LPS responsiveness and neutrophil chemotaxis in vivo require PMN MMP-8 activity.

Autor: Angus M Tester, Jennifer H Cox, Andrea R Connor, Amanda E Starr, Richard A Dean, Xose S Puente, Carlos López-Otín, Christopher M Overall

Publikováno v: PLoS ONE, Vol 2, Iss 3, p e312 (2007)

We identify matrix metalloproteinase (MMP)-8, the polymorphonuclear (PMN) leukocyte collagenase, as a critical mediator initiating lipopolysaccharide (LPS)-responsiveness in vivo. PMN infiltration towards LPS is abrogated in Mmp8-null mice. MMP-8 cle

Externí odkaz: https://doaj.org/article/43867c694e834ccb82d6c92d53dbe95f

Associations between Cellular Energy and Pediatric Inflammatory Bowel Disease Patient Response to Treatment

Autor: Shelley A. Deeke, Ruth Singleton, Joseph de Nanassy, Alain Stintzi, Eric I Benchimol, Zhibin Ning, Daniel Figeys, David R. Mack, Amanda E. Starr

Publikováno v: Journal of Proteome Research. 20:4393-4404

Inflammatory bowel diseases (IBDs), including Crohn's disease (CD) and ulcerative colitis, are chronic diseases of the gastrointestinal tract, with an unknown etiology, that affect over 6.8 million people worldwide. To characterize disease pathogenes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6785770bbc64527f37f65535e45260
https://doi.org/10.1021/acs.jproteome.1c00341

In Vitro Metabolic Labeling of Intestinal Microbiota for Quantitative Metaproteomics

Autor: Ruth Singleton, Rui Chen, Daniel Figeys, David R. Mack, Xu Zhang, Amanda E. Starr, Shelley A. Deeke, Alain Stintzi, Janice Mayne, Jennifer Li, Zhibin Ning, James Butcher

Publikováno v: Analytical Chemistry. 88:6120-6125

Intestinal microbiota is emerging as one of the key environmental factors influencing or causing the development of numerous human diseases. Metaproteomics can provide invaluable information on the functional activities of intestinal microbiota and o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1aa4590742756ef674b2d267cb5f1a79
https://doi.org/10.1021/acs.analchem.6b01412

Active site specificity profiling of the matrix metalloproteinase family: Proteomic identification of 4300 cleavage sites by nine MMPs explored with structural and synthetic peptide cleavage analyses

Autor: Charlotte J. Morrison, Ulrich Eckhard, Reinhild Kappelhoff, Pitter F. Huesgen, Oliver Schilling, Giada Marino, Yili Wang, Jennifer H. Cox, Theo Klein, David Rodríguez, Verena Goebeler, Christopher M. Overall, Georgina S. Butler, Philipp F. Lange, Ulrich auf dem Keller, Antoine Dufour, Amanda E. Starr, Caroline L. Bellac, Anna Prudova

Publikováno v: Matrix biology 49, 37-60 (2016). doi:10.1016/j.matbio.2015.09.003
Scopus
Matrix Biology, 49
RUO. Repositorio Institucional de la Universidad de Oviedo
instname

Secreted and membrane tethered matrix metalloproteinases (MMPs) are key homeostatic proteases regulating the extracellular signaling and structural matrix environment of cells and tissues. For drug targeting of proteases, selectivity for individual m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06ed2936e1a382ecf49f37e449bc6965
https://doi.org/10.1016/j.matbio.2015.09.003

β‐Estradiol results in a proprotein convertase subtilisin/kexin type 9‐dependent increase in low‐density lipoprotein receptor levels in human hepatic HuH7 cells

Autor: Thilina Dewpura, Janice Mayne, Valérie Lemieux, Daniel Figeys, Michel Chrétien, Angela Raymond, Jasmine I. Moore, Amanda E. Starr, Jenny Noad

Publikováno v: The Febs Journal

The lower risk of coronary artery disease in premenopausal women than in men and postmenopausal women implicates sex steroids in cardioprotective processes. β‐Estradiol upregulates liver low‐density lipoprotein receptor (LDLR), which, in turn, d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a90fc4e43d4eb02229683104045aaf5
https://doi.org/10.1111/febs.13309