Výsledky vyhledávání - "Amanda C Stanley"

Akademický článek

Phase Ib open-label, multicenter study of pixatimod, an activator of TLR9, in combination with nivolumab in subjects with microsatellite-stable metastatic colorectal cancer, metastatic pancreatic ductal adenocarcinoma and other solid tumors

Autor: Matthew Burge, David Goldstein, Andrew Haydon, Nick Pavlakis, Charlotte Lemech, Edward Hammond, Darryn Bampton, Keith Dredge, Michael P Brown, Andrew Clouston, Nigel J Waterhouse, Amanda C Stanley, Lucie Leveque-El Mouttie, Grace M Chojnowski

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 11, Iss 1 (2023)

Background Pixatimod is a unique activator of the Toll-like Receptor 9 pathway. This phase I trial evaluated safety, efficacy and pharmacodynamics of pixatimod and PD-1 inhibitor nivolumab in immunologically cold cancers.Methods 3+3 dose escalation w

Externí odkaz: https://doaj.org/article/9084358ebd5841eb853afac834f15155

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Akademický článek

Rab6a/a' are important Golgi regulators of pro-inflammatory TNF secretion in macrophages.

Autor: Massimo Micaroni, Amanda C Stanley, Tatiana Khromykh, Juliana Venturato, Colin X F Wong, Jet P Lim, Brad J Marsh, Brian Storrie, Paul A Gleeson, Jennifer L Stow

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57034 (2013)

Lipopolysaccharide (LPS)-activated macrophages secrete pro-inflammatory cytokines, including tumor necrosis factor (TNF) to elicit innate immune responses. Secretion of these cytokines is also a major contributing factor in chronic inflammatory disea

Externí odkaz: https://doaj.org/article/8108c025746643c7a50056c597860b10

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Akademický článek

Caveolin-1 deficiency leads to increased susceptibility to cell death and fibrosis in white adipose tissue: characterization of a lipodystrophic model.

Autor: Sally Martin, Manuel A Fernandez-Rojo, Amanda C Stanley, Michele Bastiani, Satomi Okano, Susan J Nixon, Gethin Thomas, Jennifer L Stow, Robert G Parton

Publikováno v: PLoS ONE, Vol 7, Iss 9, p e46242 (2012)

Caveolin-1 (CAV1) is an important regulator of adipose tissue homeostasis. In the present study we examined the impact of CAV1 deficiency on the properties of mouse adipose tissue both in vivo and in explant cultures during conditions of metabolic st

Externí odkaz: https://doaj.org/article/ebdfa0414c6548d086faa36ff88e38fa

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Akademický článek

Critical roles for LIGHT and its receptors in generating T cell-mediated immunity during Leishmania donovani infection.

Autor: Amanda C Stanley, Fabian de Labastida Rivera, Ashraful Haque, Meru Sheel, Yonghong Zhou, Fiona H Amante, Patrick T Bunn, Louise M Randall, Klaus Pfeffer, Stefanie Scheu, Michael J Hickey, Bernadette M Saunders, Carl Ware, Geoff R Hill, Koji Tamada, Paul M Kaye, Christian R Engwerda

Publikováno v: PLoS Pathogens, Vol 7, Iss 10, p e1002279 (2011)

LIGHT (TNFSF14) is a member of the TNF superfamily involved in inflammation and defence against infection. LIGHT signals via two cell-bound receptors; herpes virus entry mediator (HVEM) and lymphotoxin-beta receptor (LTβR). We found that LIGHT is cr

Externí odkaz: https://doaj.org/article/5ef640afe72a44c3a61d67b9da4bb5dc

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Akademický článek

VCAM-1 and VLA-4 modulate dendritic cell IL-12p40 production in experimental visceral leishmaniasis.

