Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Amanda Carette"'
Autor:
Kathryn Silva, Nicole Heise, Govind Bhagat, Ulf Klein, Nilushi S. De Silva, Fabiano Orelli, Maja Milanovic, Amanda Carette, Michael M Anderson
Publikováno v:
Immunology and cell biology
Signaling through the canonical nuclear factor‐κB (NF‐κB) pathway is critical for the generation and maintenance of mature B cells and for antigen‐dependent B‐cell activation. c‐REL (rel) and RELA (rela) are the downstream transcriptional
Autor:
Manolis Pasparakis, Ulf Klein, Kathryn Silva, Amanda Carette, Giorgia Simonetti, Nilushi S. De Silva, Nicole Heise
Publikováno v:
The Journal of Experimental Medicine
Heise et al. find that the NF-κB subunits c-REL and RELA in B cells play distinct roles during the germinal center reaction. While RELA stimulates the emergence of plasma cells from the germinal center, c-REL supports maintenance of the reaction ove
Autor:
Oliwia Rysnik, Soraya Hölper, Paul Bowness, E. Desogus, Alessandra Vacca, K McHugh, Alessandro Mathieu, Matteo Piga, P. Garau, Miguel Angel Blanco-Gelaz, Giorgio La Nasa, Jacqueline Shaw, Christoph Renner, A. Cauli, Joanna L. Giles, Sarah Fiedler, V. Ibba, Sravan Payeli, Simon Kollnberger, Hiroko Hatano, Giovanni Porru, Carlos López-Larrea, Amanda Carette, G. Dessole
Publikováno v:
Rheumatology. 52:1952-1962
Objectives. HLA-B*27:05 is associated with AS whereas HLA-B*27:09 is not associated. We hypothesized that different interactions with KIR immune receptors could contribute to the difference in disease association between HLA-B*27:05 and HLAB*27:09. T
Autor:
Govind Bhagat, Michael M Anderson, Nicole Heise, Nilushi S. De Silva, Amanda Carette, Ulf Klein, Kathryn Silva
The NF-κB signaling cascade relays external signals essential for B-cell growth and survival. This cascade is frequently hijacked by cancers that arise from the malignant transformation of germinal center (GC) B cells, underscoring the importance of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17da1c9472551f57ac6cbe5d18490224
Autor:
Tongwei Mo, Marie Lia, Hongyan Tang, Qiong Shen, Govind Bhagat, Amanda Carette, Ulf Klein, Riccardo Dalla-Favera
Publikováno v:
Blood. 119:2981-2990
Deletion of chromosomal region 13q14 represents the most common genetic aberration in B-cell chronic lymphocytic leukemia (CLL). 13q14 deletions are commonly large and heterogeneous in size and affect multiple genes. We recently found that targeted d
Autor:
Nicole Heise, Kathryn Silva, Nilushi S. De Silva, Giorgia Simonetti, Haowei Wang, Ulf Klein, Amanda Carette, Mark J. Shlomchik, Christian W. Siebel
Publikováno v:
The Journal of Experimental Medicine
The transcription factor IRF4 limits the retention of B cells in the marginal zone by inhibiting NOTCH2 signaling.
The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-ac
The transcription factor interferon regulatory factor-4 (IRF4) is expressed in B cells at most developmental stages. In antigen-ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b96483ee4ddd068ba8510a428b3513ff
http://hdl.handle.net/11585/395879
http://hdl.handle.net/11585/395879
Publikováno v:
Blood. 118:285-285
Abstract 285 Chronic lymphocytic leukemia (CLL) originates from the malignant transformation of mature B cells. Recently, single nucleotide polymorphisms (SNPs) in the 3'UTR region of the Irf4 gene have been associated with an increased risk of devel
Publikováno v:
Clinical Lymphoma Myeloma and Leukemia. 11:S168-S169
285 Chronic lymphocytic leukemia (CLL) originates from the malignant transformation of mature B cells. Recently, single nucleotide polymorphisms (SNPs) in the 39UTR region of the Irf4 gene have been associated with an increased risk of developing CLL
Autor:
Qiong Shen, Ulf Klein, Riccardo Dalla-Favera, Hongyan Tang, Govind Bhagat, Amanda Carette, Marie Lia, Tongwei Mo
Publikováno v:
Blood. 118:468-468
Abstract 468 Deletion of chromosomal region 13q14 represents the most common genetic aberration in chronic lymphocytic leukemia (CLL) and occurs with less frequency in other lymphoid malignancies. 13q14 deletions are commonly large and heterogeneous
Autor:
Nicole Heise, Govind Bhagat, Ulf Klein, Nilushi S. De Silva, Giorgia Simonetti, Amanda Carette
Publikováno v:
Blood. 118:216-216
Abstract 216 The majority of B cell-derived neoplasms, including Hodgkin and Non-Hodgkin lymphoma and multiple myeloma (MM), arise from antigen-specific B cells that have undergone the germinal center (GC) reaction of T-dependent immune responses. Re