Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Amanda Burnett"'
Autor:
Ingrid Gomez, Ben Ward, Celine Souilhol, Chiara Recarti, Mark Ariaans, Jessica Johnston, Amanda Burnett, Marwa Mahmoud, Le Anh Luong, Laura West, Merete Long, Sion Parry, Rachel Woods, Carl Hulston, Birke Benedikter, Chiara Niespolo, Rohit Bazaz, Sheila Francis, Endre Kiss-Toth, Marc van Zandvoort, Andreas Schober, Paul Hellewell, Paul C. Evans, Victoria Ridger
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The role of neutrophils in the development of atherosclerosis has long been an enigma, with few neutrophils detected within the plaque. Here, the authors show that microvesicles released from neutrophils increase vascular inflammation and enhance ath
Externí odkaz:
https://doaj.org/article/56d869ba2dc54e5c8b181fd48b5df87b
Autor:
Amanda Burnett, Ingrid Gomez, David Davila De Leon, Mark Ariaans, Pavlos Progias, Richard A. Kammerer, Guillermo Velasco, Marie Marron, Paul Hellewell, Victoria Ridger
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
Abstract Angiopoietins are a family of growth factors that are ligands for the tyrosine kinase receptor, Tie2. Angiopoietin 1 (Ang-1) is agonistic for Tie2, plays a key role in blood vessel maturation and stability and has been shown to possess anti-
Externí odkaz:
https://doaj.org/article/13276e96cb424136925e3edbd894f7ad
Autor:
Victoria Ridger, Chiara Recarti, Marwa Mahmoud, Andreas Schober, Amanda Burnett, Merete Long, Ingrid Gomez, Ben Ward, Jessica Johnston, Marc A. M. J. van Zandvoort, Sheila E. Francis, Siôn A Parry, Paul G. Hellewell, Endre Kiss-Toth, Mark P. Ariaans, Celine Souilhol, Le Anh Luong, Rohit Bazaz, Laura West, Rachel M Woods, Birke J. Benedikter, Chiara Niespolo, Paul C. Evans, Carl J. Hulston
Publikováno v:
Nature Communications
Nature Communications, 11(1):214. Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Nature Communications, 11(1):214. Nature Publishing Group
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
Neutrophils are implicated in the pathogenesis of atherosclerosis but are seldom detected in atherosclerotic plaques. We investigated whether neutrophil-derived microvesicles may influence arterial pathophysiology. Here we report that levels of circu
Autor:
Chiara Recarti, Le Anh Luong, Amanda Burnett, Celine Souilhol, Ben Ward, Endre Kiss-Toth, Jessica Johnston, Victoria Ridger, Merete Long, Marwa Mahmoud, Sheila E. Francis, Andreas Schober, Siôn A Parry, Paul Hellewell, Marc A. M. J. van Zandvoort, Mark P. Ariaans, Carl J. Hulston, Birke J. Benedikter, Ingrid Gomez, Rachel M Woods, Laura West, Paul C. Evans, Rohit Bazaz
Neutrophils have been implicated in the pathogenesis of atherosclerosis, a lipid-driven disease of arteries, but they are seldom found in atherosclerotic plaques. To resolve this longstanding paradox, we investigated whether neutrophil-derived microv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809f542794cdfee829847af7dcd9abb4
Autor:
Amanda Burnett, Victoria Ridger, Marc Daigneault, Janet Chamberlain, Mabruka Alfaidi, Sheila E. Francis, Heather L. Wilson
Publikováno v:
Journal of Biological Chemistry. 290:24067-24078
The endothelium is critically involved in the pathogenesis of atherosclerosis by producing proinflammatory mediators, including interleukin-1 beta (IL-1β). Coronary arteries from patients with ischaemic heart disease express large amounts of IL-1β
Publikováno v:
Occupational therapy in health care. 27(4)
This study explored the construct validity of the Functional Simulated Technology Task (FSTT), online bill-pay version. The FSTT was administered to matched groups: persons with cognitive impairment and persons with no known cognitive impairment, est
Autor:
Victoria Ridger, Amanda Burnett, Sheila E. Francis, Janet Chamberlain, Mabruka Alfaidi, B H Abdul-Aema, Heather L. Wilson
Publikováno v:
Heart. 100:A2.2-A2
Introduction Atherosclerosis is characterized by endothelial dysfunction, massive inflammatory cell recruitment and activation of leukocytes, accompanied by extracellular release of interleukin-1 beta (IL-1β), a potent pro-inflammatory mediator with
Autor:
Victoria Ridger, Adrienn Angyal, Marc Daigneault, Heather L. Wilson, Amanda Burnett, Markus Ariaans, Endre Kiss-Toth, Eva Hadadi
Publikováno v:
Heart. 99:A126.1-A126
Introduction Mitogen activated protein kinase (MAPK) cascades are involved in the regulation of several cellular responses including migration or proliferation. We have shown previously that tribbles-1 (trb-1), a member of the tribbles family of adap
200 NEUTROPHIL-DERIVED MICROPARTICLES MODULATE MONOCYTE MIGRATION IN AN ENDOTHELIAL DEPENDENT MANNER
Publikováno v:
Heart. 99:A110.3-A111
Introduction Neutrophil depletion can delay atherogenesis and conversely increasing circulating neutrophils enhances plaque progression in mice. Lack of evidence for the presence of neutrophils in atherosclerotic plaques makes their role in disease p
Publikováno v:
Heart. 98:A3.3-A4
Rationale Monocytes play a major role in atherosclerosis progression through migration into the arterial wall. Neutrophil involvement in atherosclerosis was previously only thought to be via enzymatic weakening of the fibrous cap. However, neutrophil