raskatov, Benjamin C. Li, Amanda E. Hargrove, Jerzy O. Szablowski, Nicholas G. Nickols
PDF File - 45K, Table of genes up- or down- regulated by 2- and 4- fold by E2 or 1 (1.0 �M), with FPKM > 20.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e1c0fa87f0228c7047d832e942a0ec7
https://doi.org/10.1158/1535-7163.22497369.v1
https://doi.org/10.1158/1535-7163.22497369.v1
Autor:
Peter B. Dervan, Jevgenij A. Raskatov, Benjamin C. Li, Amanda E. Hargrove, Jerzy O. Szablowski, Nicholas G. Nickols
PDF File - 16K, qRT-PCR analysis of Tff1 mRNA reduction after treatment with 1 for 96h is dose responsive.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bf2b464040df0c61be2f4515b0275bc
https://doi.org/10.1158/1535-7163.22497390
https://doi.org/10.1158/1535-7163.22497390
Autor:
Peter B. Dervan, Jevgenij A. Raskatov, Benjamin C. Li, Amanda E. Hargrove, Jerzy O. Szablowski, Nicholas G. Nickols
PDF File - 31K, Relative mRNA of E2 induced tff1 in the presence of 1 at 2 �M.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::982733b01d9199f0546d645d4946877e
https://doi.org/10.1158/1535-7163.22497384.v1
https://doi.org/10.1158/1535-7163.22497384.v1
Autor:
Peter B. Dervan, Jevgenij A. Raskatov, Benjamin C. Li, Amanda E. Hargrove, Jerzy O. Szablowski, Nicholas G. Nickols
PDF File - 24K, Serum concentrations of 1 after subcutaneous injection (120 nmol) into C57BL/6 mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277bbc3615dc79195d6debee5f3d92e5
https://doi.org/10.1158/1535-7163.22497381
https://doi.org/10.1158/1535-7163.22497381
Autor:
Peter B. Dervan, Jevgenij A. Raskatov, Benjamin C. Li, Amanda E. Hargrove, Jerzy O. Szablowski, Nicholas G. Nickols
PDF File - 43K, Comparison of cytotoxicity of 1 between T47D-KBLuc and ER-� negative cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f44011e3470d2f5a822eaab4d0fe12
https://doi.org/10.1158/1535-7163.22497387.v1
https://doi.org/10.1158/1535-7163.22497387.v1