Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Amanda C. Sharko"'
Autor:
Amanda C. Sharko, Chang-Uk Lim, Martina S. J. McDermott, Chuck Hennes, Kingsavanh P. Philavong, Tiffanie Aiken, Victor V. Tatarskiy, Igor B. Roninson, Eugenia V. Broude
Publikováno v:
Cells, Vol 10, Iss 1, p 144 (2021)
Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequen
Externí odkaz:
https://doaj.org/article/c8a8be021b1e434fad24bdd39e2993bd
Autor:
Martina S.J. McDermott, Amanda C. Sharko, Jessica Munie, Susannah Kassler, Theresa Melendez, Chang-uk Lim, Eugenia V. Broude
Publikováno v:
Cells, Vol 9, Iss 3, p 638 (2020)
CDK7, a transcriptional cyclin-dependent kinase, is emerging as a novel cancer target. Triple-negative breast cancers (TNBC) but not estrogen receptor-positive (ER+) breast cancers have been reported to be uniquely sensitive to the CDK7 inhibitor THZ
Externí odkaz:
https://doaj.org/article/64799c7355f84d01997e8616e6544aba
Autor:
Xiaokai Ding, Hao Ji, Amanda C. Sharko, Juergen Loskutov, Zachary Mack, Jadyn Myers, Mengqian Chen, Elena Pugacheva, Igor Roninson, Eugenia Broude
Publikováno v:
Cancer Research. 83:PD5-10
Triple negative breast cancer (TNBC) is the most aggressive subtype of all breast cancers. However, unlike other breast cancer subtypes, current treatments for TNBC are restricted and this scarcity of viable options is the key contributor to the poor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee2e708442d3d04c65604d9ab39bc205
https://doi.org/10.1158/1538-7445.sabcs22-pd5-10
https://doi.org/10.1158/1538-7445.sabcs22-pd5-10
Autor:
Xiaokai Ding, Amanda C. Sharko, Martina S. J. McDermott, Gary P. Schools, Alexander Chumanevich, Hao Ji, Jing Li, Li Zhang, Zachary T. Mack, Vitali Sikirzhytski, Michael Shtutman, Laura Ivers, Norma O’Donovan, John Crown, Balázs Győrffy, Mengqian Chen, Igor B. Roninson, Eugenia V. Broude
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Breast cancers (BrCas) that overexpress oncogenic tyrosine kinase receptor HER2 are treated with HER2-targeting antibodies (such as trastuzumab) or small-molecule kinase inhibitors (such as lapatinib). However, most patients with metastatic HER2+BrCa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::640ca8c9a7646d6a2b9c98f13fb056ee
https://doi.org/10.1073/pnas.2201073119
https://doi.org/10.1073/pnas.2201073119
Autor:
Eugenia V. Broude, Michael Shtutman, Xiaokai Ding, Zachary T. Mack, Igor B. Roninson, Mengqian Chen, Alexander A. Chumanevich, Hao Ji, Elena N. Pugacheva, Anastasia Khrustaleva, Martina McDermott, Alexander V. Tyakht, Victor V. Tatarskiy, Gary P. Schools, Amanda C. Sharko
Publikováno v:
Cancer Research. 81:LB132-LB132
One of every five breast cancers are driven by gene amplification and overexpression of HER2/ERBB2 tyrosine kinase. HER2+ breast cancers are treated both by monoclonal antibodies (such as trastuzumab) and small-molecule HER2 kinase inhibitors (such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9e59c2a6ce26404e986bfb5047d52626
https://doi.org/10.1158/1538-7445.am2021-lb132
https://doi.org/10.1158/1538-7445.am2021-lb132
Autor:
Chuck Hennes, Tiffanie Aiken, Martina McDermott, Victor V. Tatarskiy, Eugenia V. Broude, Kingsavanh P Philavong, Amanda C. Sharko, Chang-uk Lim, Igor B. Roninson
Publikováno v:
Cells
Volume 10
Issue 1
Cells, Vol 10, Iss 144, p 144 (2021)
Volume 10
Issue 1
Cells, Vol 10, Iss 144, p 144 (2021)
Drug resistance is the main obstacle to achieving cures with both conventional and targeted anticancer drugs. The emergence of acquired drug resistance is initially mediated by non-genetic transcriptional changes, which occur at a much higher frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad58f687281274daa6ef07a62ac3e684
https://doi.org/10.3390/cells10010144
https://doi.org/10.3390/cells10010144
Autor:
Jeffrey Parilla-Carrero, Marlene A. Wilson, Jim R. Fadel, Amanda C. Sharko, Kris F. Kaigler, Elisabeth M. Oliver, Ryan K. Butler
Publikováno v:
Behavioural Brain Research. 304:92-101
Rats exposed to the odor of a predator or to the elevated plus maze (EPM) express unique unconditioned fear behaviors. The extended amygdala has previously been demonstrated to mediate the response to both predator odor and the EPM. We seek to determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc8971cdab424842412dcf950d2eb3c
https://doi.org/10.1016/j.bbr.2016.01.051
https://doi.org/10.1016/j.bbr.2016.01.051
Autor:
Amanda C. Sharko, Theresa Melendez, Jessica Munie, Eugenia V. Broude, Susannah Kassler, Martina McDermott, Chang-uk Lim
Publikováno v:
Cells
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 638 (2020)
Volume 9
Issue 3
Cells, Vol 9, Iss 3, p 638 (2020)
CDK7, a transcriptional cyclin-dependent kinase, is emerging as a novel cancer target. Triple-negative breast cancers (TNBC) but not estrogen receptor-positive (ER+) breast cancers have been reported to be uniquely sensitive to the CDK7 inhibitor THZ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::deba5a240890e4068ae5a578447b48fc
https://doi.org/10.3390/cells9030638
https://doi.org/10.3390/cells9030638
Identifying the neurobiological mechanisms that underlie differential sensitivity to stress is critical for understanding the development and expression of stress-induced disorders, such as post-traumatic stress disorder (PTSD). Preclinical studies h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92412e08477269e61eb52bfe9a88245c
https://europepmc.org/articles/PMC5391308/
https://europepmc.org/articles/PMC5391308/
Autor:
Sara Faccidomo, Julie J. M. Grondin, Reginald Cannady, Amanda C. Sharko, Joyce Besheer, Clyde W. Hodge
Publikováno v:
Biological Psychiatry. 67:812-822
Background Systemic modulation of Group I and II metabotropic glutamate receptors (mGluRs) regulate ethanol self-administration in a variety of animal models. Although these receptors are expressed in reward-related brain regions, the anatomical spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5ce3158b8c5af1217f6304eb0ac5730
https://doi.org/10.1016/j.biopsych.2009.09.016
https://doi.org/10.1016/j.biopsych.2009.09.016