Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Amanda Dombroski"'
Autor:
Christopher E. Arcadia, Eamonn Kennedy, Joseph Geiser, Amanda Dombroski, Kady Oakley, Shui-Ling Chen, Leonard Sprague, Mustafa Ozmen, Jason Sello, Peter M. Weber, Sherief Reda, Christopher Rose, Eunsuk Kim, Brenda M. Rubenstein, Jacob K. Rosenstein
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Small non-polymeric molecules have tremendous structural diversity that can be used to represent information. Here the authors encode data in synthesized libraries of Ugi products.
Externí odkaz:
https://doaj.org/article/92170d8dd04a47c6ae74a60e4d7c6756
Autor:
David W Morgens, Charlene Chan, Andrew J Kane, Nicholas R Weir, Amy Li, Michael M Dubreuil, C Kimberly Tsui, Gaelen T Hess, Adam Lavertu, Kyuho Han, Nicole Polyakov, Jing Zhou, Emma L Handy, Philip Alabi, Amanda Dombroski, David Yao, Russ B Altman, Jason K Sello, Vladimir Denic, Michael C Bassik
Publikováno v:
eLife, Vol 8 (2019)
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi
Externí odkaz:
https://doaj.org/article/f8b0b64eb9da49ff8b1b2ae4b6712fa1
Autor:
Kelsy Hennebarrows, Samantha Tuepker, Thomas Powell, Ronald B. Miller, Kristin Mount, Kimberly Allshouse, Jacob Rusczek, Michele Fouts, David O'Leary, Brian Ashley, Amanda Dombroski
Publikováno v:
Pragmatic Case Studies in Psychotherapy. 17:129-209
In 2011 our research group published a pilot study—the Case of "Anna"—employing the Panel of Psychological Inquiry (PPI) Clinical Case Study Method. The present study—the Case of "Ronan"—is a second example of the PPI method in action. The Ca
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d99fc01e9d1e940665dcb60b6e07c41
https://doi.org/10.14713/pcsp.v17i2.2095
https://doi.org/10.14713/pcsp.v17i2.2095
Autor:
Jacob K. Rosenstein, Eunsuk Kim, Christopher Rose, Amanda Dombroski, Sherief Reda, Kady Oakley, Shui Ling Chen, Christopher E. Arcadia, Hokchhay Tann, Brenda M. Rubenstein
Publikováno v:
Chemical Science
Autocatalysis is fundamental to many biological processes, and kinetic models of autocatalytic reactions have mathematical forms similar to activation functions used in artificial neural networks. Inspired by these similarities, we use an autocatalyt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eaef0e6bc817a7cfcdcca72a56132d9
http://europepmc.org/articles/PMC8179570
http://europepmc.org/articles/PMC8179570
Autor:
Ruth M. Colwill, Robbert Creton, Elizabeth S. Kahn, Danielle E. Clift, Peter Baek, Tania M. Dominguez-Gonzalez, Kerry Eller, Renee J. Seto, Sara K. Tucker, Robert J. Thorn, Amanda Dombroski, Jason K. Sello
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
Scientific Reports
Scientific Reports
Visual impairment affects 253 million people worldwide and new approaches for prevention and treatment are urgently needed. While small molecules with potential beneficial effects can be examined in various model systems, the in vivo evaluation of vi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61eeb177971ff2712b3a4e2518d61de3
http://link.springer.com/article/10.1038/s41598-019-50372-0
http://link.springer.com/article/10.1038/s41598-019-50372-0
Autor:
Amanda Dombroski, Eunsuk Kim, Christopher E. Arcadia, Shui Ling Chen, Christopher Rose, Brenda M. Rubenstein, Jacob K. Rosenstein, Sherief Reda, Kady Oakley, Farnaz Nouraei
Publikováno v:
Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences. 477
Chemical mixtures can be leveraged to store large amounts of data in a highly compact form and have the potential for massive scalability owing to the use of large-scale molecular libraries. With the parallelism that comes from having many species av
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2eb3ee427780263142db70bc33c30ed
https://doi.org/10.1098/rspa.2020.0899
https://doi.org/10.1098/rspa.2020.0899
Autor:
Jacob K. Rosenstein, Kady Oakley, Jason K. Sello, Amanda Dombroski, Leonard Sprague, Christopher Rose, Sherief Reda, Joseph Geiser, Shui-Ling Chen, Eunsuk Kim, Brenda M. Rubenstein, Eamonn Kennedy, Mustafa Ozmen, Christopher E. Arcadia, Peter M. Weber
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-8 (2020)
Multicomponent reactions enable the synthesis of large molecular libraries from relatively few inputs. This scalability has led to the broad adoption of these reactions by the pharmaceutical industry. Here, we employ the four-component Ugi reaction t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa56545e7baeae09860dcb30fea42b33
http://europepmc.org/articles/PMC7000828
http://europepmc.org/articles/PMC7000828
Autor:
Adam Lavertu, Nicholas R. Weir, Amanda Dombroski, Amy Li, Nicole J. Polyakov, David Yao, Vladimir Denic, Jing Zhou, Charlene Chan, Gaelen T. Hess, David W. Morgens, Kyuho Han, Andrew J Kane, Jason K. Sello, C. Kimberly Tsui, Michael M. Dubreuil, Russ B. Altman, Philip Alabi, Emma L. Handy, Michael C. Bassik
Publikováno v:
eLife, Vol 8 (2019)
eLife
eLife
The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b82cafeb61e78e78bd0b38dc89ac72c6
https://doi.org/10.7554/elife.48434
https://doi.org/10.7554/elife.48434
Autor:
Charlene Chan, Andrew J Kane, David W. Morgens, C. Kimberly Tsui, Amanda Dombroski, Amy Li, Nicholas R. Weir, Gaelen T. Hess, Russ B. Altman, Vladimir Denic, Jing Zhou, Emma L. Handy, Adam Lavertu, Jason K. Sello, Kyuho Han, Michael C. Bassik, Philip Alabi, Michael M. Dubreuil, David Yao, Nicole J. Polyakov
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdab76f48078f5cb90043821815d13a1
https://doi.org/10.7554/elife.48434.022
https://doi.org/10.7554/elife.48434.022
Autor:
Eamonn Kennedy, Shui Ling Chen, Amanda Dombroski, Peter M. Weber, Joseph Geiser, Christopher Rose, Kady Oakley, Brenda M. Rubenstein, Christopher E. Arcadia, Jacob K. Rosenstein, Sherief Reda, Hokchhay Tann, Eunsuk Kim, Jason K. Sello
Molecular data systems have the potential to store information at dramatically higher density than existing electronic media. Some of the first experimental demonstrations of this idea have used DNA, but nature also uses a wide diversity of smaller n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3734f7b52da85164aa74499935d49a
http://arxiv.org/abs/1905.02187
http://arxiv.org/abs/1905.02187