Maleimide–Thiol Linkages Alter the Biodistribution of SN38 Therapeutic Microbubbles Compared to Biotin–Avidin While Preserving Parity in Tumoral Drug Delivery

Autor: Nicola Ingram, Radwa H. Abou-Saleh, Amanda D. Race, Paul M. Loadman, Richard J. Bushby, Stephen D. Evans, P. Louise Coletta

Publikováno v: Pharmaceutics, Vol 16, Iss 3, p 434 (2024)

Therapeutic microbubbles (thMBs) contain drug-filled liposomes linked to microbubbles and targeted to vascular proteins. Upon the application of a destructive ultrasound trigger, drug uptake to tumour is improved. However, the structure of thMBs curr

Externí odkaz: https://doaj.org/article/abff952cecfb4e338f01079ea86da640

Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid

Autor: Milene Volpato, John Hutchinson, Catriona Marshall, P. Louise Coletta, Jade A. Spencer, Nicola Ingram, SL Perry, Anna Nicolaou, Paul M. Loadman, Mark A. Hull, Amanda D. Race

Publikováno v: Nicolaou, A & et al. 2020, ' Cyclooxygenase activity mediates colorectal cancer cell resistance to the omega-3 polyunsaturated fatty acid eicosapentaenoic acid ', Cancer Chemotherapy and Pharmacology . https://doi.org/10.1007/s00280-020-04157-2
Cancer Chemother Pharmacol
Cancer Chemotherapy and Pharmacology

PurposeThe naturally-occurring omega-3 polyunsaturated fatty acid eicosapentaenoic acid (EPA) is safe, well-tolerated and inexpensive, making it an attractive anti-cancer intervention. However, EPA has only modest anti-colorectal cancer (CRC) activit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de86493b213c066d2f4df5e4d849c186
https://doi.org/10.1007/s00280-020-04157-2

Abstract 4847: Optimizing the combination of the CDK4/6 inhibitor palbociclib and paclitaxel using cell cycle analysis

Autor: Jade A. Spencer, Paul M. Loadman, Patricia A. Cooper, Chris Twelves, Steven D. Shnyder, Amanda D. Race

Publikováno v: Cancer Research. 80:4847-4847

Background: Palbociclib is a CDK4/6 inhibitor approved for the treatment of ER+ HER2- advanced/metastatic breast cancer (MBC). We explored the hypothesis that palbociclib can enhance the efficacy of cytotoxics by synchronising the cell cycle prior to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fbad6c4298e3c86c8796f70151002dde
https://doi.org/10.1158/1538-7445.am2020-4847

Abstract 241: An efficient cell-based assay for quantification of cellular polysialic acid in neuroblastoma

Autor: Amanda D. Race, Xiaoxiao Guo, Robert A. Falconer, Paul M. Loadman, Goreti Ribeiro Morais, Jodie R. Malcolm, Steven D. Shnyder, Francis M. Barnieh, Laurence H. Patterson

Publikováno v: Cancer Research. 79:241-241

Introduction Polysialic acid (polySia) decorates the surface of NCAM (neuronal cell adhesion molecule) on neuroendocrine tumors, notably neuroblastoma and small cell lung cancer, and is strongly associated with poor prognosis and aggressive disease i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3e4beb8c7e0e1a1ed8e59064541ad0ee
https://doi.org/10.1158/1538-7445.am2019-241

A liquid chromatography-tandem mass spectrometry method to measure fatty acids in biological samples

Autor: Milene Volpato, Mark A. Hull, Alessandra Munarini, Andrew J. Cockbain, Jade A. Spencer, Andrea Belluzzi, Amanda D. Race, Paul M. Loadman

Publikováno v: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

As pre-clinical and clinical research interest in ω-3 polyunsaturated fatty acids (PUFA) increases, so does the need for a fast, accurate and reproducible analytical method to measure fatty acids (FA) in biological samples in order to validate poten

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46e26ddf201bd13aad3e790535ccc4d
https://pubmed.ncbi.nlm.nih.gov/28467947