Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Amanda Carbonell"'
Autor:
John A. Ligon, R. Taylor Sundby, Mary F. Wedekind, Fernanda I. Arnaldez, Jaydira Del Rivero, Lori Wiener, Ramaprasad Srinivasan, Melissa Spencer, Amanda Carbonell, Haiyan Lei, John Shern, Seth M. Steinberg, William D. Figg, Cody J. Peer, Sara Zimmerman, Josquin Moraly, Xia Xu, Stephen Fox, King Chan, Michael I. Barbato, Thorkell Andresson, Naomi Taylor, Karel Pacak, J. Keith Killian, Eva Dombi, W. Marston Linehan, Markku Miettinen, Richard Piekarz, Lee J. Helman, Paul Meltzer, Brigitte Widemann, John Glod
Publikováno v:
Clinical Cancer Research. 29:341-348
Purpose: Succinate dehydrogenase (dSDH)-deficient tumors, including pheochromocytoma/paraganglioma, hereditary leiomyomatosis and renal cell cancer–associated renal cell carcinoma (HLRCC-RCC), and gastrointestinal stromal tumors (GIST) without KIT
Autor:
John Glod, Brigitte Widemann, Paul Meltzer, Lee J. Helman, Richard Piekarz, Markku Miettinen, W. Marston Linehan, Eva Dombi, J. Keith Killian, Karel Pacak, Naomi Taylor, Thorkell Andresson, Michael I. Barbato, King Chan, Stephen Fox, Xia Xu, Josquin Moraly, Sara Zimmerman, Cody J. Peer, William D. Figg, Seth M. Steinberg, John Shern, Haiyan Lei, Amanda Carbonell, Melissa Spencer, Ramaprasad Srinivasan, Lori Wiener, Jaydira Del Rivero, Fernanda I. Arnaldez, Mary F. Wedekind, R. Taylor Sundby, John A. Ligon
Supplemental methods and figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f4aed425377725c030715bc2ebb784b
https://doi.org/10.1158/1078-0432.22488915
https://doi.org/10.1158/1078-0432.22488915
Autor:
John Glod, Brigitte Widemann, Paul Meltzer, Lee J. Helman, Richard Piekarz, Markku Miettinen, W. Marston Linehan, Eva Dombi, J. Keith Killian, Karel Pacak, Naomi Taylor, Thorkell Andresson, Michael I. Barbato, King Chan, Stephen Fox, Xia Xu, Josquin Moraly, Sara Zimmerman, Cody J. Peer, William D. Figg, Seth M. Steinberg, John Shern, Haiyan Lei, Amanda Carbonell, Melissa Spencer, Ramaprasad Srinivasan, Lori Wiener, Jaydira Del Rivero, Fernanda I. Arnaldez, Mary F. Wedekind, R. Taylor Sundby, John A. Ligon
Purpose:Succinate dehydrogenase (dSDH)-deficient tumors, including pheochromocytoma/paraganglioma, hereditary leiomyomatosis and renal cell cancer–associated renal cell carcinoma (HLRCC-RCC), and gastrointestinal stromal tumors (GIST) without KIT o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef116342f2e7372276d518283c2932f4
https://doi.org/10.1158/1078-0432.c.6532833
https://doi.org/10.1158/1078-0432.c.6532833
Autor:
William D. Figg, Jaishri O. Blakeley, Andrea M. Gross, Oxana Borisovna Kapustina, John Glod, Andrea Baldwin, Janet Therrien, Brigitte C. Widemann, Amanda Carbonell, Seth M. Steinberg, Eva Dombi, Staci Martin, Kara Heisey, D. Wade Clapp, Dominique C. Pichard, Brian Weiss, L. Austin Doyle, Scott M. Paul, Marie Claire Roderick, Amish C. Shah, David Venzon, Malcolm A. Smith, Miriam Bornhorst, Patricia Whitcomb, Ae Rang Kim, Pamela L. Wolters, Chi Zhang, Cody J. Peer, Michael Fisher
Publikováno v:
New England Journal of Medicine. 382:1430-1442
No approved therapies exist for inoperable plexiform neurofibromas in patients with neurofibromatosis type 1.We conducted an open-label, phase 2 trial of selumetinib to determine the objective response rate among patients with plexiform neurofibromas
Autor:
Jaydira Del Rivero, Brigitte C. Widemann, Amanda Carbonell, Prashant Chittiboina, Maran Ilanchezhian, Reinier Alvarez
Von Hippel-Lindau disease is an inherited, autosomal dominant tumor predisposition syndrome which leads to susceptibility for developing hemangioblastomas of the central nervous system and retina, as well as other tumor types. No approved systemic th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::27782bd398d50c5ebbc4a9f0ba726f6f
https://doi.org/10.21203/rs.3.rs-330233/v1
https://doi.org/10.21203/rs.3.rs-330233/v1
Autor:
Jennifer Desanto, Geraldine O'Sullivan, Cecilia Tibery, Eva Dombi, Joanne Derdak, Kaleb Yohay, Sadhana Jackson, Patricia Whitcomb, Brigitte C. Widemann, Eva H. Baker, Andrea Baldwin, Alice P. Chen, Amanda Carbonell, Andrea M. Gross
Publikováno v:
Neurooncol Adv
Background Spinal neurofibromas (SNFs) in neurofibromatosis type 1 (NF1) can cause progressive spinal cord compression and neurological dysfunction. The MEK inhibitor selumetinib shrinks the majority of plexiform neurofibromas (PNs) in patients with
Autor:
Bradford J. Wood, Cecilia Tibery, Joanne Derdak, William Herrick, Jeevan P Govindharajulu, Dominique C. Pichard, Geraldine O'Sullivan Coyne, Jennifer Desanto, Eva Dombi, Andrea M. Gross, Apurva K. Srivastava, Alice P. Chen, Brigitte C. Widemann, James H. Doroshow, Lawrence A. Doyle, Casey L. Kilpatrick, Ralph E. Parchment, Amanda Carbonell
Publikováno v:
Cancer Research. 80:805-805
Background: The oral MEK 1/2 inhibitor selumetinib (50-mg po, BID) has shown remarkable response rates in an ongoing phase-II trial (NCT02407405) in adult patients (pts) with neurofibromatosis type-1 (NF1) (cutaneous neurofibroma (cNF) or inoperable
Autor:
Larry Rubinstein, Patricia Whitcomb, Andrea M. Gross, Eva Dombi, Cecilia Tibery, Dominique C. Pichard, Joanne Derdak, Apurva K. Srivastava, William Herrick, James H. Doroshow, Pamela L. Wolters, Amanda Carbonell, Naoko Takebe, Staci Martin, Alice P. Chen, Ralph E. Parchment, Geraldine O'Sullivan Coyne, Brigitte C. Widemann
Publikováno v:
Journal of Clinical Oncology. 38:3612-3612
3612 Background: NF1-related PN are locally invasive tumors characterized by increased activation of the RAS pathway causing significant morbidity including disfigurement, pain and functional limitations. Selumetinib has received breakthrough designa
Autor:
Alex Telionis, Kevin Lahmers, Michelle Todd, Amanda Carbonello, Charles C. Broaddus, Carolynn J. Bissett, Laura L. Hungerford
Publikováno v:
Pathogens, Vol 11, Iss 11, p 1353 (2022)
Theileria orientalis, genotype Ikeda, was recently detected in North America. Determining the emerging distribution of this pathogen is critical for understanding spread and developing management strategies. Whole blood samples were collected from ca
Externí odkaz:
https://doaj.org/article/83d68a039dce4c89816b5dc841a24416