Autor: Amanda C Stanley, Jane E Dalton, Susanna H Rossotti, Kelli P MacDonald, Yonghong Zhou, Fabian Rivera, Wayne A Schroder, Asher Maroof, Geoff R Hill, Paul M Kaye, Christian R Engwerda

Publikováno v: PLoS Pathogens, Vol 4, Iss 9, p e1000158 (2008)

Vascular cell adhesion molecule-1 (VCAM-1) interacts with its major ligand very late antigen-4 (VLA-4) to mediate cell adhesion and transendothelial migration of leukocytes. We report an important role for VCAM-1/VLA-4 interactions in the generation

Externí odkaz: https://doaj.org/article/b2afe5d6ed194f6fba89355169e91596

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Akademický článek

Activation of invariant NKT cells exacerbates experimental visceral leishmaniasis.

Autor: Amanda C Stanley, Yonghong Zhou, Fiona H Amante, Louise M Randall, Ashraful Haque, Daniel G Pellicci, Geoff R Hill, Mark J Smyth, Dale I Godfrey, Christian R Engwerda

Publikováno v: PLoS Pathogens, Vol 4, Iss 2, p e1000028 (2008)

We report that natural killer T (NKT) cells play only a minor physiological role in protection from Leishmania donovani infection in C57BL/6 mice. Furthermore, attempts at therapeutic activation of invariant NKT (iNKT) cells with alpha-galactosylcera

Externí odkaz: https://doaj.org/article/e0c2b08e0f7f41aa8e2178719d7a3681

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Interleukin-1β Maturation Triggers Its Relocation to the Plasma Membrane for Gasdermin-D-Dependent and -Independent Secretion

Autor: Ronan Kapetanovic, Darren L. Brown, Matthew J. Sweet, Dave Boucher, Caroline L. Holley, Jelena S. Bezbradica, Jennifer L. Stow, Kate Schroder, Kaiwen W. Chen, Verena Rolfes, Amanda C. Stanley, Mercedes Monteleone, Jessica B. von Pein, Melanie R. Shakespear

Publikováno v: Cell Reports, Vol 24, Iss 6, Pp 1425-1433 (2018)
Cell Reports, vol. 24, no. 6, pp. 1425-1433

Summary: IL-1β requires processing by caspase-1 to generate the active, pro-inflammatory cytokine. Acute IL-1β secretion from inflammasome-activated macrophages requires caspase-1-dependent GSDMD cleavage, which also induces pyroptosis. Mechanisms

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bd0f4467b87a32af873789ac3b7a3a9
https://doi.org/10.1016/j.celrep.2018.07.027

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340 A phase Ib study of the safety and tolerability of pixatimod plus nivolumab in subjects with advanced solid tumors with an expansion cohort in metastatic pancreatic adenocarcinoma (mPDAC)

Autor: Michael C. Brown, Nick Pavlakis, Matthew Burge, Lucie Leveque-ElMouttie, Grace Chojnowski, David Goldstein, Darryn Bampton, Andrew Haydon, Charlotte Lemech, Edward Hammond, Keith Dredge, Amanda C. Stanley

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundPixatimod is a novel immunomodulatory agent which stimulates dendritic cells (DC) via Toll-Like Receptor (TLR9) pathway to activate natural killer (NK) cells.1 In combination with PD1 inhibitors, it also enhances T cell infiltration in vivo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c14e56cc82386975bb836a4a01dcc122
https://doi.org/10.1136/jitc-2021-sitc2021.340

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341 A phase Ib expansion cohort of pixatimod plus nivolumab in previously treated, microsatellite stable metastatic colorectal cancer (MSS mCRC)

Autor: Amanda C. Stanley, Darryn Bampton, Andrew Clouson, Nick Pavlakis, Charlotte Lemech, Keith Dredge, Matthew Burge, Nigel J. Waterhouse, David Goldstein, Andrew Haydon, Lucie Leveque-ElMouttie, Grace Chojnowski, Michael P. Brown, Edward Hammond

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)

BackgroundPixatimod is a novel immunomodulatory agent which stimulates dendritic cells (DC) via Toll-Like Receptor 9 (TLR9) pathway to activate natural killer (NK) cells.1 It also enhances T cell infiltration into tumors when combined with PD1 inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a98d23ac214c89f86bd2d404cf330d5
https://doi.org/10.1136/jitc-2021-sitc2021.341

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