Zobrazeno 1 - 10
of 43
pro vyhledávání: '"Amanda C Smith"'
Publikováno v:
BMJ Global Health, Vol 9, Iss 8 (2024)
Introduction Chlamydia trachomatis (Ct) and Neisseria gonorrhoeae (Ng) infections are often asymptomatic; screening increases early detection and prevents disease, sequelae and further spread. To increase Ct and Ng testing, several countries have imp
Externí odkaz:
https://doaj.org/article/82e1ef5226354ebfad8a327be5679bde
Publikováno v:
Frontiers in Fungal Biology, Vol 3 (2022)
Baseline ploidy significantly impacts evolutionary trajectories and, specifically, tetraploidy is associated with higher rates of adaptation relative to haploidy and diploidy. While the majority of experimental evolution studies investigating ploidy
Externí odkaz:
https://doaj.org/article/705afd34bff24c898d2648af24b399a5
Publikováno v:
Frontiers in Fungal Biology, Vol 3 (2022)
Candida albicans is an opportunistic fungal pathogen of humans, yet the within-host dynamics of C. albicans infection are not clear. While C. albicans is commonly diploid, it exhibits a range of ploidies, including tetraploidy. Previous work found th
Externí odkaz:
https://doaj.org/article/84211b5cc2f34a4dab748e5ac46a67d6
Autor:
Amanda C. Smith, Meleah A. Hickman
Publikováno v:
mSphere, Vol 5, Iss 3 (2020)
ABSTRACT Candida albicans is an opportunistic fungal pathogen of humans that is typically diploid yet has a highly labile genome tolerant of large-scale perturbations including chromosomal aneuploidy and loss-of-heterozygosity events. The ability to
Externí odkaz:
https://doaj.org/article/3409c403985d4e2bb9f246e8a263d11b
Autor:
Kathleen Anne Bell, Raymond Kim, Melyssa Aronson, Brittany Gillies, Arif Ali Awan, Kathy Chun, Jennifer Hart, Rachel Healey, Linda Kim, Goran Klaric, Karen Panabaker, Peter J B Sabatini, Bekim Sadikovic, Shamini Selvarajah, Amanda C Smith, Tracy L Stockley, Andrea K Vaags, Andrea Eisen, Aaron Pollett, Harriet Feilotter
Publikováno v:
Journal of medical genetics.
BackgroundGenetic testing for hereditary cancer susceptibility has advanced over time due to the discovery of new risk genes, improved technology and decreased cost. In the province of Ontario, testing eligibility criteria were initially developed to
Autor:
Michelle M. Axford, Ron Agatep, Marcos Clavier, Stacey Hume, Elizabeth Spriggs, Andrea K Vaags, George S. Charames, Harriet Feilotter, Nicholas A. Watkins, Amanda C. Smith, Tracy Tucker, Matthew S. Lebo, Vanessa Di Gioacchino, Jordan Lerner-Ellis, Ian Bosdet, Mohammad R. Akbari, William D. Foulkes, Chloe Mighton, Sean S. Young, Lorena Lazo de la Vega, Talia Silver, Ryan E. Lamont, Laura Semenuk, Robert Tomaszewski, Christian R. Marshall, Nancy Hamel, Justin Mayers, Henry K. Wong, Jillian S. Parboosingh, Marsha Speevak, Aly Karsan, George Chong, Sherryl Taylor
Publikováno v:
J Med Genet
BackgroundThis study aimed to identify and resolve discordant variant interpretations across clinical molecular genetic laboratories through the Canadian Open Genetics Repository (COGR), an online collaborative effort for variant sharing and interpre
Publikováno v:
Infect Immun
The ability to generate genetic variation facilitates rapid adaptation in stressful environments. The opportunistic fungal pathogen Candida albicans frequently undergoes large-scale genomic changes, including aneuploidy and loss of heterozygosity (LO
Publikováno v:
Journal of visualized experiments : JoVE. (171)
While pathogens can be deadly to humans, many of them cause a range of infection types with non-lethal phenotypes. Candida albicans, an opportunistic fungal pathogen of humans, is the fourth most common cause of nosocomial infections which results in
Publikováno v:
Journal of Visualized Experiments.
While pathogens can be deadly to humans, many of them cause a range of infection types with non-lethal phenotypes. Candida albicans, an opportunistic fungal pathogen of humans, is the fourth most common cause of nosocomial infections which results in
Autor:
D Lahey, Gabrielle Mettler, Hussein Daoud, Nasim Vasli, Nathaniel Santos, Brittany Antoniuk, Caitlin Chisholm, Shelley Ordorica, Jean McGowan-Jordan, Vanessa Trudel, Amanda C. Smith, Olga Jarinova, Virginia Haslett, Heather Derksen, Mahdi Ghani, Landry Nfonsam, Robert Roberts, Ryan Potter, Martha McGill, Elizabeth Sinclair-Bourque
Publikováno v:
The Journal of Molecular Diagnostics. 21:437-448
Inherited cardiomyopathies (ICs) are a major cause of heart disease. Given their marked clinical and genetic heterogeneity, the content and clinical utility of IC multi-gene panels has been the topic of continuous debate. Our genetics diagnostic labo