Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Amanda D Yzaguirre"'
Autor:
Amanda D Yzaguirre, Arun Padmanabhan, Eric D de Groh, Kurt A Engleka, Jun Li, Nancy A Speck, Jonathan A Epstein
Publikováno v:
eLife, Vol 4 (2015)
Type I neurofibromatosis (NF1) is caused by mutations in the NF1 gene encoding neurofibromin. Neurofibromin exhibits Ras GTPase activating protein (Ras-GAP) activity that is thought to mediate cellular functions relevant to disease phenotypes. Loss o
Externí odkaz:
https://doaj.org/article/27d46286b9ea495bb6740aa413f93f2b
Autor:
Amanda D Yzaguirre, Carissa Dege, Daniel Sivalingam, Rahel Schnellmann, Alec Witty, Bahram Valamehr
Publikováno v:
Blood. 140:5728-5729
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f95c8c578127e5b4a7b59a3cc43e1c62
https://doi.org/10.1182/blood-2022-169989
https://doi.org/10.1182/blood-2022-169989
Autor:
Shahin Rafii, Amanda D. Yzaguirre, Bing He, Peng Gao, Kai Tan, Elizabeth D. Howell, Melike Lakadamyali, Nancy A. Speck, Raphael Lis
Publikováno v:
Genesdevelopment. 35(21-22)
Hematopoietic stem and progenitor cells (HSPCs) are generated de novo in the embryo from hemogenic endothelial cells (HECs) via an endothelial-to-hematopoietic transition (EHT) that requires the transcription factor RUNX1. Ectopic expression of RUNX1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d133ae1de97c26186507214641f1fce0
https://pubmed.ncbi.nlm.nih.gov/34675061
https://pubmed.ncbi.nlm.nih.gov/34675061
Autor:
Shohreh Sikaroodi, Bruce Walcheck, Yijia Pan, Amanda D. Yzaguirre, Martin Hosking, Soheila Shirinbak, Angela Gentile, Jianming Wu, Bahram Valamehr, Mochtar Pribadi, Joy Grant, Philip Chu, Amit R. Mehta, Wen-I Yeh, Anhco Nguyen
Publikováno v:
Cancer Research. 81:1497-1497
Although chimeric antigen receptor (CAR)-T cells have been transformational for several liquid tumors, their effectiveness in treating a variety of solid tumors has been limited in part because the heterogeneity of tumor-associated antigens found in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d672d37e5ae3be583d9edf057967475
https://doi.org/10.1158/1538-7445.am2021-1497
https://doi.org/10.1158/1538-7445.am2021-1497
Autor:
Amanda D. Yzaguirre, Nancy A. Speck
Publikováno v:
Developmental Dynamics. 245:1011-1028
Background Hematopoietic stem and progenitor cells (HSPCs) are generated de novo in the embryo in a process termed the endothelial to hematopoietic transition (EHT). EHT is most extensively studied in the yolk sac and dorsal aorta. Recently new sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::62ff57c39011b9f927ea314ffcbb7c2b
https://doi.org/10.1002/dvdy.24430
https://doi.org/10.1002/dvdy.24430
Autor:
Bahram Valamehr, Samuel LaBarge, Yi-Shin Lai, Mochtar Pribadi, Suzanna Gasparian, Mandal Mili, Alma Gutierrez, Matthew Denholtz, Gloria Hsia, Jason ORourke, May Sumi, Bi-Huei Yang, Cokey Nguyen, Sandeep Kothapally Hanok, Alec Witty, Eric Sung, Amit R. Mehta, Raedun Clarke, Ramzey Abujarour, Eigen Peralta, Emily Carron, Thomas H. Lee, Emily Driver, Angela Gentile, Natalie Navarrete, David J. Robbins, Wen-I Yeh, Philip Chu, Chia-Wei Chang, Amanda D. Yzaguirre
Publikováno v:
Blood. 136:11-11
The development of chimeric antigen receptor (CAR) T cell therapeutics is widely recognized as a significant advancement for the treatment of cancer. However, several obstacles currently impede the broad use of CAR T cells, including the inherent pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6d8f69cdaa6921660b3c4c80e2deffbb
https://doi.org/10.1182/blood-2020-138930
https://doi.org/10.1182/blood-2020-138930
Publikováno v:
Development.
Hematopoietic cells differentiate during embryogenesis from a population of endothelial cells called hemogenic endothelium (HE) in a process called the endothelial to hematopoietic transition (EHT). The transcription factor Runx1 is required for EHT,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8059b2185ef9a584f3aa4809cacd617f
https://doi.org/10.1242/dev.158162
https://doi.org/10.1242/dev.158162
Autor:
Amanda D. Yzaguirre, Andrea Ditadi, Gordon Keller, Xin Cheng, Christopher M. Sturgeon, Elizabeth Ng, Edouard G. Stanley, Geneve Awong, Lisa Azzola, Paul Gadue, Marion Kennedy, Deborah L. French, Joanna Tober, Nancy A. Speck, Andrew G. Elefanty
Publikováno v:
Nature cell biology
The generation of haematopoietic stem cells (HSCs) from human pluripotent stem cells (hPSCs) will depend on the accurate recapitulation of embryonic haematopoiesis. In the early embryo, HSCs develop from the haemogenic endothelium (HE) and are specif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d01820e993316ab09cd465d16744a13
https://doi.org/10.1038/ncb3161
https://doi.org/10.1038/ncb3161
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9789811032318
The de novo generation of hematopoietic stem and progenitor cells (HSPC) occurs solely during embryogenesis from a population of epithelial cells called hemogenic endothelium (HE). During midgestation HE cells in multiple intra- and extraembryonic va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25248a9968146a703e9e419edb4e589f
https://europepmc.org/articles/PMC5813695/
https://europepmc.org/articles/PMC5813695/
Autor:
Wanda Kwan, Isaura M. Frost, Mauricio Cortes, Kai Tan, Joanna Tober, Virginie Esain, Marijke W. Maijenburg, Trista E. North, Elaine Dzierzak, Xiongwei Cai, Nancy A. Speck, Stuart H. Orkin, Li Teng, Yan Li, Amanda D. Yzaguirre, Jian Xu
Publikováno v:
Genes & Development, 28(23), 2597-2612. Cold Spring Harbor Laboratory Press
Li, Y, Esain, V, Teng, L, Xu, J, Kwan, W, Frost, I M, Yzaguirre, A D, Cai, X, Cortes, M, Maijenburg, M W, Tober, J, Dzierzak, E, Orkin, S H, Tan, K, North, T E & Speck, N A 2014, ' Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production ', Genes & Development, vol. 28, no. 23, pp. 2597-612 . https://doi.org/10.1101/gad.253302.114
Li, Y, Esain, V, Teng, L, Xu, J, Kwan, W, Frost, I M, Yzaguirre, A D, Cai, X, Cortes, M, Maijenburg, M W, Tober, J, Dzierzak, E, Orkin, S H, Tan, K, North, T E & Speck, N A 2014, ' Inflammatory signaling regulates embryonic hematopoietic stem and progenitor cell production ', Genes & Development, vol. 28, no. 23, pp. 2597-612 . https://doi.org/10.1101/gad.253302.114
Identifying signaling pathways that regulate hematopoietic stem and progenitor cell (HSPC) formation in the embryo will guide efforts to produce and expand HSPCs ex vivo. Here we show that sterile tonic inflammatory signaling regulates embryonic HSPC
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bb54b0b85e4bc4dfd75ee02e25afbc6
https://doi.org/10.1101/gad.253302.114
https://doi.org/10.1101/gad.253302.114