Zobrazeno 1 - 10
of 74
pro vyhledávání: '"Amanda C Poholek"'
Autor:
Aaron Yang, Amanda C. Poholek
Publikováno v:
npj Systems Biology and Applications, Vol 10, Iss 1, Pp 1-8 (2024)
Abstract T cells are dynamically regulated immune cells that are implicated in a variety of diseases ranging from infection, cancer and autoimmunity. Recent advancements in sequencing methods have provided valuable insights in the transcriptional and
Externí odkaz:
https://doaj.org/article/cc87aab288c940c4a4fedacbc73876f0
Autor:
Pengcheng Shang, Joshua D. Simpson, Gwen M. Taylor, Danica M. Sutherland, Olivia L. Welsh, Pavithra Aravamudhan, Rita Dos Santos Natividade, Kristina Schwab, Joshua J. Michel, Amanda C. Poholek, Yijen Wu, Dhivyaa Rajasundaram, Melanie Koehler, David Alsteens, Terence S. Dermody
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Mammalian orthoreovirus (reovirus) infects most mammals and is associated with celiac disease in humans. In mice, reovirus infects the intestine and disseminates systemically to cause serotype-specific patterns of disease in the brain. To id
Externí odkaz:
https://doaj.org/article/3daf5306cc154b38afd87eb89709065d
Autor:
Ansen H.P. Burr, Junyi Ji, Kadir Ozler, Heather L. Mentrup, Onur Eskiocak, Brian Yueh, Rachel Cumberland, Ashley V. Menk, Natalie Rittenhouse, Chris W. Marshall, Pailin Chiaranunt, Xiaoyi Zhang, Lauren Mullinax, Abigail Overacre-Delgoffe, Vaughn S. Cooper, Amanda C. Poholek, Greg M. Delgoffe, Kevin P. Mollen, Semir Beyaz, Timothy W. Hand
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 16, Iss 2, Pp 287-316 (2023)
Background & Aims: The colonic epithelium requires continuous renewal by crypt resident intestinal stem cells (ISCs) and transit-amplifying (TA) cells to maintain barrier integrity, especially after inflammatory damage. The diet of high-income countr
Externí odkaz:
https://doaj.org/article/7bf9e1fb153c49e8aba512ab5a426106
IL-33 acts as a costimulatory signal to generate alloreactive Th1 cells in graft-versus-host disease
Autor:
Gaelen K. Dwyer, Lisa R. Mathews, José A. Villegas, Anna Lucas, Anne Gonzalez de Peredo, Bruce R. Blazar, Jean-Philippe Girard, Amanda C. Poholek, Sanjiv A. Luther, Warren Shlomchik, Hēth R. Turnquist
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 12 (2022)
Antigen-presenting cells (APCs) integrate signals emanating from local pathology and program appropriate T cell responses. In allogeneic hematopoietic stem cell transplantation (alloHCT), recipient conditioning releases damage-associated molecular pa
Externí odkaz:
https://doaj.org/article/79d274cbbf384598a5e3943e8a19aee2
Autor:
B. Rhodes Ford, Amanda C. Poholek
Publikováno v:
The Journal of Immunology. 210:869-879
Exhaustion is a state of CD8 T cell differentiation that occurs in settings of chronic Ag such as tumors, chronic viral infection, and autoimmunity. Cellular differentiation is driven by a series of environmental signals that promote epigenetic lands
Autor:
Lisa Y. Beppu, Raja Gopal Reddy Mooli, Xiaoyao Qu, Giovanni J. Marrero, Christopher A. Finley, Allen N. Fooks, Zachary P. Mullen, Adolfo B. Frias Jr., Ian Sipula, Bingxian Xie, Katherine E. Helfrich, Simon C. Watkins, Amanda C. Poholek, Sadeesh K. Ramakrishnan, Michael J. Jurczak, Louise M. D’Cruz
Publikováno v:
JCI Insight, Vol 6, Iss 3 (2021)
Interleukin-10 (IL-10) is a critical cytokine used by immune cells to suppress inflammation. Paradoxically, immune cell–derived IL-10 can drive insulin resistance in obesity by suppressing adipocyte energy expenditure and thermogenesis. However, th
Externí odkaz:
https://doaj.org/article/9126b15b09d845f0ae956d6a926c8723
Autor:
Aaron Yang, Amanda C. Poholek
Publikováno v:
Immunity. 56:895-897
Autor:
Paolo D. A. Vignali, Kristin DePeaux, McLane J. Watson, Chenxian Ye, B. Rhodes Ford, Konstantinos Lontos, Nicole K. McGaa, Nicole E. Scharping, Ashley V. Menk, Simon C. Robson, Amanda C. Poholek, Dayana B. Rivadeneira, Greg M. Delgoffe
Publikováno v:
Nature Immunology. 24:267-279
Autor:
Hyun Jung Park, Zhenjiang Fan, Yulong Bai, Qidong Ren, Youssef Rbaibi, Kimberly R. Long, Megan L. Gliozzi, Natalie Rittenhouse, Joseph D. Locker, Amanda C. Poholek, Ora A. Weisz
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Cultured cell models are an essential complement to dissecting kidney proximal tubule (PT) function in health and disease but do not fully recapitulate key features of this nephron segment. We recently determined that culture of opossum kidney (OK) c
Externí odkaz:
https://doaj.org/article/13f16484c8434e7fb674bdf16f980481
Autor:
Shankar Revu, Jing Wu, Matthew Henkel, Natalie Rittenhouse, Ashley Menk, Greg M. Delgoffe, Amanda C. Poholek, Mandy J. McGeachy
Publikováno v:
Cell Reports, Vol 22, Iss 10, Pp 2642-2653 (2018)
Summary: Th17 cells drive autoimmune disease but also control commensal microbes. A common link among antigens from self-proteins or commensal microbiota is relatively low activation of T cell receptor (TCR) and costimulation signaling. Indeed, stron
Externí odkaz:
https://doaj.org/article/ccc4f882024b4e13883ca1100600cc